中国组织工程研究

中国组织工程研究 ›› 2016, Vol. 20 ›› Issue (52): 7821-7828.doi: 10.3969/j.issn.2095-4344.2016.52.010

• 生物材料综述 biomaterial review • 上一篇    下一篇

3D打印钛合金孔隙支架骨长入影响因素的分析

王中汉，王辰宇，刘  贺，李  忱，秦彦国，蔡晓宇，王金成
  

  1. 吉林大学第二医院，吉林省长春市 130041
  • 收稿日期:2016-09-21 出版日期:2016-12-16 发布日期:2016-12-16
  • 通讯作者: 王金成，主任医师，教授，博士生导师，吉林大学第二医院，吉林省长春市 130041
  • 作者简介:王中汉，男，1992 年生，汉族，吉林大学第二医院在读硕士，主要从事3D打印金属支架在骨科方面应用的研究。
  • 基金资助:

    吉林省科技厅国际合作处基金(20150414006GH)；吉林省科技厅专利管理处基金(20150312028ZG)；吉林省科技厅高新处基金(20130206060GX)；吉林大学白求恩医学部博士研究生拔尖人才培育计划(YB201501)；吉林大学研究生创新基金支持(2016108、2016041)

Effects of three-dimensional printed porous titanium scaffolds on bone ingrowth

Wang Zhong-han, Wang Chen-yu, Liu He, Li Chen, Qin Yan-guo, Cai Xiao-yu, Wang Jin-cheng
  

  1. the Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
  • Received:2016-09-21 Online:2016-12-16 Published:2016-12-16
  • Contact: Wang Jin-cheng, Chief physician, Professor, Doctoral supervisor, the Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
  • About author:Wang Zhong-han, Studying for master’s degree, the Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
  • Supported by:
    the International Cooperation Department Foundation of Jilin Provincial Science and Technology Department, No. 20150414006GH; the Patent Management Department Foundation of Jilin Provincial Science and Technology Department, No. 20150312028ZG; the High-Tech Department Foundation of Jilin Provincial Science and Technology Department, No. 20130206060GX; the Talent Training Program for the Doctoral and Postgraduate of Norman Bethune Health Science Center of Jilin University, No. YB201501; the Postgraduate Innovation Foundation of Jilin University, No. 2016108, 2016041

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摘要：

文章快速阅读：

 

文题释义：
金属3D打印：是将数字模式文件作为模板制造物品的一种快速成型技术。在制造过程中，多种固化技术，如电子束熔融和激光束熔融被用以将金属材料粉末逐层融化后，根据预先的数据设置塑造成不同的形状。相比于传统制造工艺，3D打印的特点在于其自由的定制化和基于数字模板的铸造过程。
3D打印的优点：可制造出有着联通孔隙的生物材料。孔隙率、孔隙尺寸及形状也为预先设定的规律形状，而非传统技术制造的不规则尺寸及形状。植入物的压缩强度和弹性模量受到孔隙率的影响，故而植入物的机械性能也可以通过3D打印技术调整孔隙率来达到与人体骨骼相匹配，使得植入物的应力遮挡效应得以避免。

背景：随着3D打印技术的发展，3D打印孔隙钛合金支架作为骨替代物成为当今研究的热点。
目的：介绍并讨论3D打印孔隙钛合金支架各项参数对骨长入效果的影响，总结出最适于骨长入支架的参数特点。
方法：作者以“Three-dimensional(3D)printing，Scaffold，Titanium，Bone ingrowth”为关键词，检索2006至2016年期间PubMed、Springerlink、Medline数据库中相关文献。初检文章125篇，筛选后对42篇文章进行分析。
结果与结论：3D打印钛合金支架的孔隙尺寸、孔隙率、孔隙形状和表面处理方式等参数，对于骨长入效果或体外支架内成骨细胞表现都有着重要的影响。合适的孔隙尺寸和孔隙率对于支架内组织的氧供和血管生成有着促进作用；孔隙形状和表面处理方式则主要对于支架内成骨细胞有着调控作用，影响细胞的黏附、增殖、分化等行为。综合最适于骨长入几项参数，通过3D打印技术可制造最适宜的支架，以达到最佳的骨长入效果，获得高强度的骨-支架界面的稳定性。

关键词: 生物材料, 骨生物材料, 植入物, 孔隙尺寸, 孔隙率, 形状, 表面处理, 稳定性, 负重区

Abstract:

BACKGROUND: With the development of three-dimensional (3D) printing technology, 3D printed porous titanium scaffolds as bone substitutes have become a research hotspot.
OBJECTIVE: To introduce and discuss the effects of each parameter of 3D printed porous titanium scaffolds on bone ingrowth, and to sum out the optimal parameters for bone ingrowth.
METHODS: The first author retrieved PubMed, Springerlink and Medline databases with “three-dimensional (3D) printing, scaffold, titanium, bone ingrowth” as keywords for relevant articles published from 2006 to 2016. 125 articles were retrieved initially, and finally 42 eligible articles were included for analysis.
RESULTS AND CONCLUSION: Pore size, porosity, pore structures and surface modifications of 3D printed porous titanium scaffolds all make effects on bone ingrowth or osteoblasts in scaffolds. Scaffolds with appropriate pore size and porosity can promote the vascularization and provide adequate nutrition and oxygen supplement, to ensure high cell viability. Regulations of cell performances, such as cell attachment, proliferation and differentiation, are also affected by pore structures and nano-scale surface modification. Herein, a detailed combination of the parameters, as mentioned above, can create a better porous scaffold for better bone ingrowth. Hence, the high-stability interface between bone and scaffolds may be obtained through the parameter adjustment.

Key words: Titanium, Alloys, Tissue Engineering

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