中国组织工程研究

中国组织工程研究 ›› 2014, Vol. 18 ›› Issue (47): 7550-7555.doi: 10.3969/j.issn.2095-4344.2014.47.002

• 组织工程骨及软骨材料 tissue-engineered bone and cartilage materials • 上一篇    下一篇

新型α-半水硫酸钙/双相生物陶瓷人工骨修复兔桡骨骨缺损的X射线评估

姚  彪1，钱卫庆2，尹  宏2   

  1. 1南京中医药大学，江苏省南京市  210046
    2南京中医药大学第三附属医院骨科，江苏省南京市  210001
  • 修回日期:2014-10-23 出版日期:2014-11-19 发布日期:2014-11-19
  • 通讯作者: 尹宏，主任医师，硕士生导师，南京中医药大学第三附属医院骨科，江苏省南京市 210001
  • 作者简介:姚彪，男，1984年生，江苏省扬州市人，汉族，南京中医药大学在读硕士。
  • 基金资助:

    南京市医学科技发展基金项目(YKK11048)

X-ray evaluation of alpha-calcium sulfate hemiydrate/biphasic bioceramics bone for repairing bone defects of rabbit radius

Yao Biao1, Qian Wei-qing2, Yin Hong2   

  1. 1Nanjing University of Traditional Chinese Medicine, Nanjing 210046, Jiangsu Province, China
    2Department of Orthopedics, Third Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210001, Jiangsu Province, China
  • Revised:2014-10-23 Online:2014-11-19 Published:2014-11-19
  • Contact: Yin Hong, Chief physician, Master’s supervisor, Department of Orthopedics, Third Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210001, Jiangsu Province, China
  • About author:Yao Biao, Studying for master’s degree, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, Jiangsu Province, China
  • Supported by:

    the Medical Science and Technology Development Fund of Nanjing City, No. YKK11048

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摘要：

背景：α-半水硫酸钙和双相生物陶瓷作为骨修复材料已在临床广泛应用，但都存在一定的缺点。
目的：观察α-半水硫酸钙/双相生物陶瓷人工骨用于修复兔桡骨缺损的效果。
方法：建立18只成年新西兰大白兔任一单侧桡骨缺损模型，随机分为3组，分别于骨缺损处植入α-半水硫酸钙材料、α-半水硫酸钙/双相生物陶瓷材料与双相生物陶瓷材料，植入后第4，8，12周时取材，对3组进行大体观察及X射线观察。
结果与结论：①大体观察：植入第12周，α-半水硫酸钙/双相生物陶瓷组骨缺损空腔完全修复，桡骨形状基本恢复到术前形态；α-半水硫酸钙组明显缺损凹陷，双相生物陶瓷组仍可见少量材料填充覆盖。②X射线观察：α-半水硫酸钙组材料吸收过快，材料降解快于新骨生成，可见骨缺损；α-半水硫酸钙/双相生物陶瓷组骨缺损已愈合，皮质骨塑形良好，骨髓腔完全再通；双相生物陶瓷组仍可见材料影，受未降解材料影响骨缺损未能修复。表明新型α-半水硫酸钙/双相生物陶瓷骨修复材料能明显促进兔桡骨骨缺损的修复，修复效果优于与单独α-半水硫酸钙材料及双相生物陶瓷材料。


中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程


全文链接：

关键词: 生物材料, 骨生物材料, 人工骨, α-半水硫酸钙, 双相生物陶瓷, 骨缺损, X射线

Abstract:

BACKGROUND: Alpha-calcium sulfate hemiydrate/biphasic bioceramics (α-CSH/BCP) as a bone repair material has been widely used in the clinic, but there are still some deficiencies.
OBJECTIVE: To observe the effect of α-CSH/BCP on the repair of bone defects of the radius in rabbits.
METHODS: The unilateral radius of 18 adult New Zealand white rabbits was selected to establish bone defect models, and then these rabbit models were randomized into three groups that were treated with α-CSH, α-CSH/BCP, BCP materials, respectively. At 4, 8, 12 weeks after implantation, bone samples were taken for gross and X-ray observations.
RESULTS AND CONCLUSION: (1) Gross observation: At 12 weeks of implantation, the bone defect was completely repaired in the α-CSH/BCP group, and the defected radius recovered basically; in the α-CSH group, bone defects were visible; and in the BCP group, there was still some material for filling and coverage. (2) X-ray observation: In the α-CSH group, the degradation of implanted materials was faster than new bone formation, and bone defects were visible; in the α-CSH/BCP group, bone defects were healed, cortical bone remodeling was good, and the bone marrow cavity was re-canalized; in the BCP group, the implanted materials were still visible, and bone defects were not repaired. These findings indicate that the α-CSH/BCP bone repair material can significantly promote the repair of bone defects of rabbit radius, with a better repair effect than α-CSH or BCP alone.


中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程


全文链接：

Key words: calcium sulfate, ceramics, X-rays

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