中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (24): 4530-4534.doi: 10.3969/j.issn.1673-8225.2012.24.033

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

核转录因子Nrf2最新研究进展

李雪丽，唐 云，许雪珠   

  1. 大连大学附属中山医院皮肤科，辽宁省大连市 116001
  • 收稿日期:2011-10-28 修回日期:2011-11-21 出版日期:2012-06-10 发布日期:2013-11-05
  • 通讯作者: 许雪珠，博士，大连大学附属中山医院皮肤科，辽宁省大连市 116001 xuxuezhu@hotmail.com
  • 作者简介:李雪丽★，女，1987年生，广西壮族自治区桂林市人，汉族，大连大学在读硕士，主要从事皮肤外科方面的研究。 499812767@qq.com
  • 基金资助:

    国家教育部回国人员科研启动基金(第40批)

Latest research progress of nuclear transcription factor Nrf2

Li Xue-li, Tang Yun, Xu Xue-zhu   

  1. Department of Dermatology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, Liaoning Province, China
  • Received:2011-10-28 Revised:2011-11-21 Online:2012-06-10 Published:2013-11-05
  • Contact: Xu Xue-zhu, Doctor, Department of Dermatology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, Liaoning Province, China xuxuezhu@hotmail.com
  • About author:Li Xue-li★, Studying for master?s degree, Department of Dermatology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, Liaoning Province, China 499812767@qq.com

PDF

1765

被引次数

30

摘要：

背景：核转录因子Nrf2属于CNC亮氨酸拉链转录激活因子家族，与抗氧化反应、抗炎反应及细胞保护作用等有关。
目的：总结核转录因子Nrf2的功能，与肿瘤的转归和抗肿瘤药物性，以及与全身各个系统其他疾病的相关性。
方法：应用计算机检索1990-01/2011-07PubMed数据库，检索词为“Nrf2，Keap1”。选择核转录因子Nrf2的基础研究与临床应用方面的文献，排除陈旧及重复试验文章，最终纳入50篇符合标准的文献。
结果与结论：Nrf2不仅与抗氧化应激有关，而且与肿瘤的发生发展及转移、抗肿瘤药物性相关，同时发现除与氧化应激性疾病有关，还与全身各个系统其他疾病的发生及中毒有关。Nrf2诱导物有可能成为有潜力的基因靶向治疗药物。

关键词: 核转录因子, Nrf2, Keap1, 氧化应激, 细胞保护作用

Abstract:

BACKGROUND: Nuclear transcription factor Nrf2 belongs to the activated transcription factor family of leucine-zipper. It is related to antioxidant response, anti-inflammatory response and cytoprotection.
OBJECTIVE: To summarize the function of nuclear transcription factor Nrf2 and its relationship with tumor prognosis, antineoplastic property and other diseases of the body system.
METHODS: An online search of PubMed database was performed for articles published between January 1990 and July 2011 with the key word of “Nrf2, Keap1” in English. Articles related to basic research and clinical practice of nuclear transcription factor Nrf2 was included. Obsolete or repetitive articles were excluded. A total of 50 articles were retained in the end.
RESULTS AND CONCLUSION: Nrf2 is not only related to anti-oxidative stress, but to the occurrence, progression and metastasis of tumors. Meanwhile, it is found that Nrf2 is related to many diseases and intoxication in the body system other than oxidative stress-induced disease. Nrf2 inducers may become a potential drug for gene-targeted therapy.

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