中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (46): 8733-8740.doi: 10.3969/j.issn.2095-4344.2012.46.036

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    

运动状态下脂肪氧化的调节

胡 艳1，牛 洁2   

  1. 1东南大学体育系，江苏省南京市 210042
    2 解放军理工大学指挥军官基础教育学院，江苏省南京市 211101
  • 收稿日期:2012-08-19 修回日期:2012-09-11 出版日期:2012-11-11 发布日期:2012-11-11
  • 作者简介:胡艳★，女，1975年生，江苏省新沂市人，汉族，1997年南京体育学院毕业，硕士，讲师，主要从事运动训练学方面的研究。 huyan318@163.com

Regulation mechanism underlying fatty acid oxidation during exercise

Hu Yan1, Niu Jie2   

  1. 1Department of Sports, the Southeast University, Nanjing 210014, Jiangsu Province, China
    2Department of Military Education and Training, the Basic College of Science, the PLA University of Science and Technology, Nanjing 211101, Jiangsu Province, China
  • Received:2012-08-19 Revised:2012-09-11 Online:2012-11-11 Published:2012-11-11
  • About author:Hu Yan★, Master, Lecturer, Department of Sports, the Southeast University, Nanjing 210014, Jiangsu Province, China huyan318@163.com

PDF

409

被引次数

2

摘要：

背景：传递到工作肌群血浆中的脂肪酸主要来自于储存在脂肪组织中的三酰甘油的分解。在大强度运动时，脂肪酸氧化不能支持能量的需要，可能是骨骼肌氧化脂肪酸能力受限。
目的：综述运动时脂肪氧化调节机制方面的研究，提出目前脂肪氧化调节机制方面亟待解决的问题。
方法：以“exercise，fatty acid oxidation，intensity，carnitine，acetylcarnitine，mitochondria”为检索词，检索PubMed数据库1995至2012年发表的相关文章，文献语种限制为英文。纳入与运动时脂肪氧化调节机制相关的内容，排除重复性研究。
结果与结论：计算机初检得到94篇文献，排除无关重复的文献，保留56篇进行综述。运动时脂肪酸氧化存在多种可能调节的步骤，从脂肪组织脂肪分解到骨骼肌线粒体的代谢。目前，最有吸引力的脂肪酸氧化调节候选剂是肌肉代谢物肉碱。它是肉毒碱棕榈酰转移酶1调节和脂肪酸氧化的基本。大强度运动时，糖酵解迅速增加，为线粒体提供过多乙酰辅酶A，并被肉碱缓冲，生成乙酰肉碱。相应地，肌肉自由肉碱下降，降低肉毒碱棕榈酰转移酶1活性，从而降低运输脂肪酸进入线粒体的能力，也降低脂肪酸氧化率。因此，糖原迅速分解和糖酵解对抑制脂肪酸的氧化产生主要影响。

关键词: 运动, 脂肪酸氧化, 肉碱, 乙酰肉碱, 线粒体, 代谢, 乙酰辅酶A, 肉毒碱棕榈酰转移酶1, β氧化, 骨骼肌, 能量代谢

Abstract:

BACKGROUND: The plasma fatty acid to the working muscle is primarily supplied from lipolysis of triacylglycerol stored in adipose tissue. The inability of fatty acid oxidation to support the energy demand during high intensity exercise can reflect a limitation in skeletal muscle to oxidize fatty acids.
OBJECTIVE: To review findings of research on which related to the regulation mechanism about fatty acid oxidation during exercise, and to propose the problems that need to be solved on mechanism about fatty acid oxidation.
METHODS: The PubMed database was used to search the articles on the regulation mechanism about fatty acid oxidation during exercise published from 1995 to 2012 with the key words of “exercise, fatty acid oxidation, intensity, carnitine, acetylcarnitine, mitochondria” in English. The repetitive contents were deleted.
RESULTS AND CONCLUSION: A total of 94 articles were collected after the initial search, the repetitive contents were deleted, and finally 56 articles were classified and sorted. Fatty acid oxidation during exercise involves multiple possible regulatory steps, ranging from adipose tissue lipolysis to mitochondrial metabolism in skeletal muscle. It seems that the most attractive regulatory candidate for fatty acid oxidation is the muscle metabolite carnitine, which is essential in carnitine palmitoyl transferase-1 regulation and fatty acid oxidation. At high intensity exercise, the rapid glycolysis provides the mitochondria with excess Acetyl coenzyme A which buffered by free carnitine to form acetylcarnitine. Accordingly, a fall in muscle concentration of free carnitine may reduce carnitine palmitoyl transferase-1 activity, and thus the ability to transport fatty acid into the mitochondria, and therefore also the rate of fatty acid oxidation. In this way, rapid glycogen decomposition and glycolysis are suggested to have a major impact on inhibiting fatty acid oxidation.

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