中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (17): 3213-3217.doi: 10.3969/j.issn.1673-8225.2012.17.039

• 骨与关节综述 bone and joint review • 上一篇    下一篇

腰椎Modic改变中炎性细胞因子的效应★

姜世峰，申才良   

  1. 安徽医科大学第一附属医院骨科，安徽省合肥市 230022
  • 收稿日期:2011-10-02 修回日期:2012-02-20 出版日期:2012-04-22 发布日期:2012-04-22
  • 通讯作者: 申才良，教授，硕士生导师，安徽医科大学第一附属医院骨科，安徽省合肥市 230022 shengcailiang1616@yahoo.com
  • 作者简介:姜世峰★，男，1986年生，安徽省凤阳县人，汉族，2009年安徽医科大学毕业，硕士，主从事脊柱外科的研究。 Jiangshifeng1986@163.com

Effect of inflammatory cytokines in lumbar Modic changes

Jiang Shi-feng, Shen Cai-liang   

  1. Department of Orthopedics, the First Affiliated Hospital of Anhui Medical University, Hefei  230022, Anhui Province, China
  • Received:2011-10-02 Revised:2012-02-20 Online:2012-04-22 Published:2012-04-22
  • Contact: Shen Cai-liang, Professor, Master’s supervisor, Department of Orthopedics, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China shengcailiang1616@yahoo.com
  • About author:Jiang Shi-feng★, Master, Department of Orthopedics, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China Jiangshifeng1986@163.com

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摘要：

背景：椎间盘退变和终板异常可能是椎间盘源性下腰痛的病因，大量文献报道，炎性细胞因子在腰椎退变性疾病中发挥着极其重要的作用。
目的：综述炎性细胞因子在腰椎Modic改变中的研究进展。
方法：应用计算机检索2010-01/2011-09中国生物医学文献服务系统相关文章，检索词为“modic改变，椎体终板”，并限定文章语言种类为中文。同时计算机检索PubMed数据库相关文章，检索词为“modic，vertebral endplate”，并限定文章语言种类为English。共检索到文献48篇，最终纳入符合标准的文献30篇。
结果与结论：腰椎Modic改变是指腰椎终板及终板下骨质在MRI上的异常信号改变，其病变机制目前不是十分清楚。有文献证实退变椎间盘髓核内部炎性物质(肿瘤坏死因子/神经标志物蛋白质基因产物/白细胞介素)的产生，通过终板扩散可导致终板局部炎症，引发终板退变。近年来随着分子生物学和分子免疫学的迅速发展以及对细胞因子和炎症递质研究的深入，细胞因子和炎症递质在腰椎终板退变中的作用越来越受到重视，目前对于细胞因子和炎性递质在腰椎Modic改变中的作用正在进一步的深入中。

关键词: Modic改变, 磁共振, 腰椎, 椎体终板, 综述文献

Abstract:

BACKGROUND: Intervertebral disc degeneration and endplate abnormalities may be the cause of discogenic low back pain, extensive literatures have reported that inflammatory cytokines play an important role in lumbar degenerative diseases.  
OBJECTIVE: To summary the research progress of inflammatory cytokines in the lumbar Modic changes.
METHODS: The computers were used to retrieve database-related articles on Chinese biomedical literature service system from January 2010 to September 2011 with the key words of "Modic changes, Vertebral endplate” in Chinese. A computer-based retrieve was preformed on the PubMed database for the relate articles with the key words of “Modic changes, Vertebral endplate” in English. A total of 48 articles were retrieved, and finally, 30 articles were included according to the inclusion criteria.
RESULTS AND CONCLUSION: The lumbar Modic change refers to the abnormal signal on MRI of the lumbar endplate and endplate under bone changes, and the lesion mechanism is not very clear. Literatures have confirmed that the nucleus pulposus degeneration of the internal generation of inflammatory substances (tumor necrosis factor/neural marker protein gene product/leukocyte interleukin) can lead to local inflammation through the endplate diffusion and finally cause the endplate degeneration. In recent years, with the rapid development of molecular biology and molecular immunology, as well as in-depth study of cytokines and inflammatory mediators, the effect of cytokines and inflammatory mediators in lumbar endplate degeneration attracted more and more attention, the current researches on the effect of cytokines and inflammatory mediators in the lumbar Modic changes are being further in-depth.

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