中国组织工程研究

中国组织工程研究 ›› 2018, Vol. 22 ›› Issue (31): 5021-5026.doi: 10.3969/j.issn.2095-4344.0565

• 骨与关节综述 bone and joint review • 上一篇    下一篇

构建骨缺损植入材料非人灵长类动物模型的研究与进展

严 霞1，2，张亚楠1，2，孟增东2，3   

  1. 1昆明理工大学医学院，云南省昆明市 650500；2昆明理工大学附属医院骨科，云南省昆明市  650032；3云南省第一人民医院骨科，云南省昆明市  650032
  • 出版日期:2018-11-08 发布日期:2018-11-08
  • 通讯作者: 孟增东，博士，主任医师，教授，昆明理工大学附属医院骨科，云南省昆明市 650032；云南省第一人民医院骨科，云南省昆明市 650032
  • 作者简介:严霞，女，1994年生，汉族，四川省人，2016西华师范大学毕业，昆明理工大学医学院、昆明理工大学附属医院在读硕士，主要从事生物材料在非人灵长类动物体内的生物相容性及成骨活性研究。
  • 基金资助:

    国家自然科学基金项目(31860264)；云南省应用基础研究项目(2015FB094)

Research progress of non-human primate models for bone defect implant materials

Yan Xia1, 2, Zhang Ya-nan1, 2, Meng Zeng-dong2, 3   

  1. 1Medical School of Kunming University of Science and Technology, Kunming 650500, Yunnan Province, China; 2Department of Orthopedics, the Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan Province, China; 3Department of Orthopedics, The First People’s Hospital of Yunnan Province, Kunming 650032, Yunnan Province, China
  • Online:2018-11-08 Published:2018-11-08
  • Contact: Meng Zeng-dong, MD, Chief physician, Professor, Department of Orthopedics, the Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan Province, China; Department of Orthopedics, The First People’s Hospital of Yunnan Province, Kunming 650032, Yunnan Province, China
  • About author:Yan Xia, Master candidate, Medical School of Kunming University of Science and Technology, Kunming 650500, Yunnan Province, China; Department of Orthopedics, the Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 31860264; the Basic Applied Research Project in Yunnan Province, No. 2015FB094

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摘要：

文章快速阅读：

 
 
文题释义：
骨缺损及骨缺损植入材料：骨缺损指由于创伤、肿瘤、感染、先天畸形等引起的骨结构不完整，当骨缺损过大超过能自愈的临界值时则很难自行完全愈合。骨缺损植入材料是在出现无法自愈的骨缺损问题时植入患处起修复、填充、固定和支撑等作用的医用材料。
疾病动物模型：指具有人类疾病模拟表现的动物。建立疾病动物模型作为科学研究的基本方法之一，在探索疾病发病机制及药物筛选等方面有着极其重要的作用，并且是新药物应用于临床前必经的实验环节，其中非人灵长类动物因具有高度的“类人性”，成为了基础研究和临床应用之间的纽带。
 
摘要
背景：近年来，骨缺损疾病的发生率不断升高，自体骨和同种异体骨用于治疗骨缺损又受到各方面的限制，研制并筛选出能有效解决这个问题的骨缺损修复材料愈发受到关注。
目的：综述近年来各类骨缺损植入材料修复非人灵长类动物骨缺损疾病的研究进展。
方法：检索PubMed数据库及CNKI中国期刊全文数据库等数据库收录的有关构建骨缺损植入材料动物模型的实验研究及进展情况的文章。英文检索词为“bone defect，implant material，repair，non-human primate，animal model”；中文检索词为“骨缺损、植入材料、修复、非人灵长类、动物模型”。纳入与骨缺损植入材料及其动物模型的实验研究及进展情况相关性高的文献共计40篇。
结果与结论：对近年来骨缺损植入材料的非人灵长类动物模型的研究现状进行调查，发现近年来骨缺损植入材料的非人灵长类动物模型的相关研究较少，而且文章之间关联性较低，但研究结果良好。单一成分骨缺损植入材料已在临床上得到了广泛的应用，但几种成分复合而成的骨缺损植入材料却鲜有报道应用于临床治疗，主要研究还停留在动物实验阶段。其中研究复合有骨生长因子如骨形态发生蛋白2、转化生长因子β等或种子细胞(如骨髓间充质干细胞及牙髓干细胞等)的复合材料较多。

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程
ORCID: 0000-0001-8288-9023(严霞)

关键词: 骨缺损, 植入材料, 非人灵长类动物模型, 自体骨, 同种异体骨, 人工骨, 骨形态发生蛋白2, 转化生长因子β, 骨髓间充质干细胞, 牙髓细胞, 组织工程

Abstract:

BACKGROUND: Incidence of bone defects is increasing, and autologous bone and allogeneic bone are subjected to various restrictions in the treatment of bone defects. Thereafter, the development and screening of bone defect repair materials that can effectively solve above problem have received attention.

OBJECTIVE: To summarize the current research status of bone defect implant materials repairing bone defects in non-human primate models.
METHODS: The articles addressing the experimental research and research progress of animal models of bone defect implant materials were retrieved in PubMed and CNKI databases. The keywords were “bone defect, implant material, repair, non-human primate, animal model” in English and Chinese, respectively. A total of 40 articles were included, and highly correlated with the experimental research and progress of bone defect implant materials and animal models.
RESULTS AND CONCLUSION: Through investigating the current research status of non-human primate models of bone defect implant materials, we can find that the studies on non-human primate models of bone defect implant materials are few. The correlation between the articles is low, but the research results are good. Bone defect implant materials with single component have been extensively applied in clinical practice. However, bone defect implant materials with composite components are little reported, and its research is mainly on the stage of animal experiments. Among them, most studies focus on the composite materials which combine bone growth factors (such as bone morphogenetic protein-2 and transforming growth factor-β) or seed cells (such as bone marrow stromal cells and dental pulp stromal cells).

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

Key words: Bone Morphogenetic Proteins, Models, Animal, Biocompatible Materials

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