中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (34): 9081-9087.doi: 10.12307/2026.852

• 组织工程相关大数据分析 Big data analysis in tissue engineering • 上一篇    下一篇

儿童脑性瘫痪中药用药规律：基于病历与文献的分析

邹玉雄1，2，刘  英1，刘晓蒙2，顾  楠2，朱  玥2，朱晋台2，李书明2，敖梅英2，刘  潜1，2，何  媛1   

  1. 1江西中医药大学附属医院，江西省南昌市  330000；2江西中医药大学中医学院中西医结合一级学科，中西医结合儿童健康研究院，江西省血管瘤中医药防治重点实验室，江西省南昌市  330004
  • 收稿日期:2025-10-15 修回日期:2026-01-19 出版日期:2026-12-08 发布日期:2026-04-15
  • 通讯作者: 何媛，硕士，主治中医师，江西中医药大学附属医院，江西省南昌市 330000 通讯作者：敖梅英，博士，教授，江西中医药大学中医学院中西医结合一级学科，中西医结合儿童健康研究院，江西省血管瘤中医药防治重点实验室，江西省南昌市 330004 通讯作者：刘潜，博士生导师，教授，江西中医药大学附属医院，江西省南昌市 330000；江西中医药大学中医学院中西医结合一级学科，中西医结合儿童健康研究院，江西省血管瘤中医药防治重点实验室，江西省南昌市 330004
  • 作者简介:邹玉雄，男，1998年生，硕士，中医师，主要从事中西医结合基础研究。
  • 基金资助:
    国家自然科学基金项目(82060658)，项目负责人：敖梅英；全国重点实验室自主部署重点研发计划项目(20243BCC31008)，项目负责人：刘潜；江西中医药大学科研培育项目(2023ZDPY001)，项目负责人：刘潜；中西医结合防治儿童疾病及健康保障创新研究团队(CXTD22014)，项目负责人：刘潜；江西中医药大学校级教改项目(2022jzyx-2)，项目负责人：敖梅英

Medication patterns for traditional Chinese medicine in children with cerebral palsy: an analysis based on medical records and literature

Zou Yuxiong1, 2, Liu Ying1, Liu Xiaomeng2, Gu Nan2, Zhu Yue2, Zhu Jintai2, Li Shuming2, Ao Meiying2, Liu Qian1, 2, He Yuan1   

  1. 1Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330000, Jiangxi Province, China; 2Discipline of Chinese and Western Integrative Medicine, Integrated Chinese and Western Medicine Institute for Children Health & Drug Innovation, Key Laboratory of Traditional Chinese Medicine Prevention and Treatment of Hemangioma of Jiangxi Provincial Administration of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, Jiangxi Province, China
  • Received:2025-10-15 Revised:2026-01-19 Online:2026-12-08 Published:2026-04-15
  • Contact: He Yuan, MS, Attending physician, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330000, Jiangxi Province, China Co-corresponding author: Ao Meiying, PhD, Professor, Discipline of Chinese and Western Integrative Medicine, Integrated Chinese and Western Medicine Institute for Children Health & Drug Innovation, Key Laboratory of Traditional Chinese Medicine Prevention and Treatment of Hemangioma of Jiangxi Provincial Administration of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, Jiangxi Province, China Co-corresponding author: Liu Qian, Doctoral supervisor, Professor, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330000, Jiangxi Province, China; Discipline of Chinese and Western Integrative Medicine, Integrated Chinese and Western Medicine Institute for Children Health & Drug Innovation, Key Laboratory of Traditional Chinese Medicine Prevention and Treatment of Hemangioma of Jiangxi Provincial Administration of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, Jiangxi Province, China
  • About author:Zou Yuxiong, MS, Physician, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330000, Jiangxi Province, China; Discipline of Chinese and Western Integrative Medicine, Integrated Chinese and Western Medicine Institute for Children Health & Drug Innovation, Key Laboratory of Traditional Chinese Medicine Prevention and Treatment of Hemangioma of Jiangxi Provincial Administration of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, Jiangxi Province, China
  • Supported by:
    National Natural Science Foundation of China, No. 82060658 (to AMY); Key Research and Development Program of National Key Laboratories, No. 20243BCC31008 (to LQ); Jiangxi University of Chinese Medicine Scientific Research Cultivation Project, No. 2023ZDPY001 (to LQ); Innovative Research Team on Integrated Chinese and Western Medicine for Prevention and Treatment of Pediatric Diseases and Health Protection, No. CXTD22014 (to LQ); University-Level Teaching Reform Project of Jiangxi University of Chinese Medicine, No. 2022jzyx-2 (to AMY)

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摘要：



文题释义：
儿童脑瘫：是一种非进行性的神经系统疾病，主要表现为运动功能障碍和姿势异常。儿童脑瘫一般是大脑在发育过程中受到损伤或发育异常引起的，通常发生在出生前、出生时或出生后的早期阶段。脑瘫的预后因病情严重程度和干预时机而异。早期诊断和干预可以显著改善患儿的功能和生活质量。
Apriori规则分析：是一种用于挖掘数据中频繁项集与关联规则的经典算法，核心思想基于“频繁项集的所有子集也必须是频繁的”这一先验(Apriori)原理。该算法通过逐层搜索(如先找频繁1-项集，再组合生成候选2-项集)并利用支持度(项集出现频率)和置信度(规则可靠程度)2个阈值，筛选出如“X→Y”形式的强关联规则。

背景：江西中医药大学附属医院使用中药治疗儿童脑性瘫痪(简称脑瘫)已有20多年经验，但尚无用药规律分析。
目的：基于病历与文献分析儿童脑瘫证候分型，探讨儿童脑瘫的中药治疗措施与用药规律。
方法：采用循证检索策略对中药治疗儿童脑瘫的文献及病历进行检索和管理；应用文献计量法对数据各特征进行挖掘与分析；通过VOSviewer软件制作可视化知识图谱；使用IBM SPSS Modeler软件进行中药关联规则分析；运用雷达图法对药物四气五味进行分析。
结果与结论：①共纳入503份病历与90篇文献；②证候分析显示：儿童脑瘫所表现中医证型主要为肝肾不足证；③干预措施分析显示：以外治法使用频率最高，内服药物治疗中则以补益肝肾类中药最为常见；④用药规律分析显示：在病历与文献使用频次前20味药物中有12味(60%)相同；山药与茯苓、熟地与茯苓2个药对的支持度皆较高，且置信度高于82.50%，这2个药对具有显著关联性；治疗儿童脑瘫的所有中药中，性以温为主，平、寒次之；味以甘为主，苦、辛次之；归经以肝、肾经为主，脾、心、肺经次之；这些中药组方中基本为无毒药物。结果表明：儿童脑瘫主要表现为肝肾不足，中医临床实践及相关临床研究所使用的方剂多为补益肝肾类，其中六味地黄丸及其衍生方的出现频次最高，配伍以熟地与茯苓、山药与茯苓2个药对使用频率与可靠程度最高，药材性味以温、甘、归肝肾经为主。

https://orcid.org/0009-0007-5340-8842(邹玉雄)；https://orcid.org/0009-0009-6950-6329(何媛)；
https://orcid.org/0000-0001-7633-9172(刘潜)；https://orcid.org/0000-0003-4502-1772(敖梅英)


中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 儿童脑瘫, 中药, 用药规律, 病历回顾性研究, 文献研究 , Apriori规则, 聚类分析, 四气五味

Abstract: BACKGROUND: Jiangxi University of Chinese Medicine Affiliated Hospital has over 20 years of experience in treating cerebral palsy in children with traditional Chinese medicine (TCM). To date, no systematic analysis of TCM medication patterns has been conducted.
OBJECTIVE: To analyze the TCM syndrome types of children with cerebral palsy based on medical records and literature, and to explore TCM treatment approaches and medication patterns for children with cerebral palsy.
METHODS: Evidence-based search strategies were employed to retrieve and manage relevant literature and medical records of TCM treatment for children with cerebral palsy. Bibliometric techniques were utilized to mine and analyze various data features. VOSviewer software was utilized to generate visual knowledge maps. Association rule analysis of TCM was conducted using IBM SPSS Modeler software. Radar diagrams were applied to analyze the four natures and five flavors of Chinese materia medica.
RESULTS AND CONCLUSION: (1) A total of 503 medical records and 90 articles were included in the study. (2) The analysis of TCM syndrome types revealed that the primary feature among children with cerebral palsy was a deficiency in the liver and kidney. (3) Analysis of intervention measures demonstrated that external treatments were the most frequently employed in medical records and the literature. In contrast, internal drug treatments, specifically those drugs that nourish the liver and kidneys, were most prevalent. (4) The analysis of medication rules indicated that among the top 20 medicines utilized in medical records and literature, the duplication rate for high-frequency medicines (n=12) was 60%. Additionally, the support degree levels for the two pairs of Dioscorea opposita Thunb. and Poria cocos (Schw.) Wolf, and Rehmanniae Radix Praeparata and Poria cocos(Schw.) Wolf exceeded 82.50%, suggesting a significant correlation between these two pairs of herbs. The majority of Chinese medicines prescribed for children with cerebral palsy exhibited warm properties, followed by flat and cold; they were primarily sweet, followed by bitter and spicy; the liver and kidney meridians were the most significant meridians, followed by spleen, heart, and lung meridians; and all of them were basically non-toxic. These findings indicate that children with cerebral palsy mainly exhibit liver and kidney deficiency. Most of the prescriptions used in TCM clinical practice and related clinical studies in TCM are aimed at tonifying the liver and kidneys. Among these, Liuwei Dihuang Pills and its derivatives are the most frequently prescribed. Notably, the combinations of Rehmanniae Radix Praeparata with Faria cocos(Schw.) Wolf and Dioscorea opposita Thunb. with Faria cocos(Schw.) Wolf are the most commonly used and reliable pairs. The herbs primarily exhibit warm and sweet properties and target the liver and kidney meridians.


Key words: children with cerebral palsy, traditional Chinese medicine, medication pattern, retrospective study of medical records, literature study, Apriori rules, cluster analysis, four natures and five flavors

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