中国组织工程研究 ›› 2019, Vol. 23 ›› Issue (35): 5727-5731.doi: 10.3969/j.issn.2095-4344.1943

• 组织构建循证医学 evidence-based medicine in tissue construction • 上一篇    下一篇

有氧运动干预老年轻度认知功能障碍的Meta分析

刘东祺1,李荣梅1,张美琪1,陈妍妍1,张海平2   

  1. (1沈阳医学院,辽宁省沈阳市  110034;2沈阳体育学院,辽宁省沈阳市  110102)
  • 收稿日期:2019-07-02 出版日期:2019-12-18 发布日期:2019-12-18
  • 通讯作者: 李荣梅,硕士,教授,硕士生导师,沈阳医学院,辽宁省沈阳市 110034
  • 作者简介:刘东祺,男,1990年生,汉族,沈阳医学院在读硕士,主要从事老年人轻度认知障碍的研究。
  • 基金资助:

    辽宁省科技厅项目(2018225012),项目负责人:李荣梅;辽宁省教育厅科学研究项目(L2016ST03),项目负责人:张海平

Meta-analysis of the effect of aerobic exercise on mild cognitive impairment in the elderly

Liu Dongqi1, Li Rongmei1, Zhang Meiqi1,Chen Yanyan1, Zhang Haiping2   

  1. (1Shenyang Medical College, Shenyang 110034, Liaoning Province, China; 2Shenyang Sport University, Shenyang 110102, Liaoning Province, China)
  • Received:2019-07-02 Online:2019-12-18 Published:2019-12-18
  • Contact: Li Rongmei, Master, Professor, Master’s supervisor, Shenyang Medical College, Shenyang 110034, Liaoning Province, China
  • About author:Liu Dongqi, Master candidate, Shenyang Medical College, Shenyang 110034, Liaoning Province, China
  • Supported by:

    the Project of Science and Technology Department of Liaoning Province, No. 2018225012 (to LRM); the Scientific Research Project of Education Department of Liaoning Province, No. L2016ST03 (to ZHP)

摘要:

文章快速阅读:

文题释义:

轻度认知障碍:也称轻度认知功能损害,是介于正常老龄化与痴呆之间的一个临床阶段,医记忆障碍为主要特点。文章研究的纳入标准为60岁以上患轻度认知障碍的老年人,均为随机对照试验,目的是探究有氧运动在轻度认知障碍老年患者中认知功能改善情况。
Meta分析:是对原始研究的二次综合分析与评价。随着循证医学的发展,Meta分析已被公认为客观评价和合成针对某一特定问题研究证据的最佳手段,被视为最高级的证据。而这证据正是循证医学的核心,基于随机对照试验的系统评价/Meta分析是当前公认的最高级别的证据。
摘要
背景
:既往研究显示运动可能改善老年性痴呆和轻度认知功能障碍患者的认知功能。
目的:通过Meta分析了解有氧运动对我国老年人轻度认知功能障碍的影响情况。
方法:制定检索策略和纳入排除标准,检索中国期刊全文数据库(China national knowledge infrastructure,CNKI)、中国生物医学文献数据库(China biology medicine disc,CBMdisc)、万方数据库、维普数据库(VIP database,VIP)、PubMed、EBSCOhost、Cochrane图书馆,检索有氧运动对老年轻度认知障碍的随机对照试验。进行Cochrane偏倚风险评估,对有效的信息进行选取录入,使用RevMan5.3统计软件进行Meta分析。
结果与结论:最终筛选后得到9篇文献,均为随机对照研究。Meta分析结果显示,有氧运动干预后试验组简易精神状态检查量表评分高于对照组[MD=1.51,95%CI(0.54,2.48),P < 0.01];有氧运动干预后试验组蒙特利尔认知评估量表评分高于对照组[MD=2.90,95%CI(1.92,3.88),P < 0.000 01];3个月有氧运动干预后试验组的认知情况评分高于对照组[SMD=0.77,95%CI(0.33,1.20),P=0.000 6];6个月有氧运动干预后试验组的认知情况评分高于对照组[SMD=0.73,95%CI(0.19,1.28),P=0.008];持续数月有氧运动干预后试验组的认知情况评分高于对照组[SMD=0.89,95%CI(0.60,1.18),P < 0.000 01]。提示在自身状况耐受情况下,长期坚持有氧运动能够改善老年人的认知状况,且此方法安全性高可行性强,更加易于在老年群体中开展。

关键词: 轻度认知障碍, Meta分析, 有氧运动, 老年人, 影响因素, 认知障碍, 运动干预, 体育锻炼

Abstract:

BACKGROUND: Preliminary study has shown that exercise can improve the cognitive function in senile dementia and patients with mild cognitive impairment.
OBJECTIVE: To understand the effect of aerobic exercise on mild cognitive impairment in elderly people in China by meta-analysis.
METHODS: The search strategies and inclusion and exclusion criteria were developed, and CNKI, CBMdisc, WanFang, VIP, PubMed, EBSCOhost and Cochrane library databases were searched to retrieve the randomized controlled trials concerning aerobic exercise in the elderly patients with mild cognitive impairment. Risk assessment of Cochrane bias was performed, valid information was selected and input, and meta-analysis was performed on RevMan 5.3 software.
RESULTS AND CONCLUSION: Finally, nine articles were obtained, all of which were randomized controlled studies. Meta-analysis results showed that the mini-mental state examination score in the trial group was higher than that in the control group after aerobic exercise intervention [MD=1.51, 95%CI (0.54, 2.48), P < 0.01]. The Montreal Cognitive Assessment score in the trial group was higher than that in the control group [MD=2.90, 95%CI (1.92, 3.88), P < 0.000 01]. After 3 months of aerobic exercise intervention, the cognitive score in the trial group was higher than that in the control group [SMD=0.77, 95%CI (0.33, 1.20), P=0.000 6]. After 6 months of aerobic exercise intervention, the cognitive score in the trial group was higher than that in the control group [SMD=0.73, 95%CI (0.19, 1.28), P=0.008]. After several months of aerobic exercise intervention, the cognitive score in the trial group was higher than that in the control group [SMD=0.89, 95%CI (0.60, 1.18), P < 0.000 01]. In summary, long-term exercise can improve the cognitive function in the elderly, and this method is safe and feasible, and is easy to carry out in the elderly.

Key words: mild cognitive impairment, meta-analysis, aerobic exercise, elderly, influencing factors, cognitive impairment, exercise intervention, physical exercise

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