中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (1): 151-154.doi: 10.3969/j.issn.1673-8225.2011. 01.034

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

神经干细胞修复脊髓损伤

李  伟，江其生   

  1. 解放军第二炮兵总医院中心实验室，北京市  100088
  • 收稿日期:2010-08-09 修回日期:2010-09-28 出版日期:2011-01-01 发布日期:2011-01-01
  • 作者简介:李伟★，女，1976年生，山东省威海市人，汉族，2002年军事医学科学院毕业，硕士，助理研究员，主要从事基因诊断与肿瘤免疫治疗方面的研究。 wei_v@sina.com

Neural stem cells for repairing spinal cord injury

Li Wei, Jiang Qi-sheng   

  1. Central Laboratory, General Hospital of the Second Artillery of Chinese PLA, Beijing  100088, China
  • Received:2010-08-09 Revised:2010-09-28 Online:2011-01-01 Published:2011-01-01
  • About author:Li Wei★, Master, Assistant researcher, Central Laboratory, General Hospital of the Second Artillery of Chinese PLA, Beijing 100088, China wei_v@sina.com

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476

被引次数

8

摘要：

背景：神经生物学和干细胞技术的发展．使通过细胞移植增加脊髓神经数量、减少胶质瘢痕和空洞的形成成为可能。
目的：复习相关文献，就神经干细胞的鉴定及特性、神经干细胞修复脊髓损伤的可能机制、临床前研究及临床应用方面进行综述。
方法：以 “neural stem cells，transplant，spinal cord injury”为英文检索词，以“神经干细胞，移植，脊髓损伤” 为中文检索词，由第一作者检索1997/2010 PubMed数据库及万方数据库有关神经干细胞鉴定、特性、神经干细胞修复脊髓损伤的可能机制、临床前研究及临床应用方面等方面的文章。排除发表时间较早、重复及类似研究，对29篇符合标准的文献进行归纳总结。
结果与结论：神经干细胞有产生神经元、少突胶质细胞、星形胶质细胞，并替代受损的神经细胞功能等。文章从神经干细胞的鉴定及特性，神经干细胞修复脊髓损伤的可能机制，神经干细胞治疗脊髓损伤的实验研究及临床应用等方面进行了讨论。关于干细胞来源的神经元或胶质细胞移植后的长期生存及表型稳定性，以及逃脱分化及选择性程序的很少部分胚胎干细胞，可能会自在移植后的移植位点扩增并形成肿瘤等问题有待进一步解决。

关键词: 神经干细胞, 移植, 脊髓损伤, 细胞移植, 综述文献

Abstract:

BACKGROUND: The development of neurobiology and stem cell technique increases the number of spinal nerves, reduces glial scar and forms cavities by cell transplantation.
OBJECTIVE: To review the identification and characteristics of neural stem cells (NSCs), the possible mechanism, clinical study and clinical application of NSCs for repairing spinal cord injury.
METHODS: The key words were “neural stem cells, transplant, spinal cord injury”. The first author retrieved PubMed database and Wanfang database for articles of the identification and characteristics of NSCs, the possible mechanism, clinical study and clinical application of NSCs for repairing spinal cord injury published from 1997 to 2010. Articles published earlier, repetitive ones and similar studies were excluded. A total of 29 articles accorded with inclusion criteria were included for this review.
RESULTS AND CONCLUSION: NSCs have the ability to differentiate into neurons, astrocytes, oligodendrocytes and can replace the damaged neural cells. The articles discussed the identification and characteristics of NSCs, the possible mechanism, clinical study and clinical application of NSCs for repairing spinal cord injury. Some problems should be solved in the future study, including long-term survival and phenotypic stability of stem cells-derived neurons or glial cells following transplantation, whether a few embryonic stem cells of escape differentiation and selective program will amplify in the transplant site and form tumors.

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