中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (10): 1863-1866.doi: 10.3969/j.issn.1673-8225.2011.10.034

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

骨髓间充质干细胞治疗早期股骨头坏死的作用与机制

王  坤，龚跃昆，李  彪，敖小君   

  1. 昆明医学院第一附属医院骨科，云南省昆明市 650032
  • 收稿日期:2010-10-26 修回日期:2010-11-30 出版日期:2011-03-05 发布日期:2011-03-05
  • 作者简介:王坤★，男，云南省昭通市人，汉族，昆明医学院在读硕士，主要从事骨与关节外科研究。 a406364581@sina.com

Effect and mechanism of bone marrow mesenchymal stem cells on the treatment of early avascular necrosis of the femoral head

Wang Kun, Gong Yue-kun, Li Biao, Ao Xiao-jun   

  1. Department of Orthopaedics, First Affiliated Hospital of Kunming Medical College, Kunming  650032, Yunnan Province, China
  • Received:2010-10-26 Revised:2010-11-30 Online:2011-03-05 Published:2011-03-05
  • About author:Wang Kun★, Studying for master’s degree, Department of Orthopaedics, First Affiliated Hospital of Kunming Medical College, Kunming 650032, Yunnan Province, China a406364581@sina.com

PDF

472

被引次数

36

摘要：

背景：骨髓间充质干细胞具有强大的自我增殖能力和分化多潜能性，是治疗早期股骨头坏死的热点。
目的：总结骨髓间充质干细胞的生物学特性及其治疗早期股骨头坏死的方法与机制。
方法：由第一作者检索PubMed数据库(http://www.ncbi.nlm.nih.gov/PubMed)1992-01/2010-10及清华同方中文系列数据库(http://www.cnki.net/index.htm)2000-01/2010-10涉及骨髓间充质干细胞的生物学特性及其治疗早期股骨头坏死内容的文献，英文关键词为“femur head necrosis，mesenchymal stem cell，cell culture，therapy，overview”，中文关键词为“股骨头坏死，骨髓间充质干细胞，细胞培养，治疗，综述”，排除陈旧性、重复性文献，保留30篇文献归纳总结。
结果与结论：利用骨髓间充质干细胞显著的成骨及成血管作用，直接作用于股骨头坏死病灶部位，达到治愈早期股骨头坏死的目的，是目前治疗早期股骨头坏死的热点。今后应进一步分析移植后骨髓间充质干细胞在缺血坏死股骨头内增殖分化的潜能及影响因素、新生血管再狭窄的预防、骨缺损修复的时间，以及骨髓间充质干细胞移植至体内后影响干细胞存活和分化的因素，如局部感染、全身免疫情况等，介入治疗时干细胞是否会随着血流的冲击而流至其他部位，这些问题依然需要进一步解决。

关键词: 骨髓间充质干细胞, 股骨头坏死, 干细胞移植, 细胞培养, 治疗

Abstract:

BACKGROUND: Bone marrow mesenchymal stem cells (BMSCs) have great self-proliferative capacity and pluripotent differentiation, so it becomes a hot spot of the treatment of early avascular necrosis of the femoral head (ANFH).
OBJECTIVE: To summarize the bionomics of BMSCs and its effect and mechanism on the treatment of early ANFH.
METHODS: The literatures were related to the bionomics of BMSCs and its effect and mechanism on the treatment of early ANFH from PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) between January 1992 and October 2010, CNKI database (http://www.cnki.net/index.htm) between January 2000 and October 2010 were retrieved. The index words were “femur head necrosis, mesenchymal stem cell, cell culture, therapy, overview” both in English and in Chinese. Outdated and repetitive researches were excluded, and 30 literatures were included for summarization.
RESULTS AND CONCLUSION: Using osteogenic action and angiogenesis directly treated lesion location of ANFH, so as to achieve the purpose of the treatment of early ANFH, which is the hot spot of the treatment of early ANFH currently. In future, we should further analyze BMSCs in the potential and influential factor of proliferation and differentiation of ischemic ANFH, the prevention of restenosis, the time of bone defects repair and survival and differentiation factors of stem cells after BMSCs transplantation, such as local infection and eneral immunity, and whether stem cells can flow to other sites with the impact of the blood flow during interventional therapy, these problems are still to be further solved.

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