中国组织工程研究 ›› 2013, Vol. 17 ›› Issue (29): 5395-5402.doi: 10.3969/j.issn.2095-4344.2013.29.020
• 生物材料综述 biomaterial review • 上一篇 下一篇
李 莺,李长义
收稿日期:
2013-04-09
修回日期:
2013-04-27
出版日期:
2013-07-22
发布日期:
2013-07-22
通讯作者:
李长义,博士,教授,主任医师,天津医科大学口腔医院,天津市 300070
changyi_li@sina.com
作者简介:
李莺☆,女,1976年生,天津市人,汉族,2011年日本大学松户齿学部毕业,博士,主治医师,主要从事口腔生物材料相关研究。
yingli3051@263.net
基金资助:
天津市高等学校科技发展基金计划项目(20120126)
Li Ying, Li Chang-yi
Received:
2013-04-09
Revised:
2013-04-27
Online:
2013-07-22
Published:
2013-07-22
Contact:
Li Chang-yi, M.D., Professor, Chief physician, Stomatological Hospital of Tianjin Medical University, Tianjin 300070, China
changyi_li@sina.com
About author:
Li Ying☆, M.D., Attending physician, Stomatological Hospital of Tianjin Medical University, Tianjin 300070, China
yingli3051@263.net
Supported by:
the Scientific and Technological Developmental Foundation in Tianjin Universities, No. 20120126*
摘要:
背景:纯钛因具有优良的生物相容性、机械性能和与骨组织相近的弹性模量等被广泛应用于口腔种植领域。 目的:综述近年来钛金属种植体材料表面物理改性、化学改性和生物化学改性策略的研究进展。 方法:以“titanium,implant,surface modification,osseointegration”为检索词,检索PubMed数据库,以“钛,种植体,表面改性,骨整合”为检索词,检索中国知网数据库,限定时间范围为2007年1月至2013年2月。文献检索语种为英文和中文。纳入内容与钛种植体表面改性方法及其对骨整合影响密切相关的文献,排除重复文献。 结果与结论:计算机初检得到199篇文献,根据纳入排除标准,对其中76篇文献进行分析。钛种植体本身是生物惰性材料,通过表面改性对钛金属表面进行活化处理,使之具有生物功能性,与骨组织形成早期骨整合,是国内外口腔种植材料研究的热点问题。物理改性、化学改性和生物化学改性可缩短钛种植体种植周期,获得早期骨整合和更高的结合强度。今后的发展趋势是将多种改性方法有机结合,从分子水平深入研究钛金属材料表面与机体细胞和组织之间的界面分子作用机制,完善种植体的表面改性技术,实现种植体和骨组织的早期和更加稳定的骨整合。
中图分类号:
李 莺,李长义. 钛种植体表面改性策略及对骨整合的影响[J]. 中国组织工程研究, 2013, 17(29): 5395-5402.
Li Ying, Li Chang-yi. Titanium implants: Strategies on surface modification and effect on osseointegration[J]. Chinese Journal of Tissue Engineering Research, 2013, 17(29): 5395-5402.
[1] Kim TI, Jang JH, Kim HW, et al. Biomimetic approach to dental implants. Curr Pharm Des. 2008;14(22):2201-2211.http://www.ncbi.nlm.nih.gov/pubmed/18781972[2] Meswania IM, Bousdras VA, Ahir SP, et al. A novel closed-loop electromechanical stimulator to enhance osseointegration with immediate loading of dental implant restorations. Proc Inst Mech Eng H. 2010;224(10):1221-1232.http://www.ncbi.nlm.nih.gov/pubmed/21138240[3] Avila G, Misch K, Galindo-Moreno P, et al. Implant surface treatment using biomimetic agents. Implant Dent. 2009;18(1):17-26.http://www.ncbi.nlm.nih.gov/pubmed/19212234[4] 孙振,王东.种植体表面改性的现状和发展[J].现代口腔医学杂志,2010,24(2):152-153.http://d.wanfangdata.com.cn/Periodical_xdkqyxzz201002021.aspx[5] 吴应龙,梁剑秋,刘族志,等.纯钛金属种植体表面活性化的处理方法[J].中国组织工程研究与临床康复,2008,12(1):2693-2696.http://www.cnki.net/kcms/detail/detail.aspx?QueryID=5&CurRec=12&DbCode=CJFQ&dbname=CJFD0608&filename=XDKF200814027&uid=WEEvREdiSUtucElBV1VFSHdMbzI1bURpY3NpQjFyM1drbjZ2ZitRd3ErWmhYUTErNG45K2hBWHZTR0JLVWljPQ==[6] Mendonça G, Mendonça DB, Aragão FJ, et al. Advancing dental implant surface technology--from micron- to nanotopography. Biomaterials. 2008;29(28):3822-3835. http://www.ncbi.nlm.nih.gov/pubmed/18617258[7] Cochran DL, Jackson JM, Jones AA, et al. A 5-year prospective multicenter clinical trial of non-submerged dental implants with a titanium plasma-sprayed surface in 200 patients. J Periodontol. 2011;82(7):990-999.http://www.ncbi.nlm.nih.gov/pubmed/21235337[8] Iezzi G, Aprile G, Tripodi D, et al. Implant surface topographies analyzed using fractal dimension. Implant Dent. 2011;20(2):131-138.http://www.ncbi.nlm.nih.gov/pubmed/21448022[9] Park JH, Olivares-Navarrete R, Baier RE, et al. Effect of cleaning and sterilization on titanium implant surface properties and cellular response. Acta Biomater. 2012;8(5):1966-1975.http://www.ncbi.nlm.nih.gov/pubmed/22154860[10] 王瑶,耿威,包生,等.亲水性大颗粒喷砂酸蚀表面种植体骨愈合期的共振频率分析及早期负荷临床探讨[J].口腔医学研究,2012,28(7):694-698.http://www.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&filename=KQYZ201207022&dbname=CJFD2012&dbcode=CJFQ&pr=&urlid=&yx=[11] Cochran DL, Jackson JM, Bernard JP, et al. A 5-year prospective multicenter study of early loaded titanium implants with a sandblasted and acid-etched surface. Int J Oral Maxillofac Implants. 2011;26(6):1324-1332.http://www.ncbi.nlm.nih.gov/pubmed/22167440[12] 孟维艳,周延民,李春艳,等.微米-纳米微结构纯钛表面的细胞及分子生物学研究[J].中国口腔种植学杂志,2011,16(1):8.http://www.cnki.net/KCMS/detail/detail.aspx?QueryID=6&CurRec=1&recid=&filename=KQZZ201101129&dbname=CJFD2011&dbcode=CJFQ&pr=&urlid=&yx=[13] 曹红丹,杨小东,吴大怡,等.钛种植体粗化处理的微形貌观测和表面污染分析[J].生物医学工程学杂志,2007,24(2):372-375.http://www.cnki.com.cn/Article/CJFDTotal-SWGC200702029.htm[14] 陶凤娟,余优成,陈万涛,等.塑性变形纳米化结构对小鼠成骨细胞骨架肌动蛋白影响的研究[J].口腔医学,2009,29(12):617-620.http://www.cnki.com.cn/Article/CJFDTotal-KQYX200912002.htm[15] 吕武龙,刘宏,堵国君,等.阳极氧化TiO2纳米管的制备及其热稳定性的研究[J].口腔颌面修复学杂志,2011,12(2):111-114.http://d.wanfangdata.com.cn/Periodical_kqhmxfxzz201102016.aspx[16] Chung SH, Heo SJ, Koak JY, et al. Effects of implant geometry and surface treatment on osseointegration after functional loading: a dog study. J Oral Rehabil. 2008;35(3):229-236.http://www.ncbi.nlm.nih.gov/pubmed/18254802[17] 王健平,李星海,孟祥才,等.微量元素与钛基种植体微弧氧化陶瓷膜生物活性的关系[J].中国组织工程研究与临床康复,2010,14(3):509-512.http://www.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&filename=XDKF201003036&dbname=CJFD2010&dbcode=CJFQ&pr=&urlid=&yx= [18] 刘媛媛,李果,任家银,等.纳米钛膜种植体-骨界面的骨整合研究[J].国际口腔医学杂志,2012,39(3):312-316.http://www.cnki.net/KCMS/detail/detail.aspx?QueryID=4&CurRec=1&recid=&filename=GWKQ201203010&dbname=CJFD2012&dbcode=CJFQ&pr=&urlid=&yx= [19] Metzler P, von Wilmowsky C, Stadlinger B, et al. Nano-crystalline diamond-coated titanium dental implants - A histomorphometric study in adult domestic pigs. J Craniomaxillofac Surg. In press.http://www.ncbi.nlm.nih.gov/pubmed/3266005[20] Romanos GE, Gupta B, Yunker M, et al. Lasers Use in Dental Implantology. Implant Dent. In press.http://www.ncbi.nlm.nih.gov/pubmed/23571715[21] Oshida Y, Tuna EB, Aktören O, et al. Dental implant systems. Int J Mol Sci. 2010;11(4):1580-1678.http://www.ncbi.nlm.nih.gov/pubmed/20480036[22] Jakse N, Payer M, Tangl S, et al. Influence of low-level laser treatment on bone regeneration and osseointegration of dental implants following sinus augmentation. An experimental study on sheep. Clin Oral Implants Res. 2007;18(4):517-524.http://www.ncbi.nlm.nih.gov/pubmed/17451409[23] Paz MD, álava JI, Goikoetxea L, et al. Biological response of laser macrostructured and oxidized titanium alloy: an in vitro and in vivo study. J Appl Biomater Biomech. 2011;9(3):214-222.http://www.ncbi.nlm.nih.gov/pubmed/22190267[24] Faeda RS, Tavares HS, Sartori R, et al. Evaluation of titanium implants with surface modification by laser beam. Biomechanical study in rabbit tibias. Braz Oral Res. 2009;23(2):137-143.http://www.ncbi.nlm.nih.gov/pubmed/19684947[25] Palmquist A, Grandfield K, Norlindh B, et al. Bone-titanium oxide interface in humans revealed by transmission electron microscopy and electron tomography. J R Soc Interface. 2012;9(67):396-400. http://www.ncbi.nlm.nih.gov/pubmed/21849383[26] Stanford CM. Surface modifications of dental implants. Aust Dent J. 2008;53 Suppl 1:S26-33. http://www.ncbi.nlm.nih.gov/pubmed/18498581[27] Zweymüller KA. Bony ongrowth on the surface of HA-coated femoral implants: an x-ray analysis. Z Orthop Unfall. 2012;150(1):27-31.http://www.ncbi.nlm.nih.gov/pubmed/22009584[28] Subramani K, Jung RE, Molenberg A, et al. Biofilm on dental implants: a review of the literature. Int J Oral Maxillofac Implants. 2009;24(4):616-626.http://www.ncbi.nlm.nih.gov/pubmed/19885401[29] Roy M, Bandyopadhyay A, Bose S. Induction Plasma Sprayed Nano Hydroxyapatite Coatings on Titanium for Orthopaedic and Dental Implants. Surf Coat Technol. 2011;205(8-9):2785-2792.http://www.ncbi.nlm.nih.gov/pubmed/21552358[30] Coelho PG, Cardaropoli G, Suzuki M, et al. Early healing of nanothickness bioceramic coatings on dental implants. An experimental study in dogs. J Biomed Mater Res B Appl Biomater. 2009;88(2):387-393.http://www.ncbi.nlm.nih.gov/pubmed/18395823 [31] Salemi H, Behnamghader A, Afshar A, et al. Biomimetic synthesis of calcium phosphate materials on alkaline-treated titanium. Conf Proc IEEE Eng Med Biol Soc. 2007;2007:5854-5857.http://www.ncbi.nlm.nih.gov/pubmed/18003345[32] 贺刚,陈治清,盛祖立.纯钛种植体表面纳米TiO2生物活性涂层的构建[J].中国口腔种植学杂志,2008,13(3):101-104,135.http://www.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&filename=KQZZ200803002&dbname=CJFD2008&dbcode=CJFQ&pr=&urlid=&yx=[33] Abrishamchian A, Hooshmand T, Mohammadi M, et al. Preparation and characterization of multi-walled carbon nanotube/hydroxyapatite nanocomposite film dip coated on Ti-6Al-4V by sol-gel method for biomedical applications: an in vitro study. Mater Sci Eng C Mater Biol Appl. 2013;33(4):2002-2010.http://www.ncbi.nlm.nih.gov/pubmed/23498225[34] 贺捷,陈万涛,万澎波,等.纳米氧化钛薄膜对颅成骨细胞黏附、增殖的影响[J].口腔医学. 2007,27(9):449-451.http://www.cnki.net/KCMS/detail/detail.aspx?QueryID=6&CurRec=1&recid=&filename=KQYX200709004&dbname=CJFD2007&dbcode=CJFQ&pr=&urlid=&yx=[35] Granato R, Marin C, Suzuki M, et al. Biomechanical and histomorphometric evaluation of a thin ion beam bioceramic deposition on plateau root form implants: an experimental study in dogs. J Biomed Mater Res B Appl Biomater. 2009;90(1):396-403.http://www.ncbi.nlm.nih.gov/pubmed/19107801[36] Coelho PG, Lemons JE. Physico/chemical characterization and in vivo evaluation of nanothickness bioceramic depositions on alumina-blasted/acid-etched Ti-6Al-4V implant surfaces. J Biomed Mater Res A. 2009;90(2):351-361.http://www.ncbi.nlm.nih.gov/pubmed/18508352[37] 王玉琛,孙琛,王家伟,等.电化学沉积钙磷涂层和钙磷-壳聚糖涂层在兔股骨内的长期效应研究[J].口腔医学研究,2010,26(3):320-325.http://www.cnki.net/KCMS/detail/detail.aspx?QueryID=10&CurRec=1&recid=&filename=KQYZ201003008&dbname=CJFD2010&dbcode=CJFQ&pr=&urlid=&yx=[38] Rajesh P, Muraleedharan CV, Komath M, et al. Laser surface modification of titanium substrate for pulsed laser deposition of highly adherent hydroxyapatite. J Mater Sci Mater Med. 2011;22(7):1671-1679. http://www.ncbi.nlm.nih.gov/pubmed/21598038[39] Wang DG, Chen CZ, Ma J, et al. In situ synthesis of hydroxyapatite coating by laser cladding. Colloids Surf B Biointerfaces. 2008;66(2):155-162. http://www.ncbi.nlm.nih.gov/pubmed/18657403[40] Oliveira AL, Reis RL, Li P. Strontium-substituted apatite coating grown on Ti6Al4V substrate through biomimetic synthesis. J Biomed Mater Res B Appl Biomater. 2007;83(1):258-265.http://www.ncbi.nlm.nih.gov/pubmed/17455267[41] Santander S, Alcaine C, Lyahyai J, et al. In vitro osteoinduction of human mesenchymal stem cells in biomimetic surface modified titanium alloy implants. Dent Mater J. 2012;31(5):843-850.http://www.ncbi.nlm.nih.gov/pubmed/23037849[42] Meirelles L, Arvidsson A, Andersson M, et al. Nano hydroxyapatite structures influence early bone formation. J Biomed Mater Res A. 2008;87(2):299-307. http://www.ncbi.nlm.nih.gov/pubmed/18181110 [43] Meirelles L, Albrektsson T, Kjellin P, et al. Bone reaction to nano hydroxyapatite modified titanium implants placed in a gap-healing model. J Biomed Mater Res A. 2008;87(3):624-631.http://www.ncbi.nlm.nih.gov/pubmed/18189300[44] Gu YX, Du J, Si MS, et al. The roles of PI3K/Akt signaling pathway in regulating MC3T3-E1 preosteoblast proliferation and differentiation on SLA and SLActive titanium surfaces. J Biomed Mater Res A. 2013;101(3):748-754.http://www.ncbi.nlm.nih.gov/pubmed/22941963[45] Wall I, Donos N, Carlqvist K, et al. Modified titanium surfaces promote accelerated osteogenic differentiation of mesenchymal stromal cells in vitro. Bone. 2009;45(1):17-26.http://www.ncbi.nlm.nih.gov/pubmed/19332166[46] 于晓琳,邓飞龙,宁成云,等.新型氨基化纳米多孔钛表面的生物相容性研究[J].口腔医学研究,2012,28(7):656-659.http://www.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&filename=KQYZ201207010&dbname=CJFD2012&dbcode=CJFQ&pr=&urlid=&yx=[47] 余森,于振涛,韩建业,等.多孔Ti3Zr2Sn3Mo25Nb钛合金表面活性次级微孔涂层的制备及其成骨性能[J].中国表面工程,2012,25(6):101-106.http://www.cnki.net/KCMS/detail/detail.aspx?QueryID=4&CurRec=1&recid=&filename=BMGC20121123001&dbname=CAPJ2012&dbcode=CJFQ&pr=&urlid=&yx=[48] Wang H, Liang C, Yang Y, et al. Bioactivities of a Ti surface ablated with a femtosecond laser through SBF. Biomed Mater. 2010;5(5):054115.http://www.ncbi.nlm.nih.gov/pubmed/20876953[49] 李志安.牙科钛种植体表面改性[J].中国实用口腔科杂志,2010,3(8):457-461.http://www.cnki.net/KCMS/detail/detail.aspx?QueryID=8&CurRec=1&recid=&filename=ZSKQ201008005&dbname=CJFD2010&dbcode=CJFQ&pr=&urlid=&yx=[50] Dohan Ehrenfest DM, Coelho PG, Kang BS, et al. Classification of osseointegrated implant surfaces: materials, chemistry and topography. Trends Biotechnol. 2010;28(4):198-206. http://www.ncbi.nlm.nih.gov/pubmed/ 20116873[51] Amin HD, Olsen I, Knowles JC, et al. Differential effect of amelogenin peptides on osteogenic differentiation in vitro: identification of possible new drugs for bone repair and regeneration. Tissue Eng Part A. 2012;18(11-12):1193-1202. http://www.ncbi.nlm.nih.gov/pubmed/22320389[52] Lee JY, Choo JE, Choi YS, et al. Assembly of collagen-binding peptide with collagen as a bioactive scaffold for osteogenesis in vitro and in vivo. Biomaterials. 2007;28(29):4257-4267.http://www.ncbi.nlm.nih.gov/pubmed/17604098 [53] Pek YS, Gao S, Arshad MS, et al. Porous collagen-apatite nanocomposite foams as bone regeneration scaffolds. Biomaterials. 2008;29(32):4300-4305.http://www.ncbi.nlm.nih.gov/pubmed/8706690[54] Stadlinger B, Pilling E, Huhle M, et al. Suitability of differently designed matrix-based implant surface coatings: an animal study on bone formation. J Biomed Mater Res B Appl Biomater. 2008;87(2):516-524.http://www.ncbi.nlm.nih.gov/pubmed/18546193[55] Ravichandran R, Ng CCh, Liao S, et al. Biomimetic surface modification of titanium surfaces for early cell capture by advanced electrospinning. Biomed Mater. 2012;7(1):015001.http://www.ncbi.nlm.nih.gov/pubmed/22156014 [56] Liu L, Chen G, Chao T, et al. Reduced foreign body reaction to implanted biomaterials by surface treatment with oriented osteopontin. J Biomater Sci Polym Ed. 2008;19(6):821-835. http://www.ncbi.nlm.nih.gov/pubmed/18534099[57] Rapuano BE, Hackshaw KM, Schniepp HC, et al. Effects of coating a titanium alloy with fibronectin on the expression of osteoblast gene markers in the MC3T3 osteoprogenitor cell line. Int J Oral Maxillofac Implants. 2012;27(5):1081-1090.http://www.ncbi.nlm.nih.gov/pubmed/23057020[58] 吴倩雯,郑元俐,黄慧,等.钛种植体表面生物化学改性的研究进展[J].口腔颌面修复学杂志,2009,10(2):116-118.http://www.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=2&recid=&filename=KHXF200902017&dbname=CJFD2009&dbcode=CJFQ&pr=&urlid=&yx=[59] 唐霞,王少安.种植体的表面改性与促进成骨[J].国际口腔医学杂志,2008,35 Suppl:225-228.http://www.cnki.net/KCMS/detail/detail.aspx?QueryID=4&CurRec=4&recid=&filename=GWKQ2008S1087&dbname=CJFD2008&dbcode=CJFQ&pr=&urlid=&yx=[60] Nie H, Soh BW, Fu YC, et al. Three-dimensional fibrous PLGA/HAp composite scaffold for BMP-2 delivery. Biotechnol Bioeng. 2008;99(1):223-234.http://www.ncbi.nlm.nih.gov/pubmed/17570710 [61] Razzouk S, Sarkis R. BMP-2: biological challenges to its clinical use. N Y State Dent J. 2012;78(5):37-39.http://www.ncbi.nlm.nih.gov/pubmed/23082692[62] Miljkovic ND, Cooper GM, Hott SL, et al. Calcium aluminate, RGD-modified calcium aluminate, and beta-tricalcium phosphate implants in a calvarial defect. J Craniofac Surg. 2009;20(5):1538-1543.http://www.ncbi.nlm.nih.gov/pubmed/19816293[63] Avila G, Misch K, Galindo-Moreno P, et al. Implant surface treatment using biomimetic agents. Implant Dent. 2009;18(1):17-26. http://www.ncbi.nlm.nih.gov/pubmed/19212234[64] Brinkmann J, Hefti T, Schlottig F, et al. Response of osteoclasts to titanium surfaces with increasing surface roughness: an in vitro study. Biointerphases. 2012;7(1-4):34. http://www.ncbi.nlm.nih.gov/pubmed/22639093 [65] Hyzy SL, Olivares-Navarrete R, Hutton DL, et al. Microstructured titanium regulates interleukin production by osteoblasts, an effect modulated by exogenous BMP-2. Acta Biomater. 2013;9(3):5821-5829.http://www.ncbi.nlm.nih.gov/pubmed/23123301[66] Gittens RA, McLachlan T, Olivares-Navarrete R, et al. The effects of combined micron-/submicron-scale surface roughness and nanoscale features on cell proliferation and differentiation. Biomaterials. 2011;32(13):3395-3403.http://www.ncbi.nlm.nih.gov/pubmed/21310480[67] Ogawa T, Saruwatari L, Takeuchi K, et al. Ti nano-nodular structuring for bone integration and regeneration. J Dent Res. 2008;87(8):751-756.http://www.ncbi.nlm.nih.gov/pubmed/18650547[68] Guo J, Padilla RJ, Ambrose W, et al. The effect of hydrofluoric acid treatment of TiO2 grit blasted titanium implants on adherent osteoblast gene expression in vitro and in vivo. Biomaterials. 2007;28(36):5418-5425.http://www.ncbi.nlm.nih.gov/pubmed/17868850 [69] Park JH, Wasilewski CE, Almodovar N, et al. The responses to surface wettability gradients induced by chitosan nanofilms on microtextured titanium mediated by specific integrin receptors. Biomaterials. 2012;33(30):7386-7393.http://www.ncbi.nlm.nih.gov/pubmed/22835642 [70] Beyeler M, Schild C, Lutz R, et al. Identification of a fibronectin interaction site in the extracellular matrix protein ameloblastin. Exp Cell Res. 2010;316(7):1202-1212.http://www.ncbi.nlm.nih.gov/pubmed/20043904[71] Matsuzawa M, Sheu TJ, Lee YJ, et al. Putative signaling action of amelogenin utilizes the Wnt/beta-catenin pathway. J Periodontal Res. 2009;44(3):289-296.http://www.ncbi.nlm.nih.gov/pubmed/19462488[72] Yan XZ, Rathe F, Gilissen C, et al. The effect of enamel matrix derivative (Emdogain?) on gene expression profiles of human primary alveolar bone cells. J Tissue Eng Regen Med. In press.http://www.ncbi.nlm.nih.gov/pubmed/22689476[73] Sverzut AT, Crippa GE, Morra M, et al. Effects of type I collagen coating on titanium osseointegration: histomorphometric, cellular and molecular analyses. Biomed Mater. 2012;7(3):035007.http://www.ncbi.nlm.nih.gov/pubmed/22406648[74] Sena K, Sumner DR, Virdi AS. Effect of recombinant human transforming growth factor-beta2 dose on bone formation in rat femur titanium implant model. J Biomed Mater Res A. 2010;92(3):1210-1217.http://www.ncbi.nlm.nih.gov/pubmed/19322883[75] Secchi AG, Grigoriou V, Shapiro IM, et al. RGDS peptides immobilized on titanium alloy stimulate bone cell attachment, differentiation and confer resistance to apoptosis. J Biomed Mater Res A. 2007;83(3):577-584.http://www.ncbi.nlm.nih.gov/pubmed/17503524[76] Cao X, Yu WQ, Qiu J, et al. RGD peptide immobilized on TiO2 nanotubes for increased bone marrow stromal cells adhesion and osteogenic gene expression. J Mater Sci Mater Med. 2012;23(2):527-536.http://www.ncbi.nlm.nih.gov/pubmed/22143905 |
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1.1 资料检索
1 通过钛金属表面改性而使其更好的与骨组织形成生物性结合,是口腔种植材料缩短种植周期,获得早期骨整合和更高的结合强度研究的热点之一。 2 文章从物理改性,化学改性和生物化学改性3方面分析了钛种植体表面改性的策略,全面介绍了最新的修饰方法以及种植体表面改性对于骨整合影响的研究现状,旨在为探索更为有效的种植体表面改性方法,促进早期骨整合和更高的结合强度提供理论依据。 3 单一的钛金属种植体材料表面改性和简单的制备工艺已不能满足目前的临床要求,结合物理、化学、生物化学方法及材料优点的改性技术是今后提高种植体表面活性的必然趋势。
钛金属种植体材料的表面改性的方法多种多样,其目的均是为了实现骨-种植体界面的早期骨整合,使种植体实现更好的生物固定,并尽早发挥功能。单一的改性和简单的制备工艺已不能满足不断提高的临床要求,能够结合上述方法及材料优点的改性技术是今后提高种植体表面活性的必然趋势。今后将进一步从分子水平研究材料表面与机体细胞和组织之间的界面作用,探索不同表面处理方式促进骨整合的机制,从基因水平深刻揭示影响细胞黏附、生长、增殖、分化等功能调控和组织形成的机制。通过上述机制的深入解读,有望进一步完善种植体的表面改性技术,促进种植体和骨组织形成早期和更加稳定的骨整合。
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