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文题释义：
天然神经导管材料：具有生物相容性好、毒副作用少的优点，并且有利于许旺细胞移动。其主要缺点在于，这些材料虽然具有与机体极好的生物相容性，但是这些生物活性材料在缺血后存在管型塌陷、再生不良、吸收瘢痕组织增生及粘连、无法预计的免疫反应、免疫抑制以及制作工艺的繁琐性。当用于临床前，这类天然材料需要储存相当长的时间，一般而言，天然材料在51 ℃储存3周后，可保持与新鲜时近似的桥接功能，但随着保存时间和温度的变化，其内部的降解将影响功能，典型的天然材料包括静脉管、肌膜。
神经导管内支架：神经导管内支架是指在传统的神经导管的基础上，对导管内部结构所作的进一步创新，如内表面微沟槽化处理，引入内部置入物，多层管中管结构，多管道结构等，旨在模拟正常神经生长的微环境，更加精细有效地支持引导和促进神经的再生，使再生的神经从形态特点和结构功能上更加接近于正常的神经组织。
摘要
背景：在周围神经修复方面，神经导管已由传统的无内支架结构逐步走向内部结构的创新，以构建更加有利于周围神经再生的具有内支架结构的神经导管。因此对于神经导管内部支架结构的全面了解是十分必要的。
目的：综述近年来神经导管内支架在修复周围神经缺损方面的应用。
方法：以“nerve conduit/conduits/scaffolds/scaffold/channel/channels，internal scaffolds /scaffold，nerve regeneration/repair，hydrogel，acellularized/ decellularized nerve”或“神经导管，内支架，周围神经修复，凝胶，去细胞神经”为检索词，应用计算机分别在PubMed 数据库和中国知网、万方数据库、中国生物医学文献数据库，检索 2009年1月至 2015年12月与神经导管内支架相关的文章，对纳入的47篇符合标准的文献进行综述。
结果与结论：具有内支架结构的神经导管相较于传统的无内支架结构的神经导管在修复周围神经缺损方面有明显优势，可以更加有效的支持、引导和促进周围神经的再生与功能的恢复，有些神经导管内支架复合种子细胞、神经营养因子、细胞外基质后修复效果更佳，甚至与自体神经移植具有相似的修复效果。
中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程
ORCID: 0000-0002-8469-2328(陈军)
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文题释义：
天然神经导管材料：具有生物相容性好、毒副作用少的优点，并且有利于许旺细胞移动。其主要缺点在于，这些材料虽然具有与机体极好的生物相容性，但是这些生物活性材料在缺血后存在管型塌陷、再生不良、吸收瘢痕组织增生及粘连、无法预计的免疫反应、免疫抑制以及制作工艺的繁琐性。当用于临床前，这类天然材料需要储存相当长的时间，一般而言，天然材料在51 ℃储存3周后，可保持与新鲜时近似的桥接功能，但随着保存时间和温度的变化，其内部的降解将影响功能，典型的天然材料包括静脉管、肌膜。
神经导管内支架：神经导管内支架是指在传统的神经导管的基础上，对导管内部结构所作的进一步创新，如内表面微沟槽化处理，引入内部置入物，多层管中管结构，多管道结构等，旨在模拟正常神经生长的微环境，更加精细有效地支持引导和促进神经的再生，使再生的神经从形态特点和结构功能上更加接近于正常的神经组织。