中国组织工程研究 ›› 2017, Vol. 21 ›› Issue (4): 586-590.doi: 10.3969/j.issn.2095-4344.2017.04.016

• 脊柱组织构建 spinal tissue construction • 上一篇    下一篇

骨质疏松对种植义齿修复及预后的影响

单健良,张  琴,胡  杨,姚  源,张  玮,何惠宇   

  1. 新疆医科大学第一附属医院口腔修复科,新疆维吾尔自治区乌鲁木齐市  830054
  • 收稿日期:2016-11-21 出版日期:2017-02-08 发布日期:2017-03-13
  • 通讯作者: 通讯作者:何惠宇,博士, 主任医师,新疆医科大学第一附属医院口腔修复科,新疆维吾尔自治区乌鲁木齐市 830054
  • 作者简介:单健良,男,1989年生,山东省人,新疆医科大学在读硕士研究生,主要从事口腔修复与种植研究。
  • 基金资助:

    乌鲁木齐市科技局项目(Y151310006)

Effect of osteoporosis on the prognosis of implant dentures

Shan Jian-liang, Zhang Qin, Hu Yang, Yao Yuan, Zhang Wei, He Hui-yu   

  1. Department of Prosthodontics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
  • Received:2016-11-21 Online:2017-02-08 Published:2017-03-13
  • Contact: Corresponding author: He Hui-yu, M.D., Chief physician, Department of Prosthodontics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
  • About author:Shan Jian-liang, Studying for master’s degree, Department of Prosthodontics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
  • Supported by:

    the Project of Urumqi Science & Technology Bureau, No. Y151310006

摘要:

 

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文题释义:

骨质疏松:是一种因骨量减少、骨骼微细结构发生破坏,导致骨骼脆弱而易发生骨折的骨骼系统疾病。骨质疏松的发生与诸多因素相关,其中雌激素水平变化、营养、遗传、生活方式等最为密切。骨质疏松可分为原发性和继发性两类。原发性骨质疏松系指不伴引起本病的其他疾患;继发性骨质疏松则是由于各种全身性或内分泌代谢性疾病引起的骨组织量减少,颌骨可成为骨质疏松的主要发生部位,引起颌骨骨量降低,从而影响种植。
种植义齿:是在口腔缺牙区的牙槽骨内植入种植体(人工牙根),待种植体成活后,再在其上端制作修复体完成种植义齿的修复。它能显著地提高患者的咀嚼功能,且具有良好的美学效果,利用锥形束CT检查种植区骨质骨量,动度测量仪检测种植体稳定性,以及后期的随访观察都可以为种植义齿的远期修复提供临床依据。

摘要
背景:
种植义齿由于具有良好的功能和美观效果,因此越来越多患有骨质疏松症的缺牙患者要求接受种植义齿治疗,而目前对骨质疏松是否是种植义齿的禁忌证、骨质疏松对种植体骨性结合形成有怎样的影响作用等问题没有统一的认识。
目的:比较骨质疏松患者和非骨质疏松患者碱性磷酸酶水平、骨密度变化以及种植体稳定性,探究骨质疏松患者能否取得良好的种植预后。
方法:选自2015年2月以来在新疆医科大学第一附属医院口腔修复科行种植手术的患者40例,按是否确诊为骨质疏松分为试验组和对照组。其中试验组为骨质疏松且行种植义齿修复的患者20例,对照组为非骨质疏松且行种植义齿修复患者20例。
结果与结论:2组患者唾液碱性磷酸酶水平、骨密度、种植体初期稳定性接近,种植后均较种植前碱性磷酸酶表达降低。试验组和对照组在种植后1,3个月种植体稳定系数与植入后即刻差异有显著性意义。说明骨质疏松患者行种植手术和正常健康者一样,可以达到良好的种植预后效果。

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程
ORCID:0000-0003-1918-579X(何惠宇)

关键词: 组织构建, 骨组织工程, 骨质疏松, 种植义齿, 碱性磷酸酶, 骨密度, 种植体稳定性, 动度测量仪, 非刺激性全唾液, 锥形束CT

Abstract:

Abstract
BACKGROUND
: Due to good function and aesthetic effect, implant dentures become prevalent in osteoporotic patients with missing teeth. However, whether osteoporosis is a contraindication of dentures as well as effects of osteoporosis on the bone-implant integration have been not fully understood.
OBJECTIVE: To compare the levels of alkaline phosphatase, bone mineral density and implant stability in patients with osteoporosis and non-osteoporosis, and to explore whether the osteoporotic patients can achieve good prognosis.
METHODS: Forty patients undergoing implant dentures in the Department of Prosthodontics, the First Affiliated Hospital of Xinjiang Medical University since February 2015 were enrolled, and allotted to experimental (osteoporosis) and control (non-osteoporosis) groups (n=20 per group).
RESULTS AND CONCLUSION: The levels of salivary alkaline phosphatase, bone mineral density and initial implant stability in the experiment and control groups both were lower than those before surgery. There were significant differences in the implant stability quotient at 1 and 3 months and immediately after implantation between groups. These results indicate that osteoporotic patients undergoing implant surgery can achieve a good prognosis that is similar with non-osteoporosis ones.

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程

Key words: Bone Density, Osteoporosis, Dentures, Tissue Engineering

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