中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (47): 8813-8816.doi: 10.3969/j.issn.1673-8225.2011.47.018

• 材料生物相容性 material biocompatibility • 上一篇    下一篇

负压吸附式止血敷贴的制备及其生物相容性

李明洋，黄赤兵，范明齐，冯嘉瑜，张嘉希，高  渝，陈益荣   

  1. 解放军第三军医大学新桥医院泌尿外二科，重庆市   400037
  • 收稿日期:2011-05-01 修回日期:2011-09-26 出版日期:2011-11-19 发布日期:2011-11-19
  • 通讯作者: 黄赤兵，博士，主任医师，解放军第三军医大学新桥医院泌尿外二科，重庆市 400037 huangchibing@medmail.com.cn
  • 作者简介:李明洋★，男，1983年生，重庆市潼南县人，汉族，2006年重庆医科大学毕业，硕士，主要从事止血材料及泌尿系肿瘤方面的研究。 mingyang6@hotmail.com
  • 基金资助:

    重庆市攻关课题(csci2007AC5046)，课题名称：吸附式止血敷贴关键部件的研制。

Preparation and biocompatibility of negative pressure adsorption hemostasis application

Li Ming-yang, Huang Chi-bing, Fan Ming-qi, Feng Jia-yu, Zhang Jia-xi, Gao Yu, Chen Yi-rong   

  1. Second Department of Urinary Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing  400037, China
  • Received:2011-05-01 Revised:2011-09-26 Online:2011-11-19 Published:2011-11-19
  • Contact: Huang Chi-bing, Doctor, Chief physician, Second Department of Urinary Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China huangchibing@ medmail.com.cn
  • About author:Li Ming-yang★, Master, Second Department of Urinary Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China mingyang6@hotmail.com
  • Supported by:

    the Tackle Key Project of Chongqing City, No. csci2007AC5046*

PDF

314

被引次数

5

摘要：

背景：部分止血材料存在有毒性及价格昂贵的缺陷。
目的：观察负压吸附式止血敷贴在动物体内的生物相容性。
方法：健康家猪6只在肝及肾划出长约1 cm，深约0.5 cm的条形切口，用负压吸附式止血敷贴覆盖。移植前观察检测血常规、肝肾功能及体液免疫学指标；移植后第14天观察再次检测血常规、肝肾功能及体液免疫学指标，并观察局部组织形态学变化。
结果与结论：植入前后血生化和免疫学等指标差异无显著性意义(P > 0.05)，肝肾组织切片显示无明显炎症反应，未见明显纤维细胞包膜。动物体内实验提示，负压吸附式止血敷贴无毒性、无排斥反应、无免疫反应、无过敏反应，具有良好的生物相容性。

关键词: 止血敷贴, 负压吸附, 多孔止血淀粉, 生物相容性, 不良反应

Abstract:

BACKGROUND: Some hemostatic materials applied at present have many shortages, such as toxicity and high cost.
OBJECTIVE: To study the biocompatibility of negative pressure adsorption hemostasis application in animals.
METHODS: A strip-shaped incision was created in the liver and kidney, 1 cm in length and 0.5 cm in depth. Negative pressure adsorption hemostasis application was used on the wound area of six healthy pigs. General state of the healthy pigs was observed before and after the operation. Blood routine examination, liver and kidney function, body fluid immunology before and 14 days after the operation were detected. Histopathological changes at 14 days were observed.
RESULTS AND CONCLUSION: There were no significant differences in blood biochemistry and immunology between the two groups (P > 0.05) and the histopathological results did not show any inflammatory reaction in incisions of liver and kidney tissues. There was no inflammation or fibrous tissue envelope. Negative pressure adsorption hemostasis application has good biocompatibility without any toxicity, reject reaction, immunological reaction and anaphylactic response in animals.

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