中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (11): 2026-2029.doi: 10.3969/j.issn.1673-8225.2010.11.032

• 组织构建综述 tissue construction review • 上一篇    下一篇

失神经支配的骨骼肌萎缩与防治

赵  磊1，严志强2，吕广明3   

  1. 1南通大学医学院第三附属医院骨科，江苏省无锡市 214041；
    2上海交通大学医学院力学生物学与医学工程实验室，上海市  200030；
    3南通大学江苏省神经再生重点实验室，江苏省南通市 226001
  • 出版日期:2010-03-12 发布日期:2010-03-12
  • 作者简介:赵 磊，男，1973年生，江苏省泰州市人，汉族，1996年南通大学医学院毕业，硕士，主治医师，主要从事周围神经损伤与再生的研究。 doctor_zhao@sohu.com

Prevention and treatment of denervated skeletal muscle amyotrophy

Zhao Lei1, Yan Zhi-qiang2, Lü Guang-ming3   

  1. 1Department of Orthopedics, Third Affiliated Hospital of Nantong University School of Medicine, Wuxi   214041, Jiangsu Province, China;
    2Laboratory of Mechanics, Biology and Medical Engineering, Shanghai Jiao Tong University School of Medicine, Shanghai   200030, China;
    3Jiangsu Provincial Key Laboratory of Nerve Regeneration, Nantong University, Nantong   226001, Jiangsu Province, China
  • Online:2010-03-12 Published:2010-03-12
  • About author:Zhao Lei, Master, Attending physician, Department of Orthopedics, Third Affiliated Hospital of Nantong University School of Medicine, Wuxi 214041, Jiangsu Province, China doctor_zhao@sohu.com

PDF

391

被引次数

10

摘要：

背景：随着当今医学的发展，失神经支配骨骼肌萎缩的防治已取得了显著的进步，但临床疗效仍不十分满意。
目的：对失神经支配骨骼肌萎缩防治方法的研究现状作一总结，试图寻找更为有效的失神经支配骨骼肌萎缩防治方法。
方法：以denervation，muscle atrophy，treatment为检索词，检索Medline数据库(1998-01/2008-01)。以失神经，肌萎缩，治疗为检索词，检索中国期刊全文数据库(1998-01/2008-01)、万方数据库(1998-01/2008-01)和《中国临床康复》杂志(1998-01/2008-01)。文献检索语种限制为英文和中文。以肌肉的耐力及收缩力、失神经的肌湿重和骨骼肌的修复情况为评价指标。纳入研究失神经支配骨骼肌萎缩的显微外科手术方法、物理疗法、生物和化学疗法、基因疗法。排除上述方法之外失神经支配骨骼肌萎缩的其他疗法。
结果与结论：周围神经损伤后，骨骼肌失神经支配将不可避免的发生萎缩。因此，探索失神经支配骨骼肌萎缩的防治方法，吸引了国内外许多学者的兴趣，必将成为21世纪周围神经领域内的重要任务和研究热点。显微外科手术、物理疗法、生物和化学疗法、基因疗法等都是失神经支配骨骼肌萎缩有效的防治手段。目前，该领域的研究已经呈现多角度、多方面的趋势。失神经肌萎缩的防治方面已经有了针对性的措施，但在改善微循环、防止细胞凋亡、抑制胶原过度生长以及如何应用基因治疗的方法在基因水平改变生肌调节因子的表达等方面，还有大量工作需要进行。随着组织工程学、细胞培养学、分子生物学、基因工程等方面的不断发展，防治失神经肌萎缩必定会有新的突破。

关键词: 失神经, 骨骼肌, 萎缩, 防治, 肌肉肌腱组织工程, 综述文献

Abstract:

BACKGROUND: Along with the medicine development, the prevention and treatment of the atrophy of denervated skeletal muscle have made a remarkable progress, but the clinical curative effect is still not satisfied.
OBJECTIVE: To summarize the current status of the prevention and treatment methods of denervated skeletal muscle atrophy, and to find a more effective method for the prevention and treatment of the denervated of skeletal muscle atrophy.
METHODS: Using “denervation, muscle atrophy, treatment” in English for the search term, Medline database from January 1998 to January 2008 was retrieved. Using “denervation, muscle atrophy, treatment: in Chinese for the search term, the Chinese Journal Full-text Database from January 1998 to January 2008, Wanfang Database from January 1998 to January 2008, and Journal of Clinical Rehabilitation and Tissue Engineering Research from January 1998 to January 2008 were searched. Literature was limited to English and Chinese languages. The muscular endurance and contractile force, muscle wet weight of denervated nerve, and skeletal muscle repair served as the evaluation index. The studies on the micro-surgical procedures, physical therapy, biological and chemical therapies, gene therapy for the atrophy of denervated skeletal muscle were included. Except the above methods, other therapies to the denervated skeletal muscle atrophy were excluded.
RESULTS AND CONCLUSION: After peripheral nerve damage, the skeletal muscle is denervated and then inevitably atrophy occurs. Therefore, the exploration of prevention and treatment of denervated skeletal muscle atrophy has attracted the interests from many domestic and foreign scholars, will certainly become the important task and the research hot spot in the 21st century in the peripheral nerve domain. The microsurgery surgery, physiotherapy, biology and chemotherapeutics, gene therapy are the main effective prevention methods for the atrophy of denervated skeletal muscle. At present, this domain's research already presents the multiple perspectives and various tendencies. The prevention and treatment of denervated skeletal muscle atrophy has already given the pointed management, but in the improvement microcycle, but much works need to carry on in fields of improving microcirculation, preventing cell apoptosis, suppressing the collagen excessive growth, as well as adjusting myogenic regulatory factors expression using gene therapy method in the gene level, but also had the. Along with the tissue engineering, cell culture science, molecular biology, genetic engineering and so on, an unceasing development will be obtained regarding the prevention and treatment of denervated skeletal muscle atrophy.

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