中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (26): 4878-4881.doi: 10.3969/j.issn.1673-8225.2010.26.032

• 骨与关节学术探讨 academic discussion of the bone and joint • 上一篇    下一篇

椎弓根螺钉在胸腰椎骨折置入内固定治疗中的应用及其生物相容性

肖旭阳，王晓东，藏东玉   

  1. 辽宁医学院附属第一医院胸外科，辽宁省锦州市121001
  • 出版日期:2010-06-25 发布日期:2010-06-25
  • 通讯作者: 王晓东，主任医师，辽宁医学院附属第一医院胸外科，辽宁省锦州市 121001
  • 作者简介:肖旭阳，男，1979年生，辽宁省大连市人，汉族，2003年辽宁医学院毕业，硕士，住院医师，主要从事肺癌的个体化治疗研究。 xiaoxuyang1234@163.com

Application and biocompatibility of pedicle screws in thoracolumbar fracture internal fixation

Xiao Xu-yang, Wang Xiao-dong, Zang Dong-yu   

  1. Department of Thoracic Surgery, First Hospital of Liaoning Medical University, Jinzhou  121001, Liaoning Province, China
  • Online:2010-06-25 Published:2010-06-25
  • Contact: Wang Xiao-dong, Chief physician, Department of Thoracic Surgery, First Hospital of Liaoning Medical University, Jinzhou 121001, Liaoning Province, China
  • About author:Xiao Xu-yang, Physician, Department of Thoracic Surgery, First Hospital of Liaoning Medical University, Jinzhou 121001, Liaoning Province, China xiaoxuyang1234@163.com

PDF

394

被引次数

24

摘要：

目的：阐述椎弓根螺钉在胸腰椎骨折内固定治疗中的应用进展，并评价其生物相容性。
方法：第一作者应用计算机检索PubMed(1989/2009)数据库，检索关键词“Pedicle screws，thoracolumbar，fractures，biocompatibility”，限定语言种类为English；同时检索CNKI(1989/2009)数据库，检索关键词“椎弓根螺钉，胸腰椎，骨折，生物相容性”，限定语言种类为中文。共检索到57篇文章，按纳入和排除标准对文献进行筛选，最终纳入31篇文章。
结果：后路椎弓根螺钉内固定系统是治疗胸腰椎骨折的有效方法，但内固定后易发生椎弓根螺钉断裂。联合椎弓根螺钉系统和向伤椎空腔内置入自体骨或人工材料，可以有效减少置入物的松动、断裂等并发症，但价格昂贵。内固定时充分植骨，骨折愈合后适时取出置入物能有效的防止脊柱内固定器的断裂。不锈钢材料的椎弓根螺钉强度较大，但组织相容性差。钛类内固定材料的生物相容性较好，但其刚度较小，容易断裂。
结论：椎弓根螺钉内固定系统是治疗胸腰椎骨折的最有效手段。各种椎弓根螺钉的生物相容性均有待提高，钛类椎弓根螺钉组织相容性较好，其刚度需要提高，不锈钢材料椎弓根螺钉刚度较好，但其生物相容性较差。

关键词: 椎弓根螺钉, 胸腰椎骨折, 断裂, 内固定, 生物相容性

Abstract:

OBJECTIVE: To discuss application of pedicle screws in thoracolumbar fractures internal fixation and evaluate the biocompatibility.
METHODS: A computer-based online search of PubMed database (1989/2009) and CNKI (1989/2009) was performed with key words “pedicle screws, thoracolumbar, fractures, biocompatibility” in English and Chinese. A total of 57 articles were collected, and 31 were included according to inclusion and exclusion criteria.
RESULTS: Posterior pedicle screw internal fixation system is an effective tool for thoracolumbar fractures. However, the screw breakage frequently occurs. Pedicle screw internal fixation in combination with autologous bone or artificial materials in cavity of lesioned vertebra effectively reduces implant loosening, breakage, but the cost is high. Full bone implants in internal fixation and withdrawal following fracture healing can effectively prevent spinal fixator breakage. Pedicle screws of stainless steel have great intensity, but poor histocompatibility. The biocompatibility of titanium materials for internal fixation is good, but their rigidity is small.
CONCLUSION: Pedicle screw internal fixation system is an effective method for thoracolumbar fractures. The biocompatibility of various pedicle screws requires improvement. For example, the biocompatibility of titanium materials for internal fixation is good, but their rigidity is poor, while the stainless steel has great intensity, but poor histocompatibility.

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