中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (45): 8547-8550.doi: 10.3969/j.issn.1673-8225.2011.45.042

• 干细胞临床实践 clinical practice of stem cells • 上一篇    

粒细胞集落刺激因子动员外周血干细胞富集致肺损伤1例

施  兵，刘丽辉，叶丽萍   

  1. 解放军第309医院血液科，北京市  100091
  • 收稿日期:2011-05-06 修回日期:2011-08-04 出版日期:2011-11-05 发布日期:2011-11-05
  • 作者简介:施兵★，男，1973年生，江苏省启东市人，汉族，2002年南通医学院毕业，硕士，主治医师，主要从事血液肿瘤诊治的研究。 taitaiyang@126.com

Granulocyte-colony stimulating factor related lung injury in a leukemia patient during mobilization of peripheral blood stem cells

Shi Bing, Liu Li-hui, Ye Li-ping   

  1. Department of Hematology, the 309 Hospital of PLA, Beijing  100091, China
  • Received:2011-05-06 Revised:2011-08-04 Online:2011-11-05 Published:2011-11-05
  • About author:Shi Bing★, Master, Attending physician, Department of Hematology, the 309 Hospital of PLA, Beijing 100091, China taitaiyang@126.com

PDF

362

被引次数

5

摘要：

背景：使用粒细胞集落刺激因子动员外周血干细胞后导致急性肺损伤仅有零星报道，机制尚不清楚。
目的：探讨应用重组人粒细胞集落刺激因子动员外周血干细胞富集导致肺损伤的临床表现、机制。
方法：报告1例粒细胞集落刺激因子动员外周血干细胞时导致咯血和影像学肺部结节状、片状阴影，并复习相关文献。
结果与结论：粒细胞集落刺激因子可能会导致肺损伤，机制可能和中性粒细胞在肺部聚集、黏附、释放炎症递质有关。

关键词: 粒细胞集落刺激因子, 不良反应, 肺损伤, 外周血干细胞动员

Abstract:

BACKGROUND: There are few studies about granulocyte-colony stimulating factor related lung injury during mobilization of peripheral blood stem cells, but the mechanism is unclear.
OBJECTIVE: To explore the clinical manifestation and possible pathogenic mechanism of acute lung injury related to recombinant human granulocyte-colony stimulating factor.
METHODS: We reported a case of sudden hemoptysis, scattered lung nodular shadows and patchy shadows in a leukemia patient following the administration of granulocyte-colony stimulating factor to mobilize peripheral blood stem cells, and related literatures were also reviewed.
RESULTS AND CONCLUSION: Granulocyte-colony stimulating factor while mobilizing peripheral blood stem cells could induce acute lung injury, which may involve migration of neutrophils to vascular spaces, adhesion of neutrophils to endothelial cells, and potentiation of proinflammatory cytokine expression.

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