中国组织工程研究 ›› 2017, Vol. 21 ›› Issue (17): 2776-2782.doi: 10.3969/j.issn.2095-4344.2017.17.024

• 干细胞综述 stem cell review • 上一篇    下一篇

间充质干细胞免疫调控功能及临床应用

杨燕美1,江小霞2,温  宁1   

  1. 1解放军总医院口腔科,北京市  100853;2解放军军事医学科学院基础医学研究所,北京市  100850
  • 修回日期:2017-05-02 出版日期:2017-06-18 发布日期:2017-06-29
  • 通讯作者: 温宁,主任医师,教授,解放军总医院口腔科,北京市 100853
  • 作者简介:杨燕美,女,江苏省溧阳市人,汉族,解放军总医院口腔科在读博士,主要从事间充质干细胞的免疫调控研究。
  • 基金资助:

    国家863计划(2013AA032201);北京市自然科学基金资助项目(7162142);国家自然科学基金(81271936)

The immunomodulatory function and clinical applications of mesenchymal stem cells

Yang Yan-mei1, Jiang Xiao-xia2, Wen Ning1   

  1. 1Department of Stomatology, Chinese PLA General Hospital, Beijing 100853, China; 2Department of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China
  • Revised:2017-05-02 Online:2017-06-18 Published:2017-06-29
  • Contact: Wen Ning, Chief physician, Professor, Department of Stomatology, Chinese PLA General Hospital, Beijing 100853, China
  • About author:Yang Yan-mei, Studying for doctorate, Department of Stomatology, Chinese PLA General Hospital, Beijing 100853, China
  • Supported by:

    the National Hight-Technology Research and Development Project of China (“863” Program), No. 2013AA032201; the Natural Science Foundation of Beijing, No. 7162142; the National Natural Science Foundation of China, No. 81271936

摘要:

文章快速阅读:

文题释义:
Blimp-1:
全称叫B淋巴细胞诱导成熟蛋白1,是具有5个锌指结构的蛋白,是一种转录抑制因子。在B细胞系,Blimp-1主要表达于浆细胞和成熟B细胞阶段,是B细胞终末分化的主调控因子,促进B细胞分化为浆细胞并产生抗体,同时对浆细胞存活也起着重要作用。
Toll样受体:是天然免疫细胞主要的模式识别受体,主要识别病原微生物。Toll样受体是一个大家族,已发现10种人类Toll样受体和12种鼠类Toll样受体,均为Ⅰ型跨膜受体。Toll样受体不仅存在于各种免疫细胞表面,更是在间充质干细胞表面表达,而且对间充质干细胞的增殖、分化、迁移以及免疫调节能力都有着重要的调控作用。

 

摘要
背景:
间充质干细胞具有自我更新、多向分化以及免疫调节能力,已经成为当前研究的热点。
目的:总结间充质干细胞对多种免疫细胞的调控作用以及在临床免疫相关疾病治疗中的应用。
方法:以“mesenchymal stem cells,immunomodulation,MSC1 and MSC2,autoimmune diseases,间充质干细胞,免疫调节,自身免疫病”为检索词,由第一作者检索PubMed数据库和CKNI数据库1974年1月至2016年12月相关文献。最终选取52篇代表文献。
结果与结论:间充质干细胞能够抑制T淋巴细胞功能、降低B细胞的活化增殖及抗体分泌、影响巨噬细胞极化、抑制树突状细胞的成熟、抑制NK细胞的增殖和毒性,故其具有治疗免疫相关疾病的巨大潜力。但是间充质干细胞在不同炎症微环境作用下能够表现出截然相反的免疫调节能力,并且关于这一现象明确又可控的机制仍不完全清楚,所以间充质干细胞在临床免疫相关疾病中发挥作用的具体机制是未来的研究方向。

 

 

ORCID: 0000-0002-2792-9990(杨燕美)

关键词: 干细胞, 移植, 免疫调控, 间充质干细胞的极化, 免疫相关疾病, 国家自然科学基金

Abstract:

BACKGROUND: Mesenchymal stem cells (MSCs) have the abilities of self-renewal, multidirectional differentiation and immunomodulation, and have become the focus of current research.
OBJECTIVE: To summarize the immunomodulation of MSCs to different immune cells and the clinical applications of MSCs in the treatment of immune-related diseases.
METHODS: The first author searched the PubMed and the CKNI databases for relative articles from January 1974 to December 2016. The key words were “mesenchymal stem cells, immunomodulation, MSC1 and MSC2, autoimmune diseases” in English and Chinese, respectively. Finally, 52 representative articles were included.
RESULTS AND CONCLUSION: MSCs can inhibit the function of T lymphocytes, reduce the activation, proliferation and antibody secretion of B lymphocytes, affect the polarization of macrophages, inhibit the maturation of dendritic cells, inhibit the proliferation and toxicity of NK cells, so MSCs have the great potential in the treatment of immune-related diseases. However, MSCs exhibit the opposite immunomodulatory abilities under different inflammatory microenvironments, and moreover the definite and controllable mechanism of this phenomenon is still unclear, Therefore, future investigations may focus on the specific mechanism of MSCs in the clinical treatment of immune-related diseases.

 

 

Key words: Mesenchymal Stem Cells, Immunomodulation, Autoimmune Diseases, Tissue Engineering

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