中国组织工程研究

中国组织工程研究 ›› 2016, Vol. 20 ›› Issue (3): 430-434.doi: 10.3969/j.issn.2095-4344.2016.03.023

• 生物材料综述 biomaterial review • 上一篇    下一篇

智能水凝胶在骨类硬组织再生和修复中的应用

杨 琳1，管晓燕1，2，陈黎明3，刘建国1，2   

  1. 1遵义医学院口腔学院，贵州省遵义市  563099；2贵州省高等学校口腔疾病研究特色重点实验室，遵义市口腔疾病研究重点实验室，贵州省遵义市 563099；3贵阳市口腔医院，贵州省贵阳市  550002
  • 出版日期:2016-01-15 发布日期:2016-01-15
  • 通讯作者: 刘建国，教授，博士 ，遵义医学院口腔学院，贵州省遵义市 563099
  • 作者简介:杨琳，女，1989年生，辽宁省铁岭市人，汉族，硕士，主要从事龋病的病因与防治研究。
  • 基金资助:
    贵州省科技创新人才团队建设项目(黔科合人才团队[2013]4026)；贵州省高等学校重点学科建设项目(SZXK-201207-04号)；贵州省高等学校特色重点实验室建设项目(黔教合KY字[2013]109)；贵州省科技厅联合基金项目(黔科合SY字合J字[2012]47号)和省市科技合作专项资金项目(省市科合[2014]41号)

Application of intelligent hydrogels in bone regeneration and repair

Yang Ling1, Guan Xiao-yan1, 2, Chen Li-ming3, Liu Jian-guo1, 2   

  1. 1School of Stomatology, Zunyi Medical University, Zunyi 563099, Guizhou Province, China; 2the Special Key Laboratory of Oral Diseases Research, Institution of Higher Education in Guizhou Province, the Key Laboratory of Oral Diseases Research of Zunyi City, Zunyi 563099, Guizhou Province, China; 3Guiyang Stomatological Hospital, Guiyang 550002, Guizhou Province, China
  • Online:2016-01-15 Published:2016-01-15
  • Contact: Liu Jian-guo, M.D., Professor, School of Stomatology, Zunyi Medical University, Zunyi 563099, Guizhou Province, China; the Special Key Laboratory of Oral Diseases Research, Institution of Higher Education in Guizhou Province, the Key Laboratory of Oral Diseases Research of Zunyi City, Zunyi 563099, Guizhou Province, China
  • About author:Yang Lin, Master, School of Stomatology, Zunyi Medical University, Zunyi 563099, Guizhou Province, China
  • Supported by:
    the Scientific Innovation Talent Team Fund of Guizhou Province, No. [2013]4026;   the Key Discipline Construction Project of Higher Education in Guizhou Province, No. SZXK-201207-04; the Special Key Laboratory Building Project of Higher Education in Guizhou Province, No. KY[2013]109; Joint Fund of Science and Technology Department of Guizhou Province, No. SY-J[2012]47; Scientific Cooperation Project of Guizhou Province and Zunyi City, No. [2014]41

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被引次数

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摘要：

文章快速阅读：

文题释义：

水凝胶：是以水作为分散介质的凝胶，是一部分疏水基团被引入到具有交联结构的水溶性高分子中，形成能够遇水膨胀的交联聚合物，是一种高分子三维网络体系，能保持一定的形状，性质柔软，可吸收大量的水，但又不会溶解。
智能水凝胶：能感知外界刺激的微小变化，并对某些特异的刺激发生敏感性响应。基于该特性，智能水凝胶在生物医药、组织工程、记忆元件开关、生物酶的固定等相关领域得到了广泛应用，在医学研究领域、伤口敷裹、药物释放载体、人造器官等方面已成为近年来的研究热点。

 

背景：智能水凝胶作为一种新兴材料被广泛应用于生物医药、组织工程、记忆元件开关、生物酶固定等相关领域，并表现出较好的生物特性，为智能水凝胶运用于骨等硬组织的再生和修复提供了新的思路。

目的：综述智能水凝胶在生物医药和组织工程等相关领域研究的最新进展，寻找骨等硬组织再生和修复的新方法。
方法：应用计算机检索中国知网、PubMed及EBSCO-MEDLINE数据库从2000至2015年有关组织工程中智能水凝胶关于在骨及骨类硬组织再生、骨修复中应用的文献，英文检索词有“hydrogel，bone tissue engineering，bone defect，regeneration，repair”，中文检索词有“水凝胶，组织工程，骨再生，骨修复”。

结果与结论：智能水凝胶中包括pH敏感型、温度敏感型、光敏感型、多重敏感型及其他敏感型水凝胶。为提高水凝胶的矿化能力、构建水凝胶三维聚合物支架，可在水凝胶材料主体结构上复合各种信号因子，进而实现材料体系的多效用、多功能，将成为构建组织工程材料的发展趋势。 

 

ORCID: 0000-0001-7968-0659(刘建国)

关键词: 生物材料, 骨生物材料, 水凝胶, 分类, 矿化能力, 骨再生, 骨修复, 支架, 应用

Abstract:

BACKGROUND: Intelligent hydrogel as a new material is widely used in biological medicine, tissue engineering, memory element switch, biological enzyme immobilization and other related fields, and exhibits good biological characteristics. Intelligent hydrogels provide a new approach for regeneration and repair of bone and other hard tissues. 
OBJECTIVE: To summarize the latest developments of intelligent hydrogel in the biological medicine and tissue engineering in order to find out new methods for regeneration and repair of bone and other hard tissues.
METHODS: A computer-based research of CNKI, PubMed and EBSCO-MEDLINE databases was performed to retrieve relevant literatures about the application of intelligent hydrogel in regeneration and repair of bone and other hard tissues published from 2000 to 2015. The keywords were “hydrogel, bone tissue engineering, bone defect, regeneration, repair” in Chinese and English, respectively.
RESULTS AND CONCLUSION: Intelligent hydrogels are classified into pH-sensitive, temperature-sensitive, light-sensitive, multiple-sensitive and other sensitive hydrogels. In order to improve the mineralization ability of the hydrogel and construct the three-dimensional polymer scaffold of hydrogel, the main structure of the hydrogel materials can be mixed with various signal factors, thus achieving the multi-utility and multi-function of the material system, which will become the development trend of tissue engineering construction.