中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (12): 2270-2274.doi: 10.3969/j.issn.1673-8225.2011.12.044

• 生物材料综述 biomaterial review • 上一篇    下一篇

胶原蛋白海绵的性质及其临床应用

蔡敏倩1,2，王晓杰1,3，李校堃1,3   

  1. 吉林农业大学，1生物反应器与药物开发教育部工程研究中心， 2生命科学学院，吉林省长春市  130118；3温州医学院，浙江省温州市  325035
  • 收稿日期:2010-09-06 修回日期:2010-10-11 出版日期:2011-03-19 发布日期:2011-03-19
  • 通讯作者: 李校堃，博士，研究员，“长江学者”特聘教授，博士生导师，吉林农业大学生物反应器与药物开发教育部工程研究中心，吉林省长春市 130118；温州医学院，浙江省温州市 325035
  • 作者简介:蔡敏倩★，女，1986年生，吉林省长春市人，汉族，吉林农业大学在读硕士，主要从事生物蛋白海绵的制备及药理、药效方面的研究。
  • 基金资助:

    科技部“重大新药创制”科技重大专项基金资助课题(2008ZX09101-057) ；长春市应用技术研究计划项目资助课题(2008262)；长春市企业科技特派员行动计划项目资助课题(09 KT03)；长春市科技型中小企业技术创新基金资助课题(09C26212203306)。

Properties and clinical application of collagen sponge

Cai Min-qian1,2, Wang Xiao-jie1,3, Li Xiao-kun1,3   

  1. 1Ministry of Education Engineering Research Center of Bioreactor and Pharmaceutical Development, 2College of Life Sciences, Jilin Agricultural University, Changchun  130118, Jilin Province, China; 3Wenzhou Medical College, Wenzhou 325035, Zhejiang Province, China
  • Received:2010-09-06 Revised:2010-10-11 Online:2011-03-19 Published:2011-03-19
  • Contact: Li Xiao-kun, Doctor, Researcher, "Cheung Kong Scholar" Chair Professor, Doctoral supervisor, Ministry of Education Engineering Research Center of Bioreactor and Pharmaceutical Development, Jilin Agricultural University, Changchun 130118, Jilin Province, China; Wenzhou Medical College, Wenzhou 325035, Zhejiang Province, China
  • About author:Cai Min-qian★, Studying for master’s degree, 1Ministry of Education Engineering Research Center of Bioreactor and Pharmaceutical Development, 2College of Life Sciences, Jilin Agricultural University, Changchun 130118, Jilin Province, China e1vira66@qq.com
  • Supported by:

    a grant from Research Fund for the Project of “Major New Medicine Invention” of Science and Technology Ministry, No. 2008ZX09101- 057*; Applied Technology Research Plan Program of Changchun City, No.2008262*; Enterprise Science and Technology Representative Plan Program of Changchun City, No. 09KT03*; Changchun Innovation Fund for Science and Technology-Oriented Small and Medium-Sized Enterprises, No. 09C26212203306*

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摘要：

背景: 胶原蛋白海绵具有良好的功能和特性，及其易于加工、灭菌和保存等独特的优势，被视为最有用途的生物材料，具有广泛的科研和临床应用价值。
目的：介绍胶原蛋白海绵的性质，对近年来胶原蛋白海绵在临床应用上的研究成果进行综述。
方法：由第一作者应用计算机检索2000-01/ 2010-08 Pubmed数据库和Elsevier数据库，在标题和摘要中以 “collagen, collagen sponge, clinical application”为检索词进行检索。检索1993-01/2010-08 CNKI数据库，在标题和摘要中以“胶原，胶原蛋白海绵，临床应用”为检索词进行检索。纳入38篇文献进行综合分析。
结果与结论：胶原蛋白海绵作为一种新型生物材料，越来越广泛地被应用于止血、创面愈合、抗感染、软骨修复、神经修复等相关方面的组织工程与临床研究。但目前所使用的胶原几乎都是来源于动物，无法彻底消除免疫原性。 国外已有人利用生物反应器和转基因技术合成了重组人胶原，其在临床应用上的有效性和安全性等问题仍有待进一步的探索和研究。

关键词: 胶原蛋白海绵, 性质, 止血, 创面愈合, 抗感染, 骨和软骨修复, 神经修复, 临床应用

Abstract:

BACKGROUND: Collagen sponge is considered the most useful biomaterial owing to its excellent function and properties, easy processing, sterilization, and preservation and has been widely used in scientific research and clinical application.
OBJECTIVE: To describe the properties of collagen sponge and to review the research progress of collagen sponge in clinical application in recent years.
METHODS: A computer-based retrieval was performed by the first author to search for manuscripts published from January 2000 to August 2010 in Pubmeds and Elsevier databases and for manuscripts published from January 1993 to August 2010 in CNKI database using key words “collagen, collagen sponge, clinical application” in title and abstract items in English and Chinese language, respectively.
RESULTS AND CONCLUSION: Collagen sponge, as a new biological material, has been widely applied in tissue engineering research in terms of hemostasis, wound healing, anti-infection, cartilage repair, and nerve repair. But at present, nearly all collagen is from animals and immunogenicity cannot be thoroughly eliminated. Researchers outside of China have synthesized recombinant human collagen using bioreactor and transgenic technology, but its efficacy and safety in clinical application needs further investigation and research.

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