中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (2): 317-320.doi: 10.3969/j.issn.1673-8225.2010.02.030

• 组织构建综述 tissue construction review • 上一篇    下一篇

骨转换指标和骨密度预测骨折危险性的可行性　

林坚平，宋世锋，姚伦龙   

  1. 海南省人民医院创伤骨科，海南省海口市 570311 
  • 出版日期:2010-01-08 发布日期:2010-01-08
  • 作者简介:林坚平★，男，1971年生，海南省儋州市人，汉族，1993年北京医科大学医疗系毕业，硕士，副主任医师，主要从事骨愈合分子生物学方面的研究。 linescu@163.com

Feasibility of predicting fracture risk with bone turnover markers and bone mineral density

Lin Jian-ping, Song Shi-feng, Yao Lun-long   

  1. Department of Orthopedic Surgery, Hainan Provincial People's Hospital, Haikou    570311, Hainan Province, China 
  • Online:2010-01-08 Published:2010-01-08
  • About author:Lin Jian-ping★, Master, Associate chief physician, Department of Orthopedic Surgery, Hainan Provincial People's Hospital, Haikou 570311, Hainan Province, China linescu@163.com.

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摘要：

背景：骨密度虽然可以诊断骨质疏松，但不能及时反映受试者正在发生的骨代谢情况;骨转换指标虽然不能诊断骨质疏松，但它可以及时反映受试个体正在发生的骨转换速率。
目的：概述骨转换指标和骨密度预测骨质疏松症的骨折危险性，从理论上分析，骨折术后愈合与否的预测方法的可行性。
方法：以bone tunrnover，biochemical marker，osteoporosis为检索词，检索Pubmed数据库(1999-01/2009-01)；以骨转换，骨代谢，生化标志物，骨密度，骨质疏松，骨折为检索词，检索CNKI数据库(1999-01/2009-01)。文献检索语种限制为英文和中文。纳入与骨转换指标和骨密度预测骨折危险性的研究紧密相关的文章；排除重复文献。
结果与结论：计算机初检得到631篇文献，根据纳入排除标准，对其中31篇文献进行分析。骨质疏松症是老年人发病及死亡的主要原因之一，早期预测骨质疏松症的骨折危险性意义重大。文章介绍了长期制动后的骨代谢机制、骨生化标志物种类、骨密度测量、多细胞基本单位和 OPG-RANKL-RANK 系统在骨重建中的作用；重点介绍了国内外学者运用骨转换指标和骨密度预测骨质疏松症和长期制动后的骨折危险性，从理论上分析骨折术后愈合与否的预测方法的可行性。

关键词: 骨转换, 生化标志物, 骨密度, 骨质疏松, 骨组织工程, 综述文献

Abstract:

BACKGROUND: Although bone mineral density can diagnose osteoporosis, it cannot reflect the existing bone metabolism of the subjects; bone turnover markers cannot diagnose osteoporosis, but it can timely reflect the current bone turnover rate of the subjects.
OBJECTIVE: To summarize osteoporotic fracture risk predicted by bone turnover markers and bone mineral density, and to theoretically analyze the feasibility of fracture healing after operation.
METHODS: With bone turnover, biochemical marker, osteoporosis in English for the search terms, Pubmed database from January 1999 to January 2009 was retrieved; With bone turnover, bone metabolism, biochemical markers, bone mineral density, osteoporosis, fractures in Chinese for the search terms, CNKI database from January 1999 to January 2009 was searched. Literatures were limited to English and Chinese languages. Inclusive criteria: the article closely related to predict fracture risk with bone turnover markers and bone mineral density; Exclusive criteria: duplicated documents.
RESULTS AND CONCLUSION: Totally 631 literatures were screened out by computer, according to inclusion and exclusion criteria, 31 documents of which were involved for analysis. Osteoporosis is one of the main causes of elderly disease and death. Early prediction of osteoporotic fracture risk has a great significance. This article describes the bone metabolism, the type of bone biochemical markers, bone mineral density measurement, multi-cell basic unit and the OPG-RANKL-RANK system in bone reconstruction after a long-term fixation; focuses on the use of bone turnover markers and bone mineral density to prognosticate the fracture risk in osteoporosis or after long-term fixation by domestic and foreign academician, and theoretically analyze the feasibility of predicting postoperative fracture healing.

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