中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (43): 8127-8132.doi: 10.3969/j.issn.2095-4344.2012.43.030

• 生物材料综述 biomaterial review • 上一篇    下一篇

壳聚糖基聚电解质的生物医用前景

张 乱1，黄 霞1，2，杨庆良1，扬 扬2，申长雨2   

  1. 1郑州大学材料科学与工程学院，河南省郑州市 450001
    2郑州大学橡塑模具工程中心，河南省郑州市 450002
  • 收稿日期:2012-03-02 修回日期:2012-04-16 出版日期:2012-10-21 发布日期:2012-10-21
  • 作者简介:张乱★，女，1988年生，河南省周口市人，汉族，郑州大学在读硕士，主要从事壳聚糖聚电解质生物医用性研究。 happyhxia@ 163.com

Biomedical application of chitosan-based polyelectrolyte hydrogels

Zhang Luan1, Huang Xia1, 2, Yang Qing-liang1, Yang Yang2, Shen Chang-yu2   

  1. 1School of Material Science and Engineering, Zhengzhou University, Zhengzhou 45000, Henan Province, China
    2National Engineering Research Center for Advanced Polymer Processing Technology, Zhengzhou University, Zhengzhou 45000, Henan Province, China
  • Received:2012-03-02 Revised:2012-04-16 Online:2012-10-21 Published:2012-10-21
  • About author:Zhang Luan★, Studying for master’s degree, School of Material Science and Engineering, Zhengzhou University, Zhengzhou 450001, Henan Province, China happyhxia@163.com

PDF

710

被引次数

5

摘要：

背景：利用壳聚糖阳离子聚合物特性，以不使用化学交联剂为前提在温和条件下制得的壳聚糖基聚电解质复合物，具有良好的生物相容性。
目的：综述近年来壳聚糖基聚电解质在药物载体、组织工程、伤口敷料、生物传感器、基因载体等方面的应用情况。
方法：由第一作者检索2004至2011年 ACS数据库和Elsevier Science电子期刊有关壳聚糖聚电解质在生物医用领域中的应用，尤其在药物载体、组织工程、伤口敷料、生物传感器及基因载体中的研究情况。
结果与结论：壳聚糖本身由于生物相容性好，可应用于生物体中作为良好的载体材料、支架材料、伤口敷料及生物传感器，经过与其他阴离子物质复合后可以保护壳聚糖本身良好性质，并且避免了使用化学交联剂所带来的生物毒性。壳聚糖的阳离子聚电解质本性使其能与黏液、阴离子表面和其他大分子如DNA产生强静电作用可有效应用于药物传送、基因治疗、固定生物酶等；壳聚糖聚电解质凝胶独特的性质如pH值、离子强度、电场敏感性，可使其通过对外界环境的改变作出不同响应，实现对生物组织的模拟、刺激响应药物控释，并且壳聚糖具备优异的抗菌性、止血性、亲水性和透气性，能够有效促进伤口愈合。

关键词: 壳聚糖, 水凝胶, 聚电解质, 生物医用, 生物材料, 综述文献

Abstract:

BACKGROUND: Chitosan-based polyelectrolyte complexes are prepared on the basis of the property of cationic polymer without using chemical cross-linking agent and under mild conditions. They have good biocompatibility.
OBJECTIVE: To review the application of chitosan-based polyelectrolyte in drug carrier, tissue engineering, wound dressing, biosenser and gene carrier.
METHODS: ACS database and Elsevier Science electronic journal were searched by the first author for papers concerning the application of chitosan-based polyelectrolyte in bio-medical fields (2004/2011), especially the studies in drug carrier, tissue engineering, wound dressing, biosenser due to its good biocompatibility
RESULTS AND CONCLUSION: Chitosan can be applied in drug carrier, tissue engineering, wound dressing, biosenser and gene carrier. After it is compounded with other anions, the complexes can keep the good properties of chitosan, and avoid the biotoxicity produced by using chemical cross-linking agent. Chitosan-based polyelectrolyte can have strong electrostatic effect with grume, anionic surface and other giant molecules such as DNA, which can be effectively used in drug deliver, gene therapy and immobilized enzyme. Owing to the special properties of chitosan-based polyelectrolyte glue, such as pH value, ionic strength and electric field sensitivity, it can respond to the changes of external environment and realize the imitation of biological tissues as well as the stimulation of drug controlled release. Besides, chitosan has excellent bacterinertness, hemostatic, hydrophilicity and ventilation properties, which can promote wound healing effectively.

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