中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (44): 8311-8314.doi: 10.3969/j.issn.1673-8225.2010.44.035

• 器官移植学术探讨 academic discussion of organ transplantation • 上一篇    下一篇

睾丸支持细胞的生物学特性及研究进展

余晓晖，胡云飞   

  1. 武汉大学人民医院泌尿外科，湖北省武汉市 430060
  • 出版日期:2010-10-29 发布日期:2010-10-29
  • 通讯作者: 胡云飞，博士，主任医师，武汉大学人民医院泌尿外科，湖北省武汉市 430060 hyf6606@163.com
  • 作者简介:余晓晖★，男，1984年生，湖北省鄂州市人，汉族，武汉大学在读硕士，主要从事肾移植、膀胱肿瘤方面的研究。 yuxiaohi06@126.com

Biological characteristics and research progress of sertoli cells

Yu Xiao-hui, Hu Yun-fei   

  1. Department of Urology Surgery, Renmin Hospital of Wuhan University, Wuhan   430060, Hubei Province, China
  • Online:2010-10-29 Published:2010-10-29
  • Contact: Hu Yun-fei, Doctor, Chief physician, Department of Urology Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China hyf6606@163.com
  • About author:Yu Xiao-hui★, Studying for master’s degree, Department of Urology Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China yuxiaohui06@126.com

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1722

被引次数

29

摘要：

背景：睾丸支持细胞已成为细胞培养技术、组织工程及器官移植领域的研究热点之一，在临床移植领域中有良好的应用前景。
目的：就国内外对睾丸支持细胞的生物学特性及临床应用进展作一综述。
方法：应用计算机检索CNKI和Pubmed数据库中1998-01/2009-10关于睾丸支持细胞的文章，在标题和摘要中以“免疫豁免；移植；功能；研究进展”或“immune privilege；transplantation; function; progress of investigate”为检索词进行检索。选择文章内容与睾丸支持细胞有关者，同一领域文献则选择近期发表或发表在权威杂志文章。初检得到215篇文献，根据纳入标准选择关于睾丸支持细胞的34篇文献进行综述。
结果与结论：睾丸支持细胞具有分泌多种营养因子和免疫豁免功能，为器官移植、帕金森病及糖尿病等疾病的治疗提供了新的治疗途径，对睾丸支持细胞的研究已经取得了一系列可喜的成果，将会给人类临床事业的发展作出巨大贡献，尤其随着组织工程和器官移植研究的发展，睾丸支持细胞在临床治疗中的应用必将更加广泛。

关键词: 睾丸支持细胞, 功能, 研究进展, 综述文献, 器官移植

Abstract:

BACKGROUND: Sertoli cell has become one of the research focuses in the fields of cell separation, tissue engineering and organ transplantation, and it has a promising application in clinical transplantation.
OBJECTIVE: To summarize the biological characteristics and research progress of sertoli cell at home and abroad.
METHODS: Articles addressing sertoli cell were retrieved from CNKI and Pubmed databases with the key words of “immune privilege, transplantation, function, progress of investigate” in both Chinese and English between January 1998 and October 2009. Articles in the same circle published in the authoritative journals or recently published were selected. There were 215 articles after the initial survey, and 34 articles related sertoli cell were included in the final analysis.
RESULTS AND CONCLUSION: Sertoli cell has the function of immune privilege and can secrete various nutrition factors. And it is widely drawn by providing new therapy for organ transplantation, Parkinson disease and diabetes mellitus. The research about sertoli cell has achieved a lot and presented an extremely captivating prospect in clinical field. It will make a great contribution to the clinical development of mankind. The clinical application of sertoli cell will be wider along with the development of transplantation of tissue engineering and organ transplantation.

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