中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (30): 5569-5576.doi: 10.3969/j.issn.2095-4344.2012.30.013

• 骨与关节临床实践 clinical practice of the bone and joint • 上一篇    下一篇

骨靶向亲和性引经药防治原发性骨质疏松症

武密山1，武博文2，任立中3，王 茹1，白 霞1，韩红伟1，李 彬4，赵素芝5   

  1. 1河北医科大学中医学院方剂学教研室，河北省石家庄市 050091；
    2河北医科大学西山校区2011级临床医学专业，河北省石家庄市 050000；
    3河北医科大学第一医院骨科，河北省石家庄市 050031；
    4河北医科大学生物化学教研室，河北省石家庄市 050017；
    5石家庄市桥东区医院，河北省石家庄市 050041
  • 收稿日期:2012-01-05 修回日期:2012-02-12 出版日期:2012-07-22 发布日期:2012-07-22
  • 通讯作者: 赵素芝，副主任医师，石家庄市桥东区医院；河北省石家庄市 050041 okgood888@163.com
  • 作者简介:武密山☆，男，1966年生，河北省鹿泉市人，1998年河北医科大学毕业，博士，教授，硕士生导师，主要从事补肾中药治疗骨质疏松机制研究。 wumishan@163.com

Effect of bone targeted affinity medicinal guiding in preventing and treating primary osteoporosis

Wu Mi-shan1, Wu Bo-wen2, Ren Li-zhong3, Wang Ru1, Bai Xia1, Han Hong-wei1, Li Bin4, Zhao Su-zhi5   

  1. 1Department of Pharmacology of Traditional Chinese Medical Formulae, Traditional Chinese Medicine College of Hebei Medical University, Shijiazhuang 050091, Hebei Province, China;
    2Department of Clinical Medicine (Grade 2011), Western Hills Campus of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China;
    3Department of Orthopedics, the First Hospital of Hebei Medical University, Shijiazhuang 050031, Hebei Province, China;
    4Department of Biochemistry, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China;
    5Qiaodong District Hospital of Shijiazhuang, Shijiazhuang 050041, Hebei Province, China
  • Received:2012-01-05 Revised:2012-02-12 Online:2012-07-22 Published:2012-07-22
  • Contact: Zhao Su-zhi, Associate chief physician, Qiaodong District Hospital of Shijiazhuang, Shijiazhuang 050041, Hebei Province, China okgood888@163.com
  • About author:Wu Mi-shan☆, Doctor, Professor, Master’s supervisor, Department of Pharmacology of Traditional Chinese Medical Formulae, Traditional Chinese Medicine College of Hebei Medical University, Shijiazhuang 050091, Hebei Province, China wumishan@163.com

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372

被引次数

9

摘要：

背景：“肾主骨”符合骨代谢调节机制，依此“引经报使”和“骨靶向亲和性”理论研制的补肾复方在骨质疏松症虽取得较好效果，应用大、小药引子不同比例配伍补肾复方临床观察骨质疏松症指标，有望阐明大、小药引子两种争论的观点。
目的：通过大、小药引子不同配伍比例的补肾方药靶向给药治疗经络辨证的骨质疏松患者，观察引经药对不同经络病症是否存在主动靶向特异选择性差异？
方法：将180例经络辨证的骨质疏松患者随机分为6组。大剂量药引子肾经、肝经、脾经组分别口服牛膝 20 g，配伍抗骨松丹杞颗粒10 g/次，3次/d；小剂量药引子肾经、肝经、脾经组分别口服牛膝 10 g，配伍抗骨松丹杞颗粒10 g/次，3次/d。各组均以6个月为1个疗程，用药期间不进行其他抗骨质疏松治疗。比较6组患者的骨痛等症状与腰椎骨密度及血清钙、碱性磷酸酶、骨钙素、尿羟脯氨酸、尿钙、尿肌酐、雌二醇、睾酮等指标，评价综合疗效。
结果与结论：大药引子配伍抗骨松丹杞颗粒可有效治疗经络辨证属于肝、肾经的骨质疏松症，能明显提高腰椎骨密度，提高骨痛缓解率，未见相关不良反应。大、小药引子相比较，“大药引子”疗效更好。

关键词: 骨靶向亲和性, 原发性骨质疏松, 引经药, 骨密度, 骨代谢, 经络辨证

Abstract:

BACKGROUND: The theory of “kidney is in charge of the bones” is in line with the mechanism of bone metabolic regulation in modern medicine, the tonifying kidney prescriptions made according to the bone targeted affinity and medicinal guiding of cell signal transduction has effective action for osteoporosis, but further researches should focus on the action mechanism of the compatibility ratio of high dose and low dose guiding drugs at skeleton formation. It can clarify the two arguments about application of high dose and low dose guiding drugs by observing osteoporosis relevant specific indexes in clinic.
OBJECTIVE: To investigate the correlation between target-oriented administration and drug own selectivity target-tropism special guiding carrier structure by comparing the treatment effects of the channel tropism functions of prescription for kidney tonifying of the compatibility ratio of high dose and low dose guiding drugs on primary osteoporosis of the channel and collaterals according to diagnosis.
METHODS: The 180 patients with osteoporosis were randomly divided into six groups: high dose guiding drugs for kidney meridian group (HKG), low dose guiding drugs for kidney meridian group (LKG), high dose guiding drugs for liver meridian group (HLG), low dose guiding drugs for liver meridian group (LLG), high dose guiding drugs for spleen meridian group (HSG), low dose guiding drugs for spleen meridian group (LSG) with 30 cases in each group. Patients in HKG, HLG and HSG were given 20 g Achyranthes bidentata Bl versus 10 g Kang Gu Song Dan Qi instant granules every time respectively, three times daily for successive 6 months. Patients in LKG, LLG and LSG were given 20 g Achyranthes bidentata Bl versus 10 g Kang Gu Song Dan Qi instant granules every time, three times daily, six months as one course of treatment, and no other anti-osteoporosis treatment was performed during administration. The curative effect was evaluated by observing bone ache symptoms and changes in bone mineral density of lumbar vertebrae, serum calcium, alkaline phosphatase, bone gla protein, urinary hydroxyproline, urine calcium, urine creatinine, estradiol and testosterone.
RESULTS AND CONCLUSION: High dose guiding drugs versus Kang Gu Song Dan Qi instant granules could treat primary osteoporosis of the channel and collaterals according to diagnosis. It could obviously increase the bone mineral density of lumbar vertebrae and the alleviating rate of ostealgia, and without any related adverse effect. Prescription for tonifying kidney of the compatibility ratio of high dose and low dose guiding drugs has effects on treating the primary osteoporosis, and the effect of the former is better than the latter.

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