中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (8): 1479-1482.doi: 10.3969/j.issn.1673-8225.2012.08.033

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

不同敷料修复创面的实验研究及临床应用评价★

首家保，陈  彬，芦  慎，王彤华，杨小辉   

  1. 广西医科大学第四附属医院，柳州市工人医院烧伤整形外科，广西壮族自治区柳州市  545005
  • 收稿日期:2011-11-12 修回日期:2012-01-18 出版日期:2012-02-19 发布日期:2012-02-19
  • 通讯作者: 陈彬，博士，广西医科大学第四附属医院，柳州市工人医院烧伤整形外科，广西壮族自治区柳州市 545005 dprs2008@ yahoo.com.cn
  • 作者简介:首家保★，男，1968年生，广西壮族自治区富川县人，瑶族，2003年广西医科大学毕业，硕士，研究生导师，主要从事难愈性创面修复的研究。 shoujiabao208@sina.com

Experimental study and clinical evaluation of different dressings in wound repair

Shou Jia-bao, Chen Bin, Lu Shen, Wang Tong-hua, Yang Xiao-hui   

  1. Department of Burn and Plastic Surgery, Liuzhou Worker’s Hospital, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou  545005, Guangxi Zhuang Autonomous Region, China
  • Received:2011-11-12 Revised:2012-01-18 Online:2012-02-19 Published:2012-02-19
  • Contact: Chen Bin, Doctor, Department of Burn and Plastic Surgery, Liuzhou Worker’s Hospital, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, Guangxi Zhuang Autonomous Region, China dprs2008@ yahoo.com.cn
  • About author:Shou Jia-bao★, Master, Master’s supervisor, Department of Burn and Plastic Surgery, Liuzhou Worker’s Hospital, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, Guangxi Zhuang Autonomous Region, China shoujiabao208@ sina.com

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摘要：

背景：各种材料以多种形式制成的创面敷料近年来发展迅速，复合应用或是制成凝胶、药膜的形式是目前研究和应用的热点。
目的：评价不同敷料在创面的实验研究或者临床应用。
方法：以 “敷料；创面；实验；应用”为关键词，对维普数据库2002-01/2011-10的相关文章进行计算机检索，纳入与敷料和创面相关的随机对照实验类文章，排除重复研究或Meta分析类文章，对22篇文献研究的资料结果进行提取、分析。
结果与结论：纳米银、聚维酮碘、壳聚糖、康复新等是用于实验动物创面的主要材料，分别与中空活性炭纤维、明胶海绵复合或是制成原位凝胶、药膜形式的材料，能最大程度地发挥抗感染、促进创面愈合的作用。壳聚糖、纳米银或者银离子、猪胶原纤维、生物光素、液超妥藻酸盐、痊愈妥等材料可用于临床患者创面，多是以复合或是制成水凝胶等形式，有利于发挥各自性能，更好地促进不同创面愈合。

关键词: 敷料, 壳聚糖, 炭纤维, 明胶海绵, 创面, 实验, 应用

Abstract:

BACKGROUND: In recent years, wound dressings made of different materials in various forms develop rapidly; composite application form, gel form and drug-membrane form are the current hot spots of research and application.
OBJECTIVE: To evaluate the experimental study and clinical application of different wound dressings.
METHODS: A computer-based online search of VIP database was performed for relevant articles published between January 2002 and October 2011, with the key words of “dressing”, “wound”, “experiment” and “application”. Randomized controlled studies relevant to dressings and wounds were included; repetitive studies and Meta analysis were excluded. The analysis was based on 22 documents.
RESULTS AND CONCLUSION: Nano-silver, povidone iodine, chitosan and Kangfuxin are main materials used for wound repair in experimental animals; the anti-infection effect and wound healing promotion are the maximum when the materials are composited with hollow activated carbon fibers and gelatin sponge respectively or made into in situ gel form or drug-membrane form. Chitosan, nano-silver, silver ion, pig collagen fibers, bio-optical elements, Algisite M Calcium Alginate, Allevyn and other materials in composite form or hydrogel form are used for wound repair in clinic; these forms will help their performance, and better promote the wound healing.

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