中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (34): 6379-6381.doi: 10.3969/j.issn.1673-8225.2011.34.026

• 纳米生物材料 nanobiomaterials • 上一篇    下一篇

透析法制备生物素化高分子纳米粒子及粒径控制

李资玲，熊向源，龚妍春，李玉萍   

  1. 江西科技师范学院生命科学学院，江西省南昌市   330013
  • 收稿日期:2011-03-07 修回日期:2011-05-17 出版日期:2011-08-20 发布日期:2011-08-20
  • 通讯作者: 熊向源，博士，教授，江西科技师范学院生命科学学院，江西省南昌市 330013 xyxiong@gmail.com
  • 作者简介:李资玲★，女，1982年生，江西省资溪县人，汉族，2006年南昌大学生命科学学院毕业，硕士，讲师，主要从事高分子材料的合成研究。 Lzlowen2010@gmail.com
  • 基金资助:

    国家自然科学基金项目(50763003)。

Preparation and size control of biotinylated polymeric nanoparticles by dialysis method

Li Zi-ling, Xiong Xiang-yuan, Gong Yan-chun, Li Yu-ping   

  1. College of Life Science, Jiangxi Science & Technology Normal University, Nanchang  330013, Jiangxi Province, China
  • Received:2011-03-07 Revised:2011-05-17 Online:2011-08-20 Published:2011-08-20
  • Contact: Xiong Xiang-yuan, Doctor, Professor, College of Life Science, Jiangxi Science & Technology Normal University, Nanchang 330013, Jiangxi Province, China xyxiong@gmail.com
  • About author:Li Zi-ling★, Master, Lecturer, College of Life Science, Jiangxi Science & Technology Normal University, Nanchang 330013, Jiangxi Province, China Lzlowen2010@gmail.com
  • Supported by:

    the National Natural Science Foundation of China, No. 50763003 *

PDF

399

被引次数

5

摘要：

背景：国内关于透析法控制粒径大小方面的研究报道较少。
目的：考察制备方式及制备条件等对生物素化高分子纳米粒子粒径大小的影响。
方法：采用透析法制备生物素化两亲性共聚物纳米粒子，通过单因素实验对比纳米粒子粒径的大小。
结果与结论：采用有机相滴加至水相的制备方法获得的粒径大小较适合用于药物载体，且初始有机溶剂加入量对粒径的影响较大。

关键词: 生物素, 两亲性共聚物, 透析法, 纳米粒子, 粒径

Abstract:

BACKGROUND: Few reports about the particle size control by dialysis method have been published in China.
OBJECTIVE: To investigate the effect of preparation method and condition on particle size.
METHODS: Biotinylated polymeric nanoparcticles were prepared by a dialysis method. The particle size was compared by one-factor experimental design.
RESULTS AND CONCLUSION: The size of polymeric nanoparticles obtained from the addition of organic phase into water is pretty suitable for their application in drug delivery carriers. In addition, the amount of initial organic solvent plays an important role in the particle size.

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