中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (47): 8907-8910.doi: 10.3969/j.issn.1673-8225.2011.47.042

• 生物材料临床实践 clinical practice of biomaterials • 上一篇    下一篇

肺癌患者生物材料相关感染与外周血转化生长因子β1水平的关系

雷玉洁1，黄云超1，杨  丽2，郭凤丽2，赵光强1，徐玉善3，陈小波1，杨凯云1   

  1. 昆明医学院第三附属医院(云南省肿瘤医院)，1胸心外科，2检验科，云南省昆明市 650118；3昆明医学院第一附属医院内分泌与代谢病科，云南省昆明市  650032
  • 收稿日期:2011-08-04 修回日期:2011-08-31 出版日期:2011-11-19 发布日期:2011-11-19
  • 通讯作者: 黄云超，教授，博士生导师，昆明医学院第三附属医院胸心外科，云南省昆明市 650118
  • 作者简介:雷玉洁☆，女，1977年生，云南省丽江市人，汉族，昆明医学院在读博士，讲师，主要从事胸心外科生物材料相关研究。
  • 基金资助:

    国家自然科学基金项目(30872555)；云南省科技厅社会发展科技计划应用基础研究项目(2009ZC116M)。

Relationship of biomaterials related infections and transforming growth factor levels in the peripheral blood of lung cancer patients

Lei Yu-jie1, Huang Yun-chao1, Yang Li2, Guo Feng-li2, Zhao Guang-qiang1, Xu Yu-shan3, Chen Xiao-bo1, Yang Kai-yun1   

  1. 1Department of Cardiothoracic Surgery, 2Clinical Laboratory, Third Affiliated Hospital of Kunming Medical University, Kunming  650118, Yunnan Province, China; 3Department of Endocrinology, First Affiliated Hospital of Kunming Medical University, Kunming  650031, Yunnan Province, China
  • Received:2011-08-04 Revised:2011-08-31 Online:2011-11-19 Published:2011-11-19
  • Contact: Huang Yun-chao, Professor, Doctoral supervisor, Department of Cardiothoracic Surgery, Third Affiliated Hospital of Kunming Medical University, Kunming 650118, Yunnan Province, China
  • About author:Lei Yu-jie☆, Studying for doctorate, Lecturer, Department of Cardiothoracic Surgery, Third Affiliated Hospital of Kunming Medical University, Kunming 650118, Yunnan Province, China huangych2001@ yahoo.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30872555*; the Applied Basic Research Program of Social Developmental Science Plan of Yunnan Science and Technology Bureau, No. 2009ZC116M*

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摘要：

背景：肺癌患者永久或暂时植入生物材料后可能发生以生物材料为中心的感染。
目的：分析肺癌患者以生物材料为中心感染与外周血转化生长因子β1之间的关系。
方法：纳入248例体内留置血管内插管>7 d的肺癌患者，定量法行插管细菌学培养和配对血液培养，阳性者用API细菌鉴定系统进行种属鉴定，同时用酶联免疫吸附法检测患者与75名健康志愿者外周血转化生长因子β1水平。
结果与结论：以生物材料为中心感染阳性者82例，以生物材料为中心感染阴性者166例，其中确诊为插管相关性血流感染13例。检出革兰阳性菌48株，革兰阴性杆菌24株，真菌10株。以生物材料为中心感染阳性组外周血转化生长因子β1水平较阴性组高  (P < 0.05)；以生物材料为中心感染阴性组外周血转化生长因子β1较正常组高(P < 0.05)。说明医源性感染导致肺癌患者并发体内以生物材料为中心感染发生的病原菌种属多样化，以革兰阳性菌多见；检测肺癌患者转化生长因子β1因子对早期预防以生物材料为中心感染有积极意义。

关键词: 肺癌, 以生物材料为中心感染, 生物材料, 转化生长因子&beta, 1, 革兰阳性菌

Abstract:

BACKGROUND: Permanent or transient implantation of biomaterials can result in biomaterials-centered infections (BCI) in lung cancer patients.
OBJECTIVE: To investigate the relationship between BCI and peripheral blood transforming growth factor β1 (TGF-β1) in patients with lung cancer.
METHODS: A total of 248 lung cancer patients undergoing in vivo intravascular catheter indwelling > 7 days were included. Quantitative method was used for intubation, bacteriological culture and paired blood culture, and API Staph strips were adopted for positive patients. While enzyme-linked immunosorbent assay was used to detect TGF-β1 levels in the peripheral blood of patients with lung cancer and 75 healthy volunteers as normal controls.
RESULTS AND CONCLUSION: Among the 248 patients, there were 82 BCI-positive cases, and 166 BCI-negative cases. Thirteen patients were confirmed to have catheter-related bloodstream infection. There were 48 Gram-positive bacteria, 24 Gram-negative bacilli, and 10 fungal. The levels of TGF-β1 were higher in BCI-positive patients than BCI-negative patients (P < 0.05); the levels of TGF-β1 in the BCI-negative group were higher than those in the normal control group (P < 0.05). For lung cancer patients with nosocomial infection induced BCI, there are various species of pathogenic bacteria, and Gram-positive bacteria are more common. To detect TGF-β1 levels in patients with lung cancer is of significance for early prevention of BCI.

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