中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (37): 7015-7019.doi: 10.3969/j.issn.2095-4344.2012.37.034

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

丝裂原活化蛋白激酶信号通路对骨关节炎软骨的作用

范素芳1，王文雅1，张 柳2   

  1. 1河北联合大学病理教研室，河北省唐山市 063000
    2河北联合大学附属医院骨外科，河北省唐山市 063000
  • 收稿日期:2012-01-04 修回日期:2012-01-15 出版日期:2012-09-09 发布日期:2012-09-09
  • 通讯作者: 王文雅，教授，硕士生导师，河北联合大学病理教研室，河北省唐山市 063000 wangwenya-3@126.com
  • 作者简介:范素芳★，女，1982年生，河北省石家庄市人，汉族，河北联合大学在读硕士，主要从事骨性关节炎的研究。 964013115@qq.com

Effect of mitogen-activated protein kinases signaling pathway on osteoarthritis cartilage

Fan Su-fang1, Wang Wen-ya1, Zhang Liu2   

  1. 1Department of Pathology, Hebei United University, Tangshan 06300, Hebei Province, China
    2Department of Orthopedic Surgery, Affiliated Hospital of Hebei United University, Tangshan 06300, Hebei Province, China
  • Received:2012-01-04 Revised:2012-01-15 Online:2012-09-09 Published:2012-09-09
  • Contact: Wang Wen-ya, Master’s supervisor, Professor, Department of Pathology, Hebei United University, Tangshan 06300, Hebei Province, China wangwenya-3@126.com
  • About author:Fan Su-fang★, Studying for master’s degree, Department of Pathology, Hebei United University, Tangshan 06300, Hebei Province, China 964013115@qq.com

PDF

401

被引次数

20

摘要：

背景：骨关节炎的主要病理过程是软骨损伤，而软骨细胞间信号转导的异常是软骨损伤的重要因素。
目的：综合分析丝裂原活化蛋白激酶信号通路的最新进展，进一步分析丝裂原活化蛋白激酶信号转导通路在骨关节炎软骨中的作用。
方法：由第一作者用计算机检索中国期刊全文数据库(CNKI：1990/2011)和Pubmed数据库(1990/2011)，检索词分别为骨性关节炎，关节软骨，ERK，JNK，P38，MAPK signaling palhway，osteoarthritis, chondrocytes，语言分别设定为中文和英文。纳入有关MAPKs信号通路及其相关蛋白激酶对骨关节炎软骨作用的研究，排除重复性研究。
结果与结论：保留32篇文献进一步分析。结果发现，丝裂原活化蛋白激酶信号转导通路在细胞内具有生物进化的高度保守性，通过保守的三级酶促级联反应激活转录因子，调节特定的基因表达。目前已证实，丝裂原活化蛋白激酶信号参与并调控关节软骨中软骨细胞的增殖、分化、凋亡，而丝裂原活化蛋白激酶信号的失调在骨关节炎的发生、发展中扮演着十分重要的角色。明确丝裂原活化蛋白激酶信号通路在骨关节炎发病机制中的确切作用将有助于骨性关节炎的靶向治疗。

关键词: 骨关节炎, 软骨细胞, 丝裂原活化蛋白激酶, P38激酶, 细胞外信号调节蛋白激酶, c-jun N-末端激酶

Abstract:

BACKGROUND: Articular cartilage degeneration is considered to be the main pathological change in osteoarthritis, and abnormal cartilage signal transduction is the key factor in articular cartilage degeneration.
OBJECTIVE: To review the updated progresses of mitogen-activated protein kinases (MAPK) signaling pathway and to further analyze the role of MAPKs pathway in osteoarthritis cartilage．
METHODS: First author searched literatures from CNKI and PubMed databases from 1990 to 2011, using the key words of “osteoarthritis, articular cartilage, ERK, JNK, P38, MAPK signaling pathway” in Chinese and English, respectively. Articles related to MAPK signaling pathway and the effect of MAPK signaling pathway on osteoarthritis cartilage were included. Reproducibility articles were excluded.
RESULTS AND CONCLUSION: Of 120 articles retrieved, 32 were selected according to the inclusive and exclusive criteria. The results showed that MAPKs pathway was a highly conserved signaling mechanism via conservative three degree of enzyme promoting cascade reactions (MAPKKK→MAPKK→MAPK) to activate transcription factor and regulate specific gene expression. It is proved that MAPKs pathway participates in regulating chondrocyte proliferation, differentiation and apoptosis in the articular cartilage, and maladjustment in MAPKs pathway plays a key role in osteoarthritis initiation and development. Clearing the specific mechanism of MAPKs pathway in osteoarthritis will help the targeted treatment for osteoarthritis.

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