中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (38): 7126-7130.doi: 10.3969/j.issn.2095-4344.2012.38.020

• 药物控释材料 drug delivery materials • 上一篇    下一篇

长效缓释双药物人工骨的制备及释放特性

鲍玉成，张文龙，王 勇，张 洁   

  1. 天津市海河医院，天津市呼吸疾病研究所，天津市 300350
  • 收稿日期:2012-04-20 修回日期:2012-05-30 出版日期:2012-09-16 发布日期:2012-09-16
  • 通讯作者: 王勇，正高级工程师，天津市海河医院，天津市呼吸疾病研究所，天津市 300350 tjs.hhyywy@ yahoo.com.cn
  • 作者简介:鲍玉成，男，1975年生，天津市人，汉族，1999年天津市医科大学毕业，主要从事骨科(以骨结核为主的骨病)研究。

Preparation and release features of long-term slow-release two-component drug artificial bone

Bao Yu-cheng, Zhang Wen-long, Wang Yong, Zhang Jie   

  1. Tianjin Haihe Hospital, Tianjin Respiratory Disease Research Institute, Tianjin 300350, China
  • Received:2012-04-20 Revised:2012-05-30 Online:2012-09-16 Published:2012-09-16
  • Contact: Wang Yong, Senior engineer, Tianjin Haihe Hospital, Tianjin Respiratory Disease Research Institute, Tianjin 300350, China tjs.hhyywy@ yahoo.com.cn
  • About author:Bao Yu-cheng, Tianjin Haihe Hospital, Tianjin Respiratory Disease Research Institute, Tianjin 300350, China

PDF

514

被引次数

12

摘要：

背景：利用可降解缓释生物材料包载利福平或异烟肼制成50 μm以下的缓释降解肺靶向微球已多有报道，主要用于静脉注射肺靶向治疗研究。
目的：研制长效缓释双组分药物人工骨，筛选最佳制备工艺并行体外释药特性观察。
方法：采用乳剂-溶剂挥发法正交设计优化制备工艺，分别制备利福平聚乳酸-羟基乙醇共聚物微球和异烟肼聚乳酸-羟基乙醇共聚物微球。利用生物黏合剂将两种微球加工成长效缓释双组分药物人工骨。
结果与结论：按照优化工艺分别制得聚乳酸-羟基乙醇共聚物载利福平26%、异烟肼28%的微球，并按质量各50%制成人工骨，体外释放90 d保持0.02，0.03 mg/L药物浓度。表明该人工骨有望为骨结核治疗用提供一种新型的方法。

关键词: 聚乳酸-羟基乙醇, 微球体, 药物释放, 利福平, 异烟肼

Abstract:

BACKGROUND: Studies have shown that rifampicin or isoniazid covered with biodegradable sustained release materials can be used to prepare pulmonary targeting microspheres with less than 50 μm sustained-release degradation, which are mainly used for lung targeted therapy via the intravenous injection.
OBJECTIVE: To develop long-term slow-release two-component drug artificial bone and to select the optimal preparation process of drug release as well as to observe the characteristics of in vitro releases.
METHODS: Orthogonal design was adopted to optimize the preparation technology using the emulsion-solvent evaporation method of preparation technology. We prepared rifampicin poly(lactic-co-glycolic acid) copolymer microspheres and isoniazid poly(lactic-co-glycolic acid) copolymer microspheres. Biological binder was used to process these two kinds of microspheres into long-term slow-release two-component drug artificial bone.
RESULTS AND CONCLUSION: According to the process optimization, two kinds of poly(lactic-co-glycolic acid) copolymer microspheres carrying 26% rifampicin or 28% isoniazid were prepared successfully, which were used to prepare artificial bone at a quality of 50%. The drug concentrations were kept at 0.02 and 0.03 mg/L after 90 days of in vitro release. These findings indicate that this kind of artificial bone is expected to provide a new and effective treatment for bone tuberculosis.

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