中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (7): 1327-1330.doi: 10.3969/j.issn.1673-8225.2012.07.044

• 组织构建临床实践 clinical practice in tissue construction • 上一篇    

新疆维吾尔族和哈萨克族健康人群转化生长因子β1T869C基因多态性与血管功能的相关性*★

贾冬雨，徐新娟，梁晓慧，张俊仕，孙理华   

  1. 新疆医科大学第一附属医院心脏中心高血压科，新疆维吾尔自治区乌鲁木齐市  830054
  • 收稿日期:2011-11-09 修回日期:2011-12-09 出版日期:2012-02-12 发布日期:2012-02-12
  • 通讯作者: 徐新娟，博士，主任医师，博士生导师，新疆医科大学第一附属医院心脏中心高血压科，新疆维吾尔自治区乌鲁木齐市 830054 zcxu2002@ medmail.com.cn
  • 作者简介:贾冬雨★，男，1983年生，新疆医科大学在读硕士，主治医师，主要从事高血压基础与临床及血管衰老的研究。 jdy799_1228@163.com
  • 基金资助:

    国家自然科学基金项目(30860296)。

Gene polymorphism of transforming growth factor-beta 1 T869C in healthy Uygur and Kazakh people of Xinjiang and its correlation with vascular function 

Jia Dong-yu, Xu Xin-juan, Liang Xiao-hui, Zhang Jun-shi, Sun Li-hua   

  1. Department of Hypertension, Heart Center, the First Teaching Hospital of Xinjiang Medical University, Urumqi  830054, Xinjiang Uygur Autonomous Region, China
  • Received:2011-11-09 Revised:2011-12-09 Online:2012-02-12 Published:2012-02-12
  • Contact: Xu Xin-juan, Doctor, Chief physician, Doctoral supervisor, Department of Hypertension, Heart Center, the First Teaching Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China zcxu2002@medmail.com.cn
  • About author:Jia Dong-yu★, Studying for master’s degree, Attending physician, Department of Hypertension, Heart Center, the First Teaching Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China jdy799_1228@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30860296*

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摘要：

背景：转化生长因子β1 (transforming growth factor-β1, TGF-β1)T869C基因多态性可能与血管功能遗传易感性相关，并且具有民族差异性。
目的：探讨新疆地区哈、维两民族TGF-β1T869C基因多态性的分布及中心动脉压反射波增强指数的差异。
方法：纳入新疆地区健康人群1 181人，其中维吾尔族589名、哈萨克族592名，应用PCR-RFLP检测受试者TGF-β1T869C多态性的分布情况，同时对其中心动脉压反射波增强指数进行检测，并应用多因素非条件logistic回归分析影响中心动脉压反射波增强指数升高的主要危险因素。
结果与结论：PCR-RFLP结果显示，新疆地区维吾尔族TGF-β1T869C位点基因型频率：TT型22.1%、TC型49.2%、TC型28.7%；等位基因频率：T等位基因46.7%，C等位基因53.3%。哈萨克族TGF-β1T869C位点基因型频率：TT型11.3%、TC型47.6%、CC型41.0%；等位基因频率：T等位基因35.1%，C等位基因64.9%。经比较，两民族TGF-β1T869C位点基因型及等位基因频率间差异均有显著性意义(P < 0.01)。对中心动脉压反射波增强指数检测发现其随年龄增长而递增，同时哈萨克族显著高于维吾尔族同年龄段并高于维族老年组(P < 0.01)。多因素非条件logistic回归分析显示，哈萨克族人群C等位基因个体发生中心动脉压反射波增强指数升高的风险高于其他因素。说明在新疆地区，TGF-β1T869C多态性分布存在民族差异，其可能影响中心动脉压反射波增强指数，并与哈萨克族血管硬化及衰老有关。

关键词: 维吾尔族, 哈萨克族, 转化生子因子&beta, 1, 基因多态性, 血管功能

Abstract:

BACKGROUND: Gene polymorphism of transforming growth factor β1 (TGF-β1) T869C may be related to the genetic susceptibility of vascular functions; and there is ethnic otherness between nationalities.
OBJECTIVE: To investigate the distribution of TGF-β1 T869C gene polymorphism and the difference between the augmentation indexes of central aortic pressure wave reflections in the Kazakh and Uygur people from Xinjiang.
METHODS: A total of 1 181 healthy people from Xinjiang region were involved, including 589 Uygur people and 592 Kazakh people. TGF-β1 T869C polymorphism distribution of the subjects were detected using PCR-RFLP; meanwhile the augmentation indexes of the corresponding central aortic pressure wave reflections were detected. Multiple-factor non-conditional logistic regression analysis was used to analyze the main risk factors which affect the augmentation indexes of central aortic pressure wave reflections.
RESULTS AND CONCLUSION: PCR-RFLP results showed that the genotype frequencies of TGF-β1 T869C site in Uygur people of Xinjiang were as follows: TT type 22.1%, TC type 49.2% and CC type 28.7%. Allele frequencies were as follows: T allele 46.7%, C allele 53.3%. The genotype frequencies of TGF-β1 T869C site in Kazakh people of Xinjiang were as follows: TT type 11.3%, TC type 47.6% and CC type 41%. Allele frequencies were as follows: T allele 35.1%, C allele 64.9%. There were significant differences between the genotypes of TGF-β1 T869C site and the allele frequencies of the two nationalities (P < 0.01). The augmentation indexes of central aortic pressure wave reflections increased with the growth of age; while the augmentation indexes of central aortic pressure wave reflections in the Kazakhs people were significantly higher than that in the Uygur people of the same age or in the older Uygur group (P < 0.01). Multiple-factor non-conditional logistic regression analysis showed that the risk of increased augmentation indexes of central aortic pressure wave reflections in the Kazakhs individuals who carrying C allele was higher than the other factors. These findings indicate that there is ethnic otherness between the distribution of TGF-β1 T869C gene polymorphism in Xinjiang, which may affect the augmentation indexes of central aortic pressure wave reflections, and is related with the vascular sclerosis and aging in the Kazakh people.
 

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