中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (41): 7673-7676.doi: 10.3969/j.issn.1673-8225.2011.41.018

• 组织构建与生物活性因子 tissue construction and bioactive factors • 上一篇    下一篇

微支抗种植体及不同矫治力作用下髁突软骨中核心结合因子a1的表达

赵  刚1，邵  鑫1，李德超1，张庆宇2，王  丹1   

  1. 1佳木斯大学附属口腔医院，黑龙江省佳木斯市 154002
    2北京市平谷区中医院麻醉科，北京市 101200
  • 收稿日期:2011-03-19 修回日期:2011-03-23 出版日期:2011-10-08 发布日期:2011-10-08
  • 作者简介:赵刚★，男，1975年生，黑龙江省依兰县人，汉族，硕士，副教授，主要从事牙缺损、缺失及牙颌畸形的修复与矫治方面的研究。 zhaogangkq@ 126.com 并列第一作者：李德超，教授，博士，佳木斯大学附属口腔医院，黑龙江省佳木斯市 154002 dechaoli2004@ yahoo.com.cn

Core binding factor alpha 1 expression in condylar cartilage under different microscrew anchorage orthodontic forces

Zhao Gang1, Shao Xin1, Li De-chao1, Zhang Qing-yu2, Wang Dan1   

  1. 1Hospital of Stomatology, Jiamusi University, Jiamusi  154002, Heilongjiang Province, China
    2Department of Anesthesiology, Pinggu District Hospital of Traditional Chinese Medicine, Beijing  101200, China
  • Received:2011-03-19 Revised:2011-03-23 Online:2011-10-08 Published:2011-10-08
  • About author:Zhao Gang★, Master, Associate professor, Hospital of Stomatology, Jiamusi University, Jiamusi 154002, Heilongjiang Province, China zhaogangkq@126. com Li De-chao, Professor, Doctor, Professor, Hospital of Stomatology, Jiamusi University, Jiamusi 154002, Heilongjiang Province, China dechaoli2004@ yahoo.com.cn Zhao Gang and Li De-chao contributed equally to this paper and were considered as co-first authors.

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440

被引次数

2

摘要：

背景：近年来微支抗种植体以其操作简单、创伤小、支抗强等优点被正畸医生广泛应用于口腔正畸临床，但鲜见用于Ⅱ类颌间的牵引。
目的：以微种植体为支抗，探讨不同矫治力促兔下颌前导后髁突软骨中核心结合因子a1蛋白的表达及与髁突改建的影响。
方法：8 周龄健康新西兰大耳白兔随机分为实验组和对照组，实验组根据矫治力的不同分为100 g、200 g、300 g和 400 g组。实验组动物以微型螺钉种植体为支抗，对兔下颌进行Ⅱ类颌间牵引。实验后4周取材，检测髁突软骨中Cbfa1的表达。
结果与结论：下颌持续牵引后，髁突后区各层的厚度明显高于髁突中前部。与对照组相比随矫治力的增加髁突各层厚度增加，髁突软骨中Cbfa1表达也明显增加，至200 g时达到峰值，而后随矫治力的增加，髁突各层厚度逐渐变薄，髁突软骨中Cbfa1表达也逐渐降低(P < 0.05)，提示矫治力能影响髁突软骨中Cbfa1的表达，说明适宜的矫治力作用有利于髁突软骨的改建。

关键词: 微支抗种植体, 矫治力, 髁突软骨, 核心结合因子&alpha, 1, 改建

Abstract:

BACKGROUND: Recently, microscrew anchorage implant has been widely used in the orthodontics due to its simple operation, little trauma and strong anchorage, but it is rarely used in type Ⅱ intermaxillary extraction.
OBJECTIVE: To establish the animal experiment model of orthodontic microimplant, to investigate the effects of orthodontic forces on the expression of core binding factor a1 (Cbfa1) in condylar cartilage and on condylar process modification.
METHODS: Thirty 8-week-old healthy New Zealand rabbits were randomly divided into experimental group (n=24) and control group (n=6). According to different forces, the experimental group was randomly subdivided into four groups: 100 g, 200 g, 300 g, and 400 g. Rabbits from the experimental group were performed type Ⅱ intermaxillary extraction taking microscrew implants as anchorages. At 4 weeks after surgery, Cbfa1 expression in the condylar cartilage was detected.
RESULTS AND CONCLUSION: Different orthodontic forces resulted in different Cbfa1 expression in the condylar cartilage. When orthodontic force was 100 g and 200 g, Cbfa1 expression was significantly higher compared with the control group and orthodontic force of 200 g lead to highest Cbfa1 expression. When the orthodontic force was 300 g, there was no significant difference between the experimental and control groups (P > 0.05). When orthodontic force was 400 g, Cbfa1 expression was significantly greater in the experimental group than in the control group (P < 0.05). Orthodontic force can influence the expression of Cbfa1 in the condylar cartilage, suggesting that appropriate orthodontic forces have good effects on remodeling condylar cartilage.

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