中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (45): 8520-8524.doi: 10.3969/j.issn.1673-8225.2011.45.036

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

成体干细胞与肺重建

苏  申，孙海燕，张  彤，吴丽君，姚济荣   

  1. 首都医科大学附属北京世纪坛医院神经内科，北京市  100038
  • 收稿日期:2011-08-25 修回日期:2011-09-21 出版日期:2011-11-05 发布日期:2011-11-05
  • 通讯作者: 姚济荣，主管护师，首都医科大学附属北京世纪坛医院神经内科，北京市 100038 beijingshijitan@163.com
  • 作者简介:苏申，女，1980年生，北京人，汉族，主要从事护理工作。 beijingshijitan@163.com
  • 基金资助:

    国家自然科学基金(81100366)。

Adult stem cells and lung regeneration

Su Shen, Sun Hai-yan, Zhang Tong, Wu Li-jun, Yao Ji-rong   

  1. Department of Neurology, Beijing Shijitan Hospital of Capital Medical University, Beijing  100038, China
  • Received:2011-08-25 Revised:2011-09-21 Online:2011-11-05 Published:2011-11-05
  • Contact: Yao Ji-rong, Nurse in charge, Department of Neurology, Beijing Shijitan Hospital of Capital Medical University, Beijing 100038, China beijingshijitan@163.com
  • About author:Su Shen, Department of Neurology, Beijing Shijitan Hospital of Capital Medical University, Beijing 100038, China beijingshijitan@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 81100366*

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摘要：

背景：肺组织结构复杂，病变周期长，具有主动归巢与调控功能的干细胞植入的治疗手段具有巨大的应用前景。
目的：全面了解成体干细胞治疗肺疾病与损伤的研究进展。
方法：由第一作者检索Pubmed数据库中2011年前发表的有关成体干细胞与肺损伤，多系分化及组织重建等方面的文章，排除重复性研究。
结果与结论：共检索到135篇相关文献，保留其中50篇进行综述。研究表明以骨髓来源的间充质干细胞为代表的成体干细胞具有较强的多系分化潜能，可用于治疗肺部疾病，可参与损伤修复甚至组织再生。其治疗机制及相关影响因素还有待进一步研究。

关键词: 肺, 成体干细胞, 干细胞移植, 肺损伤, 重建

Abstract:

BACKGROUND: Stem cells with active homing function and regulation has a great application prospect to lung regeneration due to the lung tissue with complex structure and long disease cycle.
OBJECTIVE: To overally understand the progress of adult stem cells in treatment of lung diseases and injury.
METHODS: The first author retrieved PuMed for articles about adult stem cells for lung injury published before 2011. Repetitive articles were excluded.
RESULTS AND CONCLUSION: Totally 135 articles were retrieved, and finally 50 articles were included in result analysis. Bone marrow-derived mesenchymal stem cells as the representative of adult stem cells have a strong multi-differentiation potential for the treatment of lung disease, which can involved in wound healing and tissue regeneration. However, the therapeutical mechanism and related influential factors need further studies.

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