中国组织工程研究

中国组织工程研究 ›› 2016, Vol. 20 ›› Issue (46): 6963-6969.doi: 10.3969/j.issn.2095-4344.2016.46.017

• 组织构建综述 tissue construction review • 上一篇    下一篇

成骨细胞、破骨细胞与酒精性股骨头坏死的关联性：
预防与靶向治疗的新思路

陈俊宇1，2，王建忠1，2   

  1. 1内蒙古医科大学，内蒙古自治区呼和浩特市   010030；2内蒙古医科大学第二附属医院创伤1科，内蒙古自治区呼和浩特市  010030
  • 收稿日期:2016-09-04 出版日期:2016-11-11 发布日期:2016-11-11
  • 通讯作者: 王建忠，博士，主任医师，内蒙古医科大学，内蒙古自治区呼和浩特市 010030；内蒙古医科大学第二附属医院创伤Ⅰ科，内蒙古自治区呼和浩特市 010030
  • 作者简介:陈俊宇，男，1990年生，辽宁省营口市人，汉族，内蒙古医科大学在读硕士，主要从事股骨头坏死相关研究。
  • 基金资助:

    国家自然科学基金(81160228)，课题名：OPG/RANKL/RANK基因多态性与蒙汉两族人群激素性骨坏死和酒精性骨坏死的关联性及淫羊藿提取物个体化防治研究

Correlation of osteoblasts and osteoclasts with alcohol-induced femoral head necrosis: a new strategy of prevention and target therapy

Chen Jun-yu1, 2, Wang Jian-zhong1, 2   

  1. 1Inner Mongolia Medical University, Hohhot 010030, Inner Mongolia Autonomous Region, China; 2First Department of Traumatology, the Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, Inner Mongolia Autonomous Region, China
  • Received:2016-09-04 Online:2016-11-11 Published:2016-11-11
  • Contact: Wang Jian-zhong, M.D., Chief physician, Inner Mongolia Medical University, Hohhot 010030, Inner Mongolia Autonomous Region, China; First Department of Traumatology, the Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, Inner Mongolia Autonomous Region, China
  • About author:Chen Jun-yu, Studying for master’s degree, Inner Mongolia Medical University, Hohhot 010030, Inner Mongolia Autonomous Region, China; First Department of Traumatology, the Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, Inner Mongolia Autonomous Region, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81160228

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摘要：

文章快速阅读：

文题释义：
成骨细胞：是骨形成的主要功能细胞，负责骨基质的合成、分泌和矿化。骨不断地进行着重建，骨重建过程包括破骨细胞贴附在旧骨区域，分泌酸性物质溶解矿物质，分泌蛋白酶消化骨基质，形成骨吸收陷窝；其后，成骨细胞移行至被吸收部位，分泌骨基质，骨基质矿化而形成新骨。破骨与成骨过程的平衡是维持正常骨量的关键。
破骨细胞：是骨细胞的一种，行使骨吸收的功能。破骨细胞与成骨细胞在功能上相对应。二者协同，在骨骼的发育和形成过程中发挥重要作用。高表达的抗酒石酸酸性磷酸酶和组织蛋白酶K是破骨细胞主要标志。

摘要
背景：酒精性股骨头坏死的病理过程主要是酒精中毒引起的骨细胞脂肪变性、坏死、沉积及骨髓间充质干细胞分化成骨细胞、破骨细胞过程异常导致的骨代谢紊乱引起骨质疏松，进而造成股骨头软骨下骨小梁塌陷，最终导致股骨头缺血性坏死。
目的：就成骨细胞、破骨细胞与酒精性股骨头坏死的关联性做系统性综述。
方法：第一作者应用计算机检索2016年5月前PubMed数据库、中国期刊全文数据库的相关文章，英文检索词“osteoblast，osteoclast，alcohol-induced ONFH，bone metabolism”；中文检索词“成骨细胞，破骨细胞，酒精性股骨头坏死，骨代谢”。共检索到133篇相关文献，38篇文献符合纳入标准。
结果与结论：在骨代谢过程中，成骨细胞的数量与活性影响、调控破骨细胞的数量与活性，而破骨细胞的数量与活性也会反作用于成骨细胞。不断深入了解探索成骨细胞、破骨细胞及其之间的作用机制，不仅能够对酒精性股骨头坏死的发病及修复机制有更为详尽的认识，更能够对其他相关骨代谢疾病的预防与靶向治疗提供新的思路与策略。

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程
ORCID: 0000-0002-5245-8406(陈俊宇)

关键词: 组织构建, 骨组织工程, 成骨细胞, 破骨细胞, 酒精性股骨头坏死, 骨代谢, 国家自然科学基金

Abstract:

BACKGROUND: Alcohol-induced femoral head necrosis is a bone metabolism disease that involves a series of alcoholism-induced pathological changes, including degeneration, necrosis and deposition of adipocytes and osteoporosis, and trabecular collapse in the subchondral bone trabeculae of the femoral head.
OBJECTIVE: To introduce the correlation of osteoblasts and osteoclasts with alcohol-induced femoral head necrosis.
METHODS: The first author searched relative articles in PubMed and CNKI databases published before May 2016 using the keywords of “osteoblast, osteoclast, alcohol-induced ONFH, bone metabolism” in English and Chinese, respectively. 133 literatures were retrieved and 38 literatures were in accordance with the inclusion criteria.
RESULTS AND CONCLUSION: During the process of bone metabolism, osteoblasts and osteoclasts exhibit interaction in term of cell number and viability. In-depth study on osteoblasts, osteoclasts and their interaction cannot only give insight into the pathogenesis and repair of alcohol-induced femoral head necrosis, but also provide new ideas and strategies for prevention and target treatment of bone metabolic diseases.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Osteoblasts, Osteoclasts, Femur Head Necrosis, Metabolism, Tissue Engineering

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