关键词: Notch信号通路, 骨关节炎, 软骨细胞, 骨组织工程, 软骨组织工程, 综述文献

Abstract:

BACKGROUND: Osteoarthritis, often accompanied by cartilage abnormal signal transduction, suggesting that intracellular signal transduction may play an important role in osteoarthritis genesis and development.
OBJECTIVE: To review recent advances in the research of Notch signaling pathway, and explore the mechanisms of chondrogenic differentiation of bone marrow mesenchymal stem cells and its role in cartilage development and chondrogenesis. To analysis the role of dysregulated Notch signaling in the development of osteoarthritis.
METHODS: Pubmed was undertaken to identify the relevant articles published from March 1919 to February 2009 with the key words of “Notch signaling pathway, osteoarthritis, chondrocytes, chondrogenesis, bone marrow stem cells” in English. Simultaneously, CNKI Database was searched for relevant articles published from February 2004 to September 2008 with the key words of “Notch signaling pathway, osteoarthritis, chondrocytes, chondrogenesis, bone marrow stem cells” in Chinese. Articles with the Notch signaling pathway-related research, Notch signaling pathway of bone marrow-derived mesenchymal stem cells, differentiation of cartilage relative to the mechanism studies, and the Notch signaling pathway disorders and osteoarthritis research were included. Reproducibility articles were excluded. Development regulation of articular cartilage and cartilage cell proliferation were considered as evaluation indexes.
RESULTS AND CONCLUSION: Of 632 articles retrieved, 30 were included in our study according to the inclusive and exclusive criteria. The Notch pathway is a highly conserved signaling mechanism involved in many processes determining cell fate during development and maintenance of homeostasis of mature tissues in the adult organism. Activation of Notch occurs following Notch receptor/ligand engagement upon cell-cell contact, which initiates translocation of the Notch intracellular domain to the nucleus and activation of target genes. It has been demonstrated that the Notch signaling plays an important role in regulating articular cartilage development and chondrocyte proliferation and differentiation. In recent studies abnormality of notch signaling was also found in disease, which suggests that notch signaling is involved in osteoarthritis initiation and development. Further study of the specific mechanism of notch signaling in the initiation and development of osteoarthritis will enable us to develop targeted approaches in the treatment of osteoarthritis, thus bring more strategies in the future treatment of osteoarthritis.