中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (20): 3753-3756.doi: 10.3969/j.issn.1673-8225.2010.20.034

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

增生性瘢痕的防治现状与展望

高明月1，蔺 洁2，张文显1   

  1. 1河北省儿童医院整形外科，河北省石家庄市 050031； 2河北省人民医院整形外科，河北省石家庄市  050031
  • 出版日期:2010-05-14 发布日期:2010-05-14
  • 作者简介:高明月，女，1966年生，河北省石家庄市人，汉族，2001年山西省长治医学院毕业，主管护师，主要从事小儿先天畸形、血管瘤及瘢痕等的诊治工作。 gaomingyue518@sohu.com

Prevention and treatment of hypertrophic scars and the clinical prospect

Gao Ming-yue1, Lin Jie2, Zhang Wen-xian1     

  1. 1Department of Plastic Surgery， Children’s Hospital of Hebei, Shijiazhuang 050031, Hebei Province, China; 2Department of Plastic Surgery， People’ s Hospital of Hebei Province, Shijiazhuang 050031, Hebei Province, China
  • Online:2010-05-14 Published:2010-05-14
  • About author:Gao Ming-yue, Nurse-in-charge, Department of Plastic Surgery, Children’ s Hospital of Hebei Province, Shijiazhuang 050031, Hebei Province, China gaomingyue518@sohu.com

PDF

574

被引次数

56

摘要：

背景：增生性瘢痕是创伤愈合的异常结局，严重影响体表美观并导致功能障碍。

目的：综述国内外关于增生性瘢痕的防治现状与研究概况。

方法：应用计算机检索PubMed数据库、EMbase数据库1960-01/2009-01期间相关文章，检索词为“hypertrophic scars，Prevention，treatment”，并限定文章语言种类为English。同时计算机检索中国生物医学文献数据库、中文科技期刊全文数据库、中文学术期刊全文数据库1999-01/2009-01期间相关文章，检索词为“增生性瘢痕”，并限定文章语言种类为中文。此外还手工查阅相关专著数部。纳入增生性瘢痕的生物学特性、增生性瘢痕的形成原因、增生性瘢痕的临床防治研究类文献。

结果与结论：增生性瘢痕的成因来源于成纤维细胞的生物学特性异常，成纤维细胞数量增多，合成并分泌大量的胶原纤维，是瘢痕组织形成的关键环节。对于增生性瘢痕应防治结合，在创伤愈合早期采取预防措施，抑制瘢痕形成，包括硅凝胶防治、药物治疗、激光治疗、放射疗法、冷冻疗法。治疗应采取几种方法联合的综合疗法，比单一疗法效果显著。另外，近几年中药在瘢痕的作用机制、动物实验及剂型改造方面研究层出不穷，加强中医药在防治增生性瘢痕方面的研究很重要。提示增生性瘢痕的防治应从源头上避免或减轻异常瘢痕的发生发展，寻找瘢痕基因缺陷并从基因水平加以修正，中医药在防治增生性瘢痕方面前景广阔有待进一步突破。

关键词: 增生性瘢痕, 生物特性, 预防, 治疗, 皮肤组织工程, 综述文献

Abstract:

BACKGROUND: Hyperplastic scar is the abnormal results of wound healing, which severely effects body appearance and leads to functional disturbance.

OBJECTIVE: To review the prevention and treatment of hypertrophic scar status in China and abroad.

METHODS: PubMed, Embase, Chinese Biomedical Literature Database, CNKI, CAJ were retrieved by computer with key words of “hypertrophic scars, prevention and treatment”. The language was limited for English and Chinese. Simultaneously, related monograph was manually searched. The studies regarding biological features of hypertrophic scar, reasons for hypertrophic scar formation, as well as prevention and treatment of hypertrophic scar were included in the analysis.

RESULTS AND CONCLUSION: The main causes of hypertrophic scar fibroblasts are biological characteristics of abnormal increase in the number of fibroblasts. A large number of collagen fibers synthesized and secreted is the key to the formation of scar tissue. The prevention and treatment of hypertrophic scar should be integrated early in wound healing to take preventive measures to curb scar. Treatment should be combined in several ways to take combination therapy, which received notable results compared with monotherapy. In addition, in recent years the role of Chinese medicine in the mechanism of scar formation, animal experiments and dose reconstruction studies are endless. Strengthening of Chinese medicine in prevention and treatment of hypertrophic scar research is very important. The occurrence and development of abnormal scars should be thoroughly avoided or reduced from the source, genetic level defects should be amended to prevent and treat hypertrophic scars. Traditional Chinese medicine can be a further breakthrough in the prevention and treatment of hypertrophic scars.

中图分类号: