中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (12): 2241-2244.doi: 10.3969/j.issn.1673-8225.2011.12.037

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

冠状动脉支架材料与置入后炎症因子的变化

任凤霞1，马  骊2   

  1. 1沈阳师范大学校医院，辽宁省沈阳市  110034
    2沈阳医学院临床实验中心外科手术室，辽宁省沈阳市  110034
  • 收稿日期:2010-12-23 修回日期:2011-02-04 出版日期:2011-03-19 发布日期:2011-03-19
  • 作者简介:任凤霞，女，1966年生，河北省冀县人，汉族，1990年沈阳医学院毕业，主治医师，主要从事心内科工作。 rfx111111@163.com

Changes of inflammatory factors after implantation of coronary artery scaffold material

Ren Feng-xia1, Ma Li2   

  1. 1University Hospital of Shenyang Normal University, Shenyang  110034, Liaoning Province, China
    2Department of Surgery, Experimental Center of Shenyang Medical College, Shenyang  110034, Liaoning Province, China
  • Received:2010-12-23 Revised:2011-02-04 Online:2011-03-19 Published:2011-03-19
  • About author:Ren Feng-xia, Attending physician, University Hospital of Shenyang Normal University, Shenyang 110034, Liaoning Province, China rfx111111@163.com

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被引次数

2

摘要：

目的：总结冠状动脉支架材料及置入后炎症因子变化的关系。
方法：以“冠状动脉支架，生物相容性，炎症因子，细胞因子，血栓”为关键词，采用计算机检索万方数据网1998-01/2010-12相关文章。纳入冠状动脉支架置入后炎症因子水平变化方面的文献，排除重复研究或Mata分析类文章。
结果：冠状动脉内支架置入有可能会引起冠状动脉血管的损伤，促进体内细胞释放炎症因子，通过炎症因子和细胞因子的表达，能很好的反映支架置入后局部血管损伤程度和炎症水平。药物涂层支架能够显著降低支架置入后再狭窄发生率及靶病变再次血运重建率，但显著增加晚期支架血栓形成。通过凝血系统各因子水平评估，药物涂层支架置入前后充分地抗血小板治疗能够降低支架血栓的发生。
结论：支架置入体内后与血液及血管壁接触可产生炎症和致敏反应，因此支架置入前后应充分控制炎症状态和抗凝血治疗。

关键词: 冠状动脉支架, 生物相容性, 炎症因子, 细胞因子, 血栓

Abstract:

OBJECTIVE: To summarize the relationship of coronary artery stent material and changes of inflammatory factor after implantation of coronary artery stent material.
METHODS: A computer-based online search of Wanfang database (1998-01/2010-12) was performed with the key words of “coronary artery stent, biocompatibility, inflammatory factor, cytokine, thrombus” in Chinese. Literatures about changes of inflammatory factor after implantation of coronary artery stent material were included, duplicated and Meta-analysis articles were excluded.
RESULTS: The implantation of stents in coronary artery may lead to the injury of coronary artery, and promote the release of inflammatory factors in vivo cells. According to the expression of inflammatory cytokines and cytokine, it can be well reflected local vascular damage degree and inflammation levels after implantation of scaffold. Drug-eluting stents can significantly reduce incidence of restenosis and rate of target lesion revascularization after implantation of stents, and significantly increase the information of late stent thrombosis.
CONCLUSION: Stents contacted with blood and vessel wall can produce inflammation and sensitization reaction after the implantation of stent in vivo, therefore, inflammation and anti-coagulation therapy should be fully controlled before and after the implantation of stents.

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