中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (27): 5103-5107.doi: 10.3969/j.issn.2095-4344.2012.27.031

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

缺血性脑损伤后内源性神经干细胞迁移机制及中医药的调节作用

苏晓慧1，2，孔祥英1，林 娜1   

  1. 1中国中医科学院中药研究所，北京市 100700；
    2承德医学院，河北省承德市 067000
  • 收稿日期:2011-12-07 修回日期:2012-02-23 出版日期:2012-07-01 发布日期:2013-11-01
  • 通讯作者: 孔祥英，博士，助理研究员，中国中医科学院中药研究所，北京市 100700 kongu0051@163.com
  • 作者简介:苏晓慧★，女，1984年生，河北省承德市人，满族，承德医学院在读硕士，主要从事中药药理研究。 sxh66159@163.com
  • 基金资助:

    国家自然科学基金面上项目(30873394)；中国中医科学院自主选题(ZZ2006105)

Mechanism underlying endogenous neural stem cells migration following ischemic brain damage and the regulatory effect of traditional Chinese medicine

Su Xiao-hui1,2, Kong Xiang-ying1, Lin Na1   

  1. 1Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;
    2Chengde Medical College, Chengde 067000, Hebei Province, China
  • Received:2011-12-07 Revised:2012-02-23 Online:2012-07-01 Published:2013-11-01
  • Contact: Kong Xiang-ying, M.D., Researcher assistant, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China kongu0051@163.com

PDF

365

被引次数

20

摘要：

背景：研究表明脑内的神经干细胞在多种因素的作用下迁移到损伤部位，填补和部分修复坏死的脑组织，可以使神经功能部分恢复。
目的：综述目前缺血性脑损伤后内源性神经干细胞迁移机制及中医药的调节作用。
方法：以“cerebral ischemia，endogenous neural stem cells，migration”为英文关键词，以“脑缺血、内源性神经干细胞、神经再生、迁移”为中文关键词，检索2000-01/2011-08 PubMed数据库，中国期刊全文数据库，中国博士学位论文全文数据库及中国优秀硕士学位论文全文数据库，纳入有关缺血性脑损伤后内源性神经干细胞迁移的机制及中医药调节作用的文献。
结果与结论：大量的研究证实脑损伤后神经干细胞向病灶处迁移。损伤后促进神经干细胞迁移的因子主要包括：趋化因子、生长因子、神经营养因子、炎性因子等。同时，很多研究也证实中医药在调节内源性神经干细胞迁移过程中发挥了重要作用。

关键词: 缺血性脑损伤, 神经干细胞, 迁移, 中药, 综述文献, 干细胞

Abstract:

BACKGROUND: Migration of endogenous neural stem cells (NSCs) caused by ischemic brain injury has been a spot light in neuroscience. After ischemic brain injury, neuron becomes swelling and necrotic due to ischemia and hypoxia. NSCs that migrated to the necrosis area driven by a variety of factors can repair the brain tissue and make neural function recovered partially.
OBJECTIVE: To review the mechanism underlying NSCs migration caused by ischemic brain injury and the regulatory effects of traditional Chinese medicine.
METHODS: A computer-based retrieval of PubMed Database, Chinese Journal Full-text Database, China Doctor Dissertations Full-text Database and China National Knowledge Infrastructure to search articles describing the mechanism underlying NSCs migration caused by ischemic brain injury and the regulatory effects of traditional Chinese medicine published from 2000 to 2011 using the key words “cerebral ischemia, endogenous neural stem cells, migration, traditional Chinese medicine”. The repetitive studies were excluded. The retrieved literatures contained original articles, thesis and reviews.
RESULTS AND CONCLUSION: A great number of articles have proven that NSCs migrate to the lesion site after brain injury. Factors such as cytokines, growth factors, chemotactic factors and inflammatory factors are involved in the migration of NSCs. Also, many studies have also confirmed that traditional Chinese medicine plays an important role in regulating the migration of endogenous NSCs.

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