中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (38): 7113-7117.doi: 10.3969/j.issn.1673-8225.2011.38.019

• 纳米生物材料 nanobiomaterials • 上一篇    下一篇

纳米羟基磷灰石/羧甲基壳聚糖-海藻酸钠复合骨水泥的性能

肖海军，薛  锋，何志敏，金粉勤，沈玉春   

  1. 上海市奉贤区中心医院骨科，上海市   201400
  • 收稿日期:2011-06-28 修回日期:2011-08-18 出版日期:2011-09-17 发布日期:2011-09-17
  • 通讯作者: 薛锋，上海市奉贤区中心医院骨科，上海市 201400 xuemed@yahoo.com.cn
  • 作者简介:肖海军☆，男，1971年生，四川省中江县人，汉族，2006年解放军第二军医大学毕业，博士，副主任医师，主要从事骨科创伤与修复重建外科研究。 xiaohaijun89@ 163.com
  • 基金资助:

    上海市自然科学基金资助项目(09ZR1426100)，课题名称：新型生物活性人工骨胶粘剂的研制及用于骨折治疗的应用基础研究。

Preparation and characterization of nano-hydroxyapatite/carboxymethychitosan-sodium alginate bone cement composite material

Xiao Hai-jun, Xue Feng, He Zhi-min, Jin Fen-qin, Shen Yu-chun   

  1. Department of Orthopedics, Fengxian District Center Hospital, Shanghai  201400, China
  • Received:2011-06-28 Revised:2011-08-18 Online:2011-09-17 Published:2011-09-17
  • Contact: Xue Feng, Department of Orthopedics, Fengxian District Center Hospital, Shanghai 201400, China xuemed@ yahoo.com.cn
  • About author:Xiao Hai-jun☆, Doctor, Associate chief physician, Department of Orthopedics, Fengxian District Center Hospital, Shanghai 201400, China xiaohaijun89@ 163.com
  • Supported by:

    the Natural Science Foundation of Shanghai City, No. 09ZR1426100*

PDF

401

被引次数

22

摘要：

背景：目前普遍使用的黏合剂对粉碎骨折块进行黏合复位或多或少都存在一些缺陷。
目的：研制具有黏接骨骼作用的生物活性骨水泥。
方法：应用共沉淀法制备纳米羟基磷灰石/羧甲基壳聚糖-海藻酸钠复合材料作为骨水泥的固相粉体，将柠檬酸衍生物配制成溶液作为液相。通过优化实验，从骨水泥的固化时间、抗压强度、抗拉强度、抗稀散性等方面确定最佳配比。
结果与结论：纳米羟基磷灰石/羧甲基壳聚糖-海藻酸钠质量比为65/35，其中羧甲基壳聚糖和海藻酸钠质量比为4∶1时复合成粉体，并按固液比为1.0∶0.5(g∶mL)调拌后形成的骨水泥呈膏状，塑形性和抗稀散性能良好，固化时间12~18 min，抗压强度为(4.5±2.1) MPa。体外黏接猪股骨头抗拉强度在不同室温下无显著性差异无显著性意义(P > 0.05)，固化后2 h的抗拉强度达到24 h的94%。骨水泥为多孔状结构，孔径为100~300 μm，纳米羟基磷灰石分布较均匀。提示制备的纳米羟基磷灰石/羧甲基壳聚糖-海藻酸钠复合骨水泥具有良好的生物活性、适当的力学强度以及较好的黏合强度。

关键词: 纳米羟基磷灰石, 羧甲基壳聚糖, 海藻酸钠, 骨水泥, 优化, 生物材料

Abstract:

BACKGROUND: Bone adhesives have more or few shortcomings themselves at present.
OBJECTIVE: To develop a new kind of bioactive bone cement that can be used as fracture adhesion.
METHODS: Nano-hydroxyapatite/carboxymethychitosan-sodium alginate bone cement composite material as solid phase was prepared through a co-precipitation method, and citric acid derivant as liquid phase was prepared for solution. By optimized experimentation in situ setting, the appropriate prescription of the cement was screened out according to the test of setting time, compressive strength, tensile strength, anti-washout ability, and microstructure and crystal construction of the cement were characterized by using Fourier transform infrared spectroscopy and scanning electron microscope.
RESULTS AND CONCLUSION: When the mass ratio of nano-hydroxyapatite/carboxymethychitosan-sodium alginate was 65/35 (among carboxymethychitosan/sodium alginate 4:1) and liquid/solid was 1.0: 0.5 (g: mL), the prepared cement was paste-like with good plasticity and anti-washout ability; the setting time was 12 to 18 minutes; the compressive strength was (4.5±2.1) MPa; the tensile strength of the femoral head of pigs had no difference at 25 ℃ and 37 ℃ in vitro (P > 0.05); the tensile strength at    2 hours was 94% similar as that at 24 hours after the setting; the range of the porous structure was 100-300 µm; Nano-hydroxyapatite was well-distributed in the porous structure. The nano-hydroxyapatite/carboxymethychitosan-sodium alginate bone cement has good biological activity, appropriate compressive strength, and preferable adhesive strength.

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