中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (38): 7201-7204.doi: 10.3969/j.issn.1673-8225.2011.38.041

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

冠状动脉支架置入后相关炎症因子的变化及其干预

余吉西   

  1. 贵州省黔南州人民医院心内科，贵州省都匀市  558000
  • 收稿日期:2011-07-18 修回日期:2011-08-26 出版日期:2011-09-17 发布日期:2011-09-17
  • 作者简介:余吉西，女，1970年生，贵州省瓮安县人，汉族，1992年遵义医学院毕业，副主任医师，主要从事心血管介入治疗临床和基础方面的研究。 gychenlan2011@gmail.com

Changes in inflammatory factors and intervention after coronary stent implantation

Yu Ji-xi   

  1. Department of Cardiology, People’s Hospital of Qiannan Zhou, Duyun  558000, Guizhou Province, China
  • Received:2011-07-18 Revised:2011-08-26 Online:2011-09-17 Published:2011-09-17
  • About author:Yu Ji-xi, Associate chief physician, Department of Cardiology, People’s Hospital of Qiannan Zhou, Duyun 558000, Guizhou Province, China gychenlan2011@ gmail.com

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298

被引次数

9

摘要：

背景：冠状动脉粥样硬化性心脏病支架置入治疗后的炎症反应以及其严重程度与再狭窄明显存在相关性，医学工作者试图从中寻找新思路预防支架置入后再狭窄，提高治疗质量。
目的：评价各种干预措施以及监测手段在冠状动脉置入术后炎症治疗中的应用价值和临床前景。
方法：电子检索EMbase(1980-01/2011-05)，MEDLINE(1966-01/2011-05)，中国生物医学文献数据库(CBM，1978/2011-05)和中国期刊全文数据库(CNKI)，筛查相关文章的参考文献。中文检索词“冠状动脉支架，炎症因子，炎症，CRP，再狭窄”，英文检索词为“Coronary stent，inflammatory cytokines，inflammation，CRP，restenosis”。
结果与结论：临床试验结果显示支架置入后炎症反应明显加重，使用雷帕霉素药物洗脱支架，添加地塞米松、塞来昔布、瑞舒伐他汀等可更大程度上降低支架置入后炎症反应。动物试验发现使用雷帕霉素洗脱支架可减少支架置入段新生内膜的形成和缩小炎症面积。提示各种干预措施可降低支架置入后炎症反应从而降低远期再狭窄的发生，可进一步改良加以应用于临床观察其疗效。

关键词: 冠状动脉, 支架, 再狭窄, 炎症反应, 药物洗脱支架

Abstract:

BACKGROUND: The severity of inflammatory response is obviously correlated with restenosis after coronary stent implantation. Medical workers attempt to find new ideas for the prevention of stent restenosis and improve the quality of treatment.
OBJECTIVE: To evaluate the clinical prospects and value of various interventions and monitoring tools in the treatment of inflammatory response after coronary stent implantation.
METHODS: An electronic search of EMbase (1980-01/2011-05), MEDLINE (1966-01/2011-05), Chinese Biomedical Literature Database (CBM, 1978/2011-05) and CNKI was performed for relevant articles by using the keywords of “Coronary stent, inflammatory cytokines, inflammation, CRP, restenosis” in Chinese and English.
RESULTS AND CONCLUSION: The clinical trials showed that the inflammatory response after stent implantation significantly increased. Inflammatory responses were decreased to a great extent by using sirolimus-eluting stents added with dexamethasone, celecoxib, and rosuvastatin. Animal studies found that the use of sirolimus-eluting stents could reduce neointimal formation of stent segments and inflammatory area. A variety of interventions can reduce the inflammatory response after stent implantation to reduce long-term restenosis; it can be used to further improve the efficacy with clinical observation.

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