中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (3): 539-542.doi: 10.3969/j.issn.1673-8225.2011.03.039

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

不同支架材料构建组织工程肌腱的性能评价

杨洪武1，韩  超1，池  强2，赵芸娜3   

  1. 1秦皇岛职业技术学院体育部，河北省秦皇岛市 066311
    2河北科技师范学院体育系，河北省秦皇岛市  066004
    3河北建材职业技术学院体育部，河北省秦皇岛市  066004
  • 收稿日期:2010-11-25 修回日期:2010-12-11 出版日期:2011-01-15 发布日期:2011-01-15
  • 作者简介:杨洪武，男，1969年生，黑龙江省齐齐哈尔市人，汉族，1993年齐齐哈尔大学体育学院毕业，副教授，主要从事体育教学与运动训练研究。 capslock889@163.com

Performance evaluation of tissue engineered tendon reconstructed using different scaffolds

Yang Hong-wu1, Han Chao1, Chi Qiang2, Zhao Yun-na3   

  1. 1Department of Physical Education, Qinhuangdao Vocational College, Qinhuangdao  066311, Hebei Province, China
    2Department of Physical Education, Hebei Normal University of Science and Technology, Qinhuangdao  066004, Hebei Province, China
    3Department of Physical Education, Hebei Vocational & Technical College of Building Materials, Qinhuangdao  066004, Hebei Province, China
  • Received:2010-11-25 Revised:2010-12-11 Online:2011-01-15 Published:2011-01-15
  • About author:Yang Hong-wu, Associate professor, Department of Physical Education, Qinhuangdao Vocational College, Qinhuangdao 066311, Hebei Province, China capslock889@163.com

PDF

422

被引次数

8

摘要：

目的：总结修复肌腱损伤的主要组织工程支架材料及研究进展。
方法：由第一作者采用电子检索的方式，在CNKI数据库中检索1902-01/2010-10有关生物材料应用于组织工程肌腱支架的研究文章，关键词为“重建肌腱，生物材料，人工肌腱，组织工程，支架材料”。排除重复研究、普通综述或Meta分析类文章，筛选纳入18篇文献进行评价。
结果：来源于自然界的天然生物材料主要有蚕丝、小肠黏膜下层、胶原、衍生肌腱支架材料等，保留了组织正常的三维网架结构，组织相容性好，但力学性能较差、降解速度快。人工合成高分子材料主要为聚乳酸和聚羟基乙酸、聚乳酸-聚羟基乙酸共聚物、聚磷酸钙纤维等，但存在亲水性低、细胞黏附性能差的不足。
结论：天然及合成高分子材料作为组织工程支架材料都有各自的优缺点，绝大多数还处于研究阶段，尚未应用于临床，因此改进支架材料的性能是目前研究的主要方向之一。

关键词: 肌腱, 重建, 天然高分子材料, 人工合成高分子材料, 支架材料, 生物相容性

Abstract:

OBJECTIVE: To summarize the main tissue engineered scaffold materials for tendon injury repair and research progress.
METHODS: A computer-based online search of CNKI database from January 1902 to October 2010 was performed by the first author to retrieve studies on the biomaterials used for tissue engineered tendon scaffolds, with key words of “tendon reconstruction, biological materials, artificial tendons, tissue engineering, scaffold materials” in Chinese. Duplicated research, reviews or Meta analysis were excluded, finally 18 articles were selected into the evaluation.
RESULTS: The natural biomaterials include silk, small intestinal submucosa, collagen, derivative tendon scaffold and so on, normal three-dimensional network structure of the tissue is retained, tissue compatibility is good, but mechanical properties are poor and degradation speed is fast. Synthetic polymer materials primarily consist of polylactic acid and polyglycolic acid, polylactic acid-polyglycolic acid copolymer, polyphosphoric acid calcium fibers and so on, but they are low hydrophilic and poor performance of cell adhesion.
CONCLUSION: The natural and synthetic polymer scaffolds for tissue engineering has its own advantages and disadvantages, most of them are still in the research stage and have not been applied to clinical practice, so improving the performance of scaffolds is one of the main directions of current research.

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