中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (9): 1663-1666.doi: 10.3969/j.issn.1673-8225.2011.09.035

• 骨与关节综述 bone and joint review • 上一篇    下一篇

肿瘤型假体应用与骨巨细胞瘤治疗后的骨缺损重建

刘  威，张绍昆，闫  明，牛  丰   

  1. 吉林大学第一临床医院脊柱外科，吉林省长春市130021
  • 收稿日期:2010-12-03 修回日期:2011-01-17 出版日期:2011-02-26 发布日期:2011-02-26
  • 通讯作者: 张绍昆，博士，副教授，吉林大学第一临床医院脊柱外科，吉林省长春市 130021 drzhangsk@yahoo.com.cn
  • 作者简介:刘威★，男，1981年生，吉林省通化市人，吉林大学第一医院脊柱外科在读硕士，医师，主要从事脊柱外科与组织工程方面的研究。 zyekai@139.com

Application of tumor-type prosthesis and reconstruction of bone defects following treatment of giant cell tumor of bone

Liu Wei, Zhang Shao-kun, Yan Ming, Niu Feng   

  1. Department of Spinal Surgery, First Clinical Hospital, Jilin University, Changchun  130021, Jilin Province, China
  • Received:2010-12-03 Revised:2011-01-17 Online:2011-02-26 Published:2011-02-26
  • Contact: Zhang Shao-kun, Doctor, Associate professor, Department of Spinal Surgery, First Clinical Hospital, Jilin University, Changchun 130021, Jilin Province, China drzhangsk@yahoo.com.cn
  • About author:Liu Wei★, Studying for master’s degree, Physician, Department of Spinal Surgery, First Clinical Hospital, Jilin University, Changchun 130021, Jilin Province, China zyekai@139.com

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281

被引次数

3

摘要：

背景：骨巨细胞瘤传统治疗方法复发率高，而对其机制的日益了解及肿瘤型假体在骨肿瘤切除中的成功应用，为提高骨巨细胞瘤的治疗效果提供了更广阔的前景。
目的：总结肿瘤型假体在骨巨细胞瘤治疗中的作用及该肿瘤目前的治疗进展、发病机制。
方法：应用计算机检索2000-01/2010-10 PubMed数据库、中国知网数据库相关文章，中文检索词为“骨巨细胞瘤，研究进展”，英文检索词为“giant cell tumor of bone，tumor-type prosthesis，therapy research”。共检索到文献475篇，保留符合标准的35篇进行综述。
结果与结论：治疗骨巨细胞瘤的传统方法是手术切除，并根据情况对切除后产生的骨缺损进行重建。将各种骨重建方法进行比较得出，应用肿瘤型假体治疗骨巨细胞瘤效果更好，不仅能使患者获得患肢或患椎的即刻稳定性，而且并发症少，相对于其他的重建方式明显降低了假体置入后复发率，实现了肿瘤的广泛切除。但肿瘤型假体的应用并不能完全避免置入后肿瘤的复发。最近针对骨巨细胞瘤形成信号通路的研究取得了成果，为降低置入后复发率及不能手术的患者提供了新疗法。

关键词: 肿瘤型假体, 骨巨细胞瘤, 骨缺损, 重建, 综述文献

Abstract:

BACKGROUND: The giant cell tumor of bone has a high recurrence rate after traditional treatment; however, with better understanding of its mechanism and the successful application of tumor-type prosthesis, the therapeutic efficacy will be better.
OBJECTIVE: To summarize the application and pathogenesis of tumor-type prosthesis in the treatment of giant cell tumor of bone.
METHODS: A computer-based online search was performed on PubMed and CNKI databases with key words of “giant cell tumor of bone, tumor-type prosthesis, therapy research” from January 2000 to October 2010. Totally 475 documents were initially searched, and 35 papers were included in this review. 
RESULTS AND CONCLUSION: The traditional way to cure giant cell tumor of bone is surgery and the reconstruction work was operated based on the diverse situations of damages of bone caused by surgery. It can be seen that choosing tumor-type prosthesis to cure the giant cell tumor of bone is a better approach, according to the comparision of various bone reconstruction ways. It can not only enable the patients to acquire the instant stability of affected limbs or spines, also has less complication. Compared to other reconstruction ways, it apparently lowers rate of after-surgical recurrence, and makes the tumor be removed extensively. However, the application of tumor-type prosthesis does not implicate the disappearence of the recurrence of after-surgical tumor. Recently, the research of signal path from giant cell tumor of bone has made progress, providing a new therapy for lowering the rate of after-surgical recurrence and inoperable patients, which maybe increase the outcome of the therapy.

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