中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (38): 7207-7210.doi: 10.3969/j.issn.2095-4344.2012.38.033

• 生物材料临床实践 clinical practice of biomaterials • 上一篇    下一篇

胶体磷酸铬32P放射治疗膝关节滑膜炎：28例随访

朱 越，赵金忠，袁志斌，腾 跃   

  1. 上海市第六人民医院，上海市 200233
  • 收稿日期:2012-01-15 修回日期:2012-03-29 出版日期:2012-09-16 发布日期:2012-09-16
  • 作者简介:朱越★，男， 1974年生，江苏省武进县人，汉族，2000年上海医科大学毕业，硕士，主治医生，主要从事关节镜研究。 zhuyue999999@yahoo.com.cn

Intra-articular radioisotope of 32P-colloidal chromic phosphate for knee joint synovitis: A follow-up of 28 cases

Zhu Yue, Zhao Jin-zhong, Yue Zhi-bin, Teng Yue   

  1. Department of Orthopedics, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
  • Received:2012-01-15 Revised:2012-03-29 Online:2012-09-16 Published:2012-09-16
  • About author:Zhu Yue★, Master, Attending physician, Department of Orthopedics, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China zhuyue999999@ yahoo.com.cn

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摘要：

背景：可以用来治疗滑膜炎的核素种类繁多，物理特性差异较大。
目的：观察采用胶体磷酸铬32P关节腔内放射治疗膝关节滑膜炎的近期疗效。
方法：2008-01/2009-12采用胶体磷酸铬32P关节腔内放射治疗膝关节滑膜炎28例，比较患膝治疗前后的MRI影像、主动活动度和Lysholm膝关节评分变化。
结果与结论：患者治疗后随访均超过14个月。MRI显示关节内滑膜增生情况有不同程度的好转。Lysholm评分从术前的59.05±11.90提高至随访时的80.22±10.16(P < 0.01)，优良率为86%。膝关节主动活动度从治疗前(82.78±11.01)°提高至(107.50±11.66)°(P < 0.01)。除有2例患者自觉肿痛症状较治疗前无明显改善外，所有患者均未见感染、关节僵硬、深静脉血栓及软组织坏死等并发症。表明胶体磷酸铬32P关节腔内放射治疗膝关节滑膜炎是一种安全有效的方法。

关键词: 胶体磷酸铬32P, 放射性同位素, 膝关节, 滑膜炎, MRI, Lysholm评分

Abstract:

BACKGROUND: At present, there are various kinds of nuclides for knee joint synovitis, but their physical characteristics have obvious differences.
OBJECTIVE: To investigate the short-term effect of the intra-articular radioaction of 32P-colloidal chromic phosphate on knee joint synovitis.
METHODS: From January 2008 to December 2009, 28 cases (28 knees) of knee joint synovitis were included and treated with the intra-articular radioisotope of 32P-colloidal chromic phosphate. Their MRI images, active range of motion, Lysholm scores of knee joint before and after treatment were compared.
RESULTS AND CONCLUSION: The period of follow-up was from 14 to 24 months (mean 20.8 months). MRI examination of follow-up showed that synovial hyperplasia was obviously improved in various degrees. Lysholm scores of knee joint were increased from 59.05±11.90 to 80.22±10.16 (P < 0.01); excellent and good rate was 85.7%, as well as active range of motion was increased from (82.78±11.01)° to (107.50°±11.66)° (P < 0.01). Of all the cases, only two cases had no obvious improvement in subjective gall symptoms after treatment, and the rest cases were not found infection, anchylosis, deep venous thrombosis and death of body tissue. These findings suggest that the intra-articular radioisotope of 32P-colloidal chromic phosphate for knee joint synovitis is a safe and effective method.

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