中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (33): 6203-6206.doi: 10.3969/j.issn.1673-8225.2011.33.030

• 组织构建与中医药 tissue construction and traditional Chinese medicine • 上一篇    下一篇

丹参素对大鼠牙槽骨代谢的影响

张晓燕1，崔  燎1，吴  铁1，刘运新2   

  1. 1广东医学院药理教研室，广东省东莞市，523808
    2广东医学院门诊部，广东省东莞市，523808
  • 收稿日期:2011-03-05 修回日期:2011-06-09 出版日期:2011-08-13 发布日期:2011-08-13
  • 通讯作者: 吴铁，教授，药学院院长、硕士生导师，广东医学院，广东省东莞市 523808 zxyivy611@163. com 并列通讯作者：崔燎，教授，博士生导师，广东医学院，广东省东莞市，523808 zxyivy611@163. com
  • 作者简介:张晓燕★，女，1978年生，2006年广东医学院毕业，硕士，广东省梅州市人，汉族，讲师，主要从事骨质疏松的研究。 zxyivy611@ 163.com
  • 基金资助:

    课题受广东省科技计划重点项目(A301030201)资助。

Effects of tanshinol on alveoar bone metabolism in rats

Zhang Xiao-yan1, Cui Liao1, Wu Tie1, Liu Yun-xin2   

  1. 1Department of Pharmacology, Guangdong Medical College, Dongguan   523808, Guangdong Province, China
    2Outpatient Department of Guangdong Medical College, Dongguan 523808, Guangdong Province, China
  • Received:2011-03-05 Revised:2011-06-09 Online:2011-08-13 Published:2011-08-13
  • Contact: Wu Tie, Professor, Master’s supervisor, Department of Pharmacology, Guangdong Medical College, Dongguan 523808, Guangdong Province, China Cui Liao, Professor, Doctoral supervisor, Department of Pharmacology, Guangdong Medical College, Dongguan 523808, Guangdong Province, China zxyivy611@163.com
  • About author:Zhang Xiao-yan★, Master, Lecturer, Department of Pharmacology, Guangdong Medical College, Dongguan 523808, Guangdong Province, China zxyivy611@163.com
  • Supported by:

    Technology Plan Key Program of Guangdong Province No.A301030201*

PDF

164

被引次数

3

摘要：

背景：有研究表明胰岛素样生长因子Ⅰ降低是骨丢失的早期标志。
目的：测定大鼠牙槽骨组织中胰岛素样生长因子Ⅰ的活性，探讨丹参素防治牙槽骨骨质疏松症的可能机制。
方法：SD大鼠随机分为对照组、去卵巢组和丹参素组，后两组行双侧卵巢切除，对照组和去卵巢组用蒸馏水灌胃，丹参素组用丹参素12.5 mg/(kg•d)灌胃。给药90 d后取大鼠牙槽骨，检测牙槽骨量、牙槽骨组织中胰岛素样生长因子Ⅰ活性。
结果与结论：与对照组相比，去卵巢组骨小梁面积百分数减少33.88%(P < 0.05)，骨小梁分离度增加43.58%(P < 0.05)，牙槽骨骨量明显减少，牙槽骨组织中胰岛素样生长因子Ⅰ表达变少、变弱(P < 0.05)。与去卵巢组相比，丹参素组骨小梁面积百分数增加了45.45%(P < 0.05)，牙槽骨骨量明显增多，牙槽骨组织中胰岛素样生长因子Ⅰ表达增强(P< 0.05)。结果证实，丹参素能促进牙槽骨组织胰岛素样生长因子Ⅰ活性，防止去卵巢大鼠牙槽骨的丢失。

关键词: 牙槽骨, 骨质疏松, 丹参素, 胰岛素样生长因子Ⅰ, 中医药, 组织构建

Abstract:

BACKGROUND: Decrease in insulin-like growth factor 1 (IGF-1) is an early marker of bone loss.
OBJECTIVE: To determine the activity of IGF-1 in rat alveoar bone tissue and investigate the possible mechanism by which tanshinol prevents alveolar bone osteoporosis.
METHODS: Twenty-four Sprague-Dawley rats were randomly divided into three groups: sham-ovariectomized rats, ovariectomized rats and ovariectomized rats with tanshinol treatment (12.5 mg/kg per day). At 90 days after administration, alveolar bone tissue was taken for detection of bone mass and the activity of IGF-1 in alveolar bone tissue.
RESULTS AND CONCLUSION: Compared with sham-ovariectomized rats, alveolar bone mass was decreased significantly, percentage of trabecular bone was decreased by 33.88% (P < 0.05), trabecular separation was increased by 43.58% (P < 0.05) and IGF-1 expression was markedly decreased (P < 0.05) in ovariectomized rats. Compared with ovariectomized rats, alveoar bone mass was increased significantly, percentage of trabecular bone was increased by 45.45% (P < 0.05) and IGF-1 expression was markedly increased (P < 0.05) in ovariectomized rats with tanshinol treatment. These findings confirm that tanshinol can increase the expression of IGF-1 in alveolar bone tissue and prevent alveoar bone osteoporosis.

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