中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (49): 9281-.doi: 10.3969/j.issn.1673-8225.2010.037

• 干细胞学术探讨 • 上一篇    下一篇

骨髓间充质干细胞诱导分化及在视网膜疾病中的应用

张克剑1，刘学政1，侯阳1，张明锐2   

  1. 1辽宁医学院解剖教研室，辽宁省锦州市 121001； 2吉林大学口腔医院，吉林省长春市 130021
  • 出版日期:2010-12-03 发布日期:2010-12-03
  • 通讯作者: 刘学政，博士后，教授，辽宁医学院解剖教研室，辽宁省锦州市 121001 liuxuezheng168@vip.sina.com
  • 作者简介:张克剑★，男，1981年生，宁夏回族自治区固原市人，汉族，辽宁医学院在读硕士，主要从事骨髓间充质干细胞治疗糖尿病视网膜病变的研究。 kejianzhang88@163.com
  • 基金资助:

    锦州市科技计划资助项目(0222121)。

Application of induced differentiation of bone marrow mesenchymal stem cells to retinal diseases

Zhang Ke-jian1, Liu Xue-zheng1, Hou Yang1, Zhang Ming-rui2   

  1. 1Department of Anatomy, Liaoning Medical University, Jinzhou  121001, Liaoning Province, China; 2Hospital of Stomatology Affiliated to Jilin University, Changchun  130021, Jilin Province, China
  • Online:2010-12-03 Published:2010-12-03
  • Contact: Liu Xue-zheng, Doctor, Professor, Department of Anatomy, Liaoning Medical University, Jinzhou 121001, Liaoning Province, China liuxuezheng168@vip.sina.com
  • About author:Zhang Ke-jian★, Studying for master’s degree, Department of Anatomy, Liaoning Medical University, Jinzhou 121001, Liaoning Province, China kejianzhang88@163.com
  • Supported by:

    the Science and Technology Project of Jinzhou City, No. 0222121*

PDF

405

被引次数

10

摘要：

背景：近年来诸多研究已经报道了骨髓间充质干细胞分化为神经元样细胞并能与原视网膜结构发生融合，且可治疗部分视网膜变性。
目的：分析总结骨髓间充质干细胞的生物学特性及其在视网膜疾病中的研究与应用。
方法：应用计算机检索CNKI和PubMed数据库中1995-01/2010-05关于“骨髓间充质干细胞在视网膜疾病中的研究与应用”的文章，以“骨髓间充质干细胞，视网膜”或“视网膜疾病” 为检索词进行检索。选择文章内容与骨髓间充质干细胞治疗视网膜疾病相关，同一领域文献则选择近期发表或发表在权威杂志文章。初检得到中英文共286篇文献，根据纳入标准选择29篇文章进行综述。
结果与结论：骨髓间充质干细胞有向视网膜样细胞分化的能力，具有分化为视网膜神经细胞以修补受损视网膜的可能性，骨髓间充质干细胞可以分化为视网膜神经细胞，并能够帮助损伤的视网膜重新修复，骨髓间充质干细胞视网膜下移植可用于一些视网膜变性的治疗。然而，目前骨髓间充质干细胞移植后分化为视网膜细胞还不理想，诱导分化的机制还不清楚，故视网膜下移植的途径及移植后的效果还需要进一步的研究。

关键词: 视网膜病变, 骨髓间充质干细胞, 移植途径, 诱导, 分化

Abstract:

BACKGROUND: Recent studies indicate that bone marrow mesenchymal stem cells (BMSCs) could differentiate into neuron-like cells, have the fusion with the original retina structure and can be part of the treatment of retinal degeneration. 
OBJECTIVE: To conclude and analyze biological characteristics of BMSCs and their clinical application in retinopathy. 
METHODS: China National Knowledge Infrastructure and PubMed Database were searched by computer for articles on research and application of BMSCs in retinopathy published from January 1995 to May 2010. The key words were “bone marrow mesenchymal stem cells, retina” or “retinopathy”. The related articles about BMSCs for retinopathy were included, and those published recently or in authorized journals in the same field were included. A total of 286 articles were primarily collected. In accordance with inclusion criteria, 29 articles were used for this review.
RESULTS AND CONCLUSION: BMSCs have the potential of differentiating into retina-like cells, and possibility of differentiating into retinal nerve cells to repair damaged retina. BMSCs can differentiate into retinal nerve cells, help damaged retina to repair. BMSCs transplantation in retina can be used to treat retinal degeneration. However, at present, it is not ideal to differentiate into retinal cells following BMSCs transplantation. The mechanism of induced differentiation remains unclear. Thus, the pathway of retinal transplantation and posttransplanted outcomes require further investigations.

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