中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (49): 9253-9256.doi: 10.3969/j.issn.2095-4344.2012.49.024

• 干细胞临床实践 clinical practice of stem cells • 上一篇    下一篇

地西他滨联合造血干细胞移植治疗骨髓增生异常综合征转化急性白血病

李旭东,何 易,胡 元,肖若芝,方志刚,郑永江,刘加军,林东军   

  1. 中山大学血液病研究所,中山大学附属第三医院血液内科,广东省广州市 510630
  • 收稿日期:2012-03-29 修回日期:2012-04-26 出版日期:2012-12-02 发布日期:2012-12-02
  • 通讯作者: 林东军,硕士,教授,博士生导师,中山大学血液病研究所,中山大学附属第三医院血液内科,广东省广州市 510630 lindongjun0168@163.com
  • 作者简介:李旭东★,女,1974年生,内蒙古自治区乌盟人,汉族,2001年中山医科大学毕业,硕士,主治医师,主要从事造血干细胞移植治疗恶性血液病及白血病化疗方面的研究。 Lixudong0323@sohu.com

Decitabine application combined with allogeneic hematopoietic stem cell transplantation for treatment of acute leukemia progressed from myelodysplastic syndrome

Li Xu-dong, He Yi, Hu Yuan, Xiao Ruo-zhi, Fang Zhi-gang, Zheng Yong-jiang, Liu Jia-jun, Lin Dong-jun   

  1. Department of Hematology, Third Affiliated Hospital of Sun Yat-sen University, Hematopathy Institute of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China
  • Received:2012-03-29 Revised:2012-04-26 Online:2012-12-02 Published:2012-12-02
  • Contact: Lin Dong-jun, Master, Professor, Doctoral supervisor, Department of Hematology, Third Affiliated Hospital of Sun Yat-sen University, Hematopathy Institute of Sun Ya-sen University, Guangzhou 510630, Guangdong Province, China lindongjun0168@163.com
  • About author:Li Xu-dong★, Master, Attending physician, Department of Hematology, Third Affiliated Hospital of Sun Yat-sen University, Hematopathy Institute of Sun Ya-sen University, Guangzhou 510630, Guangdong Province, China Lixudong0323@sohu.com

摘要:

背景:由骨髓增生异常综合征转化的急性白血病为难治白血病,临床疗效差,缓解率低,生存期短,因此探索新的有效治疗方法极为重要。
目的:观察地西他滨联合造血干细胞移植治疗骨髓增生异常综合征转化急性白血病的临床疗效及并发症。
方法:骨髓增生异常综合征转化的急性髓细胞白血病患者1例,先后予2个疗程地西他滨及异基因造血干细胞移植,观察临床疗效、地西他滨的毒副作用及移植相关并发症。
结果与结论:经2个疗程地西他滨治疗后,达到完全缓解,主要不良反应为骨髓抑制并发感染,该患者再接受异基因造血干细胞移植后获得无病生存213 d,移植过程中出现急性移植物抗宿主病及肺部感染。结果提示地西他滨联合造血干细胞移植治疗骨髓增生异常综合征转化急性白血病获得良好效果,毒副作用及相关并发症可控制,为临床上骨髓增生异常综合征转化急性白血病的治疗提供了新方法。

关键词: 地西他滨, 造血干细胞移植, 骨髓增生异常综合征, 转化, 白血病

Abstract:

BACKGROUND: Acute leukemia progressed from myelodysplastic syndrome is a refractory disease with poor clinical therapeutic effect, low remission rate and short survival period. Therefore, it is extremely important to explore a new and effective treatment method.
OBJECTIVE: To investigate the clinical therapeutic effects and complications of decitabine application combined with allogeneic hematopoietic stem cell transplantation in treatment of acute leukemia progressed from myelodysplastic syndrome.
METHODS: One patient with acute leukemia progressed from myelodysplastic syndrome received two courses of decitabine application combined with allogeneic hematopoietic stem cell transplantation. Clinical curative effects, the side effects of decitabine and the complications of allogeneic hematopoietic stem cell transplantation were investigated.
RESULTS AND CONCLUSION: The patient achieved complete remission after two courses of decitabine application combined with allogeneic hematopoietic stem cell transplantation with infection and myelosuppresison. The patient lived without disease for 213 days although acute graft-versus-host disease and pulmonary infection occurred after decitabine application combined with allogeneic hematopoietic stem cell transplantation. These findings suggest that decitabine application combined with allogeneic hematopoietic stem cell transplantation is an effective method to treat acute leukemia progressed from myelodysplastic syndrome, and the side effects and complications can be well controlled.

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