中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (33): 6103-6106.doi: 10.3969/j.issn.1673-8225.2011.33.006

• 骨组织构建 bone tissue construction • 上一篇    下一篇

兔胫骨骨折模型的不同固定方法

徐自胜，李孝林，任伯绪   

  1. 长江大学医学院，湖北省荆州市 434021
  • 收稿日期:2011-03-06 修回日期:2011-06-20 出版日期:2011-08-13 发布日期:2011-08-13
  • 通讯作者: 任伯绪，教授，硕士生导师。长江大学医学院，湖北省荆州市 434021 boxuren@yahoo.com.cn
  • 作者简介:徐自胜★，男，1981年生，安徽省东至县人，汉族，长江大学医学院在读硕士，主要从事骨科创伤与修复研究。 doctorxzs@ 163.com
  • 基金资助:

    课题受2010年荆州市医疗卫生科技计划项目(荆科技发[2010]14号)资助。

Fixation methods of tibial fracture model in rabbits

Xu Zi-sheng, Li Xiao-lin, Ren Bo-xu   

  1. Medical School of Yangtze University, Jingzhou 434021, Hubei Province, China
  • Received:2011-03-06 Revised:2011-06-20 Online:2011-08-13 Published:2011-08-13
  • Contact: Ren Bo-xu, Professor, Master’s supervisor, Medical School of Yangtze University, Jingzhou 434021, Hubei Province, China boxuren@yahoo.com.cn
  • About author:Xu Zi-sheng★, Studying for master’s degree, Medical School of Yangtze University, Jingzhou 434021, Hubei Province, China doctorxzs@163.com
  • Supported by:

    2010 Medical Science and Technology Plan Projects of Jingzhou City, No. JKJF[2010]14*

PDF

362

被引次数

5

摘要：

背景：利用一种有效的固定方法维持骨折的稳定性是胫骨骨折动物模型成功制备的基础。
目的：观察4种不同的固定方法对兔胫骨骨折模型的固定效果。
方法：将日本大耳白兔截断胫骨骨干后随机分为4组，以4种方法分别固定：①直腿双托组：直腿双托石膏外固定。②塑形双托组：屈膝屈踝双托石膏外固定。③塑形管型组：屈膝屈踝管型石膏外固定。④内外固定组：克氏针内固定+屈膝屈踝双托石膏外固定。
结果与结论：相比其他3组，直腿双托组的外固定石膏脱落时间更早，损伤肢感染率更高(P < 0.05)。在骨折后第4周，内外固定组发生骨折断端移位的实验兔数量最少(P < 0.05)。证实只采用内固定+屈膝屈踝双托石膏外固定才能维持实验兔胫骨骨折的稳定性。

关键词: 兔, 胫骨骨折, 固定, 动物模型, 组织构建 

Abstract:

BACKGROUND: An effective fixation method is the basis to maintain the stability of the fracture in titial fracture models in animals.
OBJECTIVE: To compare the effects of four different fixation methods of tibial fracture model in rabbits.
METHODS: Forty rabbits were randomly divided to four groups (n = 10). Straight legs and double plaster splints group: external fixation of straight legs using double plaster splints; shaping and double plaster splints group: external fixation of flexing knee and ankle using double plaster splints; shaping and plaster cast group: external fixation of flexing knee and ankle using plaster cast fixation method; both internal and external fixation group: internal fixation using kirschner wire and external fixation using double plaster splints on flexing knee and ankle.
RESULTS AND CONCLUSION: The time that plasters fell was earlier and the infection rate of injured limb was higher in the straight legs and double plaster splints group and than in the other three groups (P < 0.05). At the 4th week after fracture, the number of rabbits showing displacement of fracture ends was smallest in both internal and external fixation group (P < 0.05). These findings suggest that only the method that internal fixation using kirschner wire and external fixation using double plaster splints on flexing knee and ankle can maintain the stability of experimental rabbit tibial fracture.

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