中国组织工程研究

中国组织工程研究 ›› 2015, Vol. 19 ›› Issue (42): 6740-6745.doi: 10.3969/j.issn.2095-4344.2015.42.004

• 口腔组织构建 oral tissue construction • 上一篇    下一篇

失下牙槽神经支配与拔牙窝新骨形成及骨量保持

王承勇1，2，陈伟辉1，2，卢 萌1，2，王 锦1，2，茅传青1，2，林 海3   

  1. 1福建医科大学牙颌面畸形防治研究室，福建省福州市 350001； 2福建医科大学附属协和医院口腔颌面外科，福建省福州市 350001；3厦门市口腔医院种植科，福建省厦门市 361000
  • 出版日期:2015-10-08 发布日期:2015-10-08
  • 通讯作者: 陈伟辉，博士，硕士生导师，副教授，福建医科大学附属协和医院口腔颌面外科，福建省福州市 350001
  • 作者简介:王承勇，男，1980年生，汉族，福建省福清市人，2003年福建医科大学毕业，硕士，主治医师。
  • 基金资助:

    国家自然科学基金(31070838)；福建省自然科学基金杰出青年项目(2012J06017)；福建省卫生厅青年基金(2012-1-20)

     

Denervation of the inferior alveolar nerve is associated with bone formation and bone mass maintenance in extraction sockets

Wang Cheng-yong1, 2, Chen Wei-hui1, 2, Lu Meng1, 2, Wang Jin1, 2, Mao Chuan-qing1, 2, Lin Hai3   

  1. 1Department of Maxillofacial Deformity Prevention, Fujian Medical University, Fuzhou 350001, Fujian Province, China; 2Department of Oral and Maxillofacial Surgery, Union Hospital, Fujian Medical University, Fuzhou 350001, Fujian Province, China; 3Department of Dental Implantation, Xiamen Stomatological Hospital, Xiamen 361000, Fujian Province, China
  • Online:2015-10-08 Published:2015-10-08
  • Contact: Chen Wei-hui, M.D., Master’s supervisor, Associate professor, Department of Maxillofacial Deformity Prevention, Fujian Medical University, Fuzhou 350001, Fujian Province, China; Department of Oral and Maxillofacial Surgery, Union Hospital, Fujian Medical University, Fuzhou 350001, Fujian Province, China
  • About author:Wang Cheng-yong, Master, Attending physician, Department of Maxillofacial Deformity Prevention, Fujian Medical University, Fuzhou 350001, Fujian Province, China; Department of Oral and Maxillofacial Surgery, Union Hospital, Fujian Medical University, Fuzhou 350001, Fujian Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 31070838; the Natural Science Foundation of Fujian Province, No. 2012J06017; the Youth Fund of Fujian Provincial Health Department, No. 2012-1-20

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摘要：

背景：牙齿拔除后拔牙窝内新骨形成及改建与神经支配密切相关。
目的：探讨失神经支配对拔牙窝新骨形成和骨量保持的可能调节作用。
方法：切除犬一侧下牙槽神经建立失神经支配动物模型，失神经支配侧为实验组，以未切除侧为对照组，组织学染色检测术后2，4，8，12周时间点拔牙窝新骨形成和骨量保持。
结果与结论：实验组拔牙窝骨缺损区的新生骨量面积百分比在术后2，4，8周明显低于对照组(P < 0.01)；术后2，4，8，12周，实验组颊舌侧牙槽嵴高度差明显高于对照组(P < 0.05或P < 0.01)。说明失神经支配与拔牙窝新骨形成和骨量保持存在密切相关性。
中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

关键词: 组织构建, 骨组织工程, 神经支配, 失神经支配, 拔牙窝, 骨愈合, 骨量, 国家自然科学基金

Abstract:

BACKGROUND: There is a close relationship between innervations and bone formation and bone mass maintenance in the extraction sockets.

OBJECTIVE: To study the possible effect of denervations on the regulation of new bone formation and bone mass maintenance in the extraction sockets.
METHODS: The unilateral inferior nerve of dogs was sectioned to establish an animal denervation model. The normal side was used as control. After model establishment, the premolars of denervated side and normal side were extracted. Histological method was used to test new bone formation and bone mass maintenance in the extraction sockets at the 2nd, 4th, 8th and 12th weeks after tooth extraction.

RESULTS AND CONCLUSION: The percentage of new bone areas in the extraction sockets was significantly lower in the experiment group than the control group at weeks 2, 4, 8 after tooth extraction (P < 0.01). The height difference between the buccal and lingual alveolar ridge was higher in the experimental group than the control group at weeks 2, 4, 8, 12 after tooth extraction (P < 0.05 or P < 0.01). These findings indicate that denervation is closely related with new bone formation and bone mass maintenance in the extraction sockets.
中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Tissue Engineering, Mouth, Osteogenesis