中国组织工程研究 ›› 2018, Vol. 22 ›› Issue (32): 5104-5109.doi: 10.3969/j.issn.2095-4344.0545

• 骨组织构建 bone tissue construction • 上一篇    下一篇

骨质疏松症与SD大鼠膝骨性关节炎的发病

郑兆宽,赵洪普,吕玉明,曾  敬,龚翼星,黄健威   

  1. 广州医科大学附属第三医院,广东省广州市  510150
  • 收稿日期:2018-04-28 出版日期:2018-11-18 发布日期:2018-11-18
  • 通讯作者: 赵洪普,广州医科大学附属第三医院,广东省广州市 510150
  • 作者简介:郑兆宽,研究方向为骨质疏松症、骨性关节炎。
  • 基金资助:

    广州市荔湾区科技和信息化局专项基金资助项目(20131215073-1)

Relationship between osteoporosis and incidence of knee osteoarthritis in Sprague-Dawley rats

Zheng Zhao-kuan, Zhao Hong-pu, Lü Yu-ming, Zeng Jing, Gong Yi-xing, Huang Jian-wei   

  1. the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, Guangdong Province, China
  • Received:2018-04-28 Online:2018-11-18 Published:2018-11-18
  • Contact: Zhao Hong-pu, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, Guangdong Province, China
  • About author:Zheng Zhao-kuan, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, Guangdong Province, China
  • Supported by:

    a grant from Science, Technology and Information Bureau of Guangzhou Liwan District, No. 20131215073-1

摘要:

文章快速阅读:

文题释义:
骨质疏松:是以骨量减少,骨组织细微结构破坏导致骨骼脆性增加和骨折危险性增加为特征的一种系统性、全身性骨骼疾病。其是与人体衰老密切联系的退行性疾病,发生率随年龄增长而逐渐。骨质疏松的严重后果是椎体压缩性骨折,预防性的早期规范干预至关重要。
骨密度测定:方法有很多种,目前最常用且国内外公认的是双能X射线吸收法。双能X射线吸收法测得的数值,可作为骨质疏松诊断的金标准。骨密度检查的其他方法还有各种单光子、单能X射线、定量计算机断层照相等,可以根据具体情况与条件用于骨质疏松的诊断。医院最常采用的部位是腰椎和髋部,这2个部位也是骨质疏松的好发部位。
摘要
背景
:骨性关节炎患者的骨质疏松发生率明显高于健康人群,表明在导致骨性关节炎成的诸多因素中,也存在着导致骨质疏松的影响因素。
目的:明确骨质疏松对膝骨性关节炎发病产生影响。
方法:将28只大鼠随机等分为骨性关节炎组和骨质疏松+骨性关节炎组,骨质疏松+骨性关节炎组大鼠行卵巢摘除建立骨质疏松模型,2组大鼠在骨质疏松模型建立后1个月,左膝关节内注射木瓜蛋白酶溶液诱导骨性关节炎模型,同时将2组大鼠右侧膝关节分别作为对照组和骨质疏松组。
结果与结论:与右侧膝关节对比,2组大鼠左膝侧关节骨赘增生,且骨质疏松+骨性关节炎组关节炎症状更为严重。骨质疏松+骨性关节炎组大鼠Mankin评分高于骨性关节炎组,且L1-4骨密度低于骨性关节炎组。说明骨质疏松症在一定程度上能促进骨性关节炎的发展。

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程
ORCID: 0000-0003-4388-1242(郑兆宽)

关键词: 骨质疏松, 骨性关节炎, 骨密度, 木瓜蛋白酶, 复合动物模型, 动物实验, Mankin评分, 组织构建

Abstract:

BACKGROUND: Incidence of osteoporosis in patients with osteoarthritis is significantly higher than that of 
healthy people, indicating that there are factors leading to osteoporosis and osteoarthritis.
OBJECTIVE: To determine the effect of osteoporosis on the pathogenesis of osteoarthritis.
METHODS: Twenty-eight rats were equivalently randomized into osteoarthritis and osteoporosis plus osteoarthritis (ovariectomy to induce osteoporosis) groups. One month after modeling, papain was injected into the left knee joint of each group to induce osteoarthritis, and the right knee joint in both groups served as the controls.
RESULTS AND CONCLUSION: Compared with the right knee joint, osteophyte hyperplasia was observed at the left knee joint in both groups, and arthritis was more severe in the osteoporosis plus osteoarthritis group than in the osteoarthritis group. The Mankin scores in the osteoporosis plus osteoarthritis group were higher than those in the osteoarthritis group. The bone mineral density of L1-4 in the osteoporosis plus osteoarthritis group was lower than that in the osteoarthritis group. To conclude, osteoporosis can promote the development of osteoarthritis to some extent.

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程

Key words: Osteoarthritis, Osteoporosis, Tissue Engineering

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