中国组织工程研究 ›› 2024, Vol. 28 ›› Issue (23): 3759-3765.doi: 10.12307/2024.384
• 组织构建综述 tissue construction review • 上一篇 下一篇
亓雨晴,刘晓然
收稿日期:
2023-05-25
接受日期:
2023-07-07
出版日期:
2024-08-18
发布日期:
2023-09-14
通讯作者:
刘晓然,博士,副教授,首都体育学院运动科学与健康学院,北京市 100191
作者简介:
亓雨晴,女,1999年生,山东省人,汉族,首都体育学院在读硕士,主要从事领域为健康促进与运动能力方面的研究。
基金资助:
Qi Yuqing, Liu Xiaoran
Received:
2023-05-25
Accepted:
2023-07-07
Online:
2024-08-18
Published:
2023-09-14
Contact:
Liu Xiaoran, PhD, Associate professor, School of Kinesiology and Health, Capital University of Physical Education and Sports, Beijing 100191, China
About author:
Qi Yuqing, Master candidate, School of Kinesiology and Health, Capital University of Physical Education and Sports, Beijing 100191, China
Supported by:
摘要:
文题释义:
端粒:是位于真核生物染色体末端的DNA-蛋白质复合物,端粒长度和完整性的维持对于染色体结构和功能正常有着重要意义。
背景:随着年龄增长,人体各系统功能逐渐下降,位于染色体末端的端粒随之缩短,导致多种慢性年龄性疾病的发生与发展。作为一种低经济高效益的干预手段,科学运动已被证明可降低端粒磨损速率、维持端粒长度,延缓人体衰老进程与降低疾病发生概率。同时,较好的健康水平对于实现健康老龄化有着重要意义。
目的:通过分析端粒与身体素质、整理促进端粒长度缩短与慢性疾病发生的共同不利因素以及端粒长度对心血管疾病、癌症、糖尿病、肥胖及心理疾病等常见慢性病发生与发展的影响调控,梳理端粒在健康促进中的作用。总结运动调控端粒长度的可能调节机制,在此可能调节机制的基础上,以健康促进为目的,探讨端粒在运动调控上述相关慢性疾病中的作用。结果与结论:①在身体素质与健康促进方面,人体最大有氧运动能力与肌肉力量的强弱与端粒长度有较强的相关性,长期坚持体育运动可增强身体素质水平以对端粒长度起到维持作用,从而促进人体健康。②在慢性疾病与健康促进方面,端粒长度的异常可促进心血管疾病、癌症、糖尿病、肥胖和心理疾病等部分慢性病的发生,而氧化应激、炎症和端粒酶活性等加速端粒长度的缩短因素亦对上述疾病的发展具有不利影响。③运动对端粒长度的调控具有降低氧化应激与炎症水平、提高端粒酶活性、增强端粒蛋白复合体稳定性的作用,而运动可通过这些调节机制来延缓端粒磨损速率、保持端粒长度一致,从而降低与端粒长度异常有关的心血管疾病、癌症、糖尿病、肥胖及心理疾病等部分慢性病的发病风险;因此,端粒在运动调控相关疾病、促进人体健康方面具有积极作用。
https://orcid.org/0009-0000-6092-3892(亓雨晴)
中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程
中图分类号:
亓雨晴, 刘晓然. 运动调控端粒长度机制与健康促进[J]. 中国组织工程研究, 2024, 28(23): 3759-3765.
Qi Yuqing, Liu Xiaoran. Mechanisms of exercise-regulated telomere length and health promotion[J]. Chinese Journal of Tissue Engineering Research, 2024, 28(23): 3759-3765.
[1] 许志刚,刘晓蕾,董碧蓉,等.衰老的意义、特征及相关生物标记与评估模式[J].中国临床保健杂志,2022,25(4):472-476. [2] WHITTEMORE K, VERA E, MARTíNEZ-NEVADO E, et al. Telomere shortening rate predicts species life span. Proc Natl Acad Sci U S A. 2019;116(30):15122-15127. [3] LANSDORP PM. Telomeres, aging, and cancer: the big picture. Blood. 2022;139(6): 813-821. [4] LAROCCA TJ, SEALS DR, PIERCE GL. Leukocyte telomere length is preserved with aging in endurance exercise-trained adults and related to maximal aerobic capacity. Mech Ageing Dev. 2010;131(2):165-167. [5] LOPRINZI PD, LOENNEKE JP. Lower extremity muscular strength and leukocyte telomere length: implications of muscular strength in attenuating age-related chronic disease. J Phys Act Health. 2016;13(4):454-457. [6] 黄宏兴,吴青,李跃华,等.肌肉、骨骼与骨质疏松专家共识[J].中国骨质疏松杂志,2016,22(10):1221-1229+1236. [7] 董云峰,邱俊强.运动抗衰老:端粒机制的研究进展[J].中国体育科技,2021, 57(2):49-57. [8] MCCLINTOCK B. The behavior in successive nuclear divisions of a chromosome broken at meiosis. Proc Natl Acad Sci U S A. 1939;25(8):405-416. [9] HAYFLICK L, MOORHEAD PS. The serial cultivation of human diploid cell strains. Exp Cell Res. 1961;25:585-621. [10] WATSON JD. Origin of concatemeric T7 DNA. Nat New Biol. 1972;239(94):197-201. [11] GREIDER CW, BLACKBURN EH. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell. 1985;43(2 Pt 1):405-413. [12] MOYZIS RK, BUCKINGHAM JM, CRAM LS, et al. A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci U S A. 1988;85(18):6622-6626. [13] FENG J, FUNK WD, WANG SS, et al. The RNA component of human telomerase. Science. 1995;269(5228):1236-1241. [14] NAKAMURA TM, MORIN GB, CHAPMAN KB, et al. Telomerase catalytic subunit homologs from fission yeast and human. Science. 1997;277(5328):955-959. [15] GRIFFITH JD, COMEAU L, ROSENFIELD S, et al. Mammalian telomeres end in a large duplex loop. Cell. 1999;97(4):503-514. [16] CHERKAS LF, HUNKIN JL, KATO BS, et al. The association between physical activity in leisure time and leukocyte telomere length. Arch Intern Med. 2008;168(2): 154-158. [17] PUTERMAN E, LIN J, BLACKBURN E, et al. The power of exercise: buffering the effect of chronic stress on telomere length. PLoS One. 2010;5(5):e10837. [18] 王福龙,王甄真,陈雁.衰老的分子机制与干预研究的最新进展[J].中国细胞生物学学报,2012,34(8):739-748. [19] ZHU H, BELCHER M, VAN DER HARST P. Healthy aging and disease: role for telomere biology? Clin Sci (Lond). 2011;120(10):427-440. [20] VERMA AK, SINGH P, AL-SAEED FA, et al. Unravelling the role of telomere shortening with ageing and their potential association with diabetes, cancer, and related lifestyle factors. Tissue Cell. 2022;79:101925. [21] KUMAR DEV P, GRAY AJ, SCOTT-HAMILTON J, et al. Co-expression analysis identifies networks of miRNAs implicated in biological ageing and modulated by short-term interval training. Mech Ageing Dev. 2021;199:111552. [22] RUIS P, BOULTON SJ. The end protection problem-an unexpected twist in the tail. Genes Dev. 2021;35(1-2):1-21. [23] GIARDINI MA, SEGATTO M, DA SILVA MS, et al. Telomere and telomerase biology. Prog Mol Biol Transl Sci. 2014;125:1-40. [24] CICCONI A, CHANG S. Shelterin and the replisome: at the intersection of telomere repair and replication. Curr Opin Genet Dev. 2020;60:77-84. [25] NANDAKUMAR J, BELL CF, WEIDENFELD I, et al. The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity. Nature. 2012; 492(7428):285-289. [26] MYLER LR, KINZIG CG, SASI NK, et al. The evolution of metazoan shelterin. Genes Dev. 2021;35(23-24):1625-1641. [27] 刘若江,张翔,连庆元.心肺适能运动处方运动强度确定方法研究述评[J].体育科技文献通报,2023,35(2):248-252. [28] ROSS R, BLAIR SN, ARENA R, et al. Importance of assessing cardiorespiratory fitness in clinical practice: a case for fitness as a clinical vital sign: a scientific statement from the american heart association. Circulation. 2016;134(24): e653-e699. [29] KRAUSS J, FARZANEH-FAR R, PUTERMAN E, et al. Physical fitness and telomere length in patients with coronary heart disease: findings from the Heart and Soul Study. PLoS One. 2011;6(11):e26983. [30] ØSTHUS IB, SGURA A, BERARDINELLI F, et al. Telomere length and long-term endurance exercise: does exercise training affect biological age? A pilot study. PLoS One. 2012;7(12):e52769. [31] MATHUR S, ARDESTANI A, PARKER B, et al. Telomere length and cardiorespiratory fitness in marathon runners. J Investig Med. 2013;61(3):613-615. [32] LOPRINZI PD. Cardiorespiratory capacity and leukocyte telomere length among adults in the united states. Am J Epidemiol. 2015;182(3):198-201. [33] DENHAM J, O’BRIEN BJ, PRESTES PR, et al. Increased expression of telomere-regulating genes in endurance athletes with long leukocyte telomeres. J Appl Physiol (1985). 2016;120(2):148-158. [34] WILLIAMS DM, BUXTON JL, KANTOMAA MT, et al. Associations of leukocyte telomere length with aerobic and muscular fitness in young adults. Am J Epidemiol. 2017;185(7):529-537. [35] COLON M, HODGSON A, DONLON E, et al. Effects of competitive triathlon training on telomere length. J Aging Phys Act. 2019;27(4):510-514. [36] NGUYEN MT, SAFFERY R, BURGNER D, et al. Telomere length and lung function in a population-based cohort of children and mid-life adults. Pediatr Pulmonol. 2019;54(12):2044-2052. [37] HIAM D, SMITH C, VOISIN S, et al. Aerobic capacity and telomere length in human skeletal muscle and leukocytes across the lifespan. Aging (Albany NY). 2020;12(1):359-369. [38] NONSA-ARD R, ANEKNAN P, TONG-UN T, et al. Telomere length is correlated with resting metabolic rate and aerobic capacity in women: a cross-sectional study. Int J Mol Sci. 2022;23(21):13336. [39] 杨玲,黄森.端粒与端粒酶:运动延缓衰老的端粒机制[J].中国组织工程研究,2022,26(35):5733-5740. [40] SONG S, LEE E, KIM H. Does exercise affect telomere length? a systematic review and meta-analysis of randomized controlled trials. Medicina (Kaunas). 2022;58(2):242. [41] 杨裴.不同运动方式对人体DNA损伤、DNA甲基化和端粒长度的影响[J].中国组织工程研究,2024,28(1):147-152. [42] LEE JY, BANG HW, KO JH, et al. Leukocyte telomere length is independently associated with gait speed in elderly women. Maturitas. 2013;75(2):165-169. [43] BAYLIS D, NTANI G, EDWARDS MH, et al. Inflammation, telomere length, and grip strength: a 10-year longitudinal study. Calcif Tissue Int. 2014;95(1):54-63. [44] WOO J, YU R, TANG N, et al. Telomere length is associated with decline in grip strength in older persons aged 65 years and over. Age (Dordr). 2014;36(5):9711. [45] SOARES-MIRANDA L, IMAMURA F, SISCOVICK D, et al. Physical activity, physical fitness, and leukocyte telomere length: the cardiovascular health study. Med Sci Sports Exerc. 2015;47(12):2525-2534. [46] SILLANPää E, LAAKKONEN EK, VAARA E, et al. Biological clocks and physical functioning in monozygotic female twins. BMC Geriatr. 2018;18(1):83. [47] MONTIEL ROJAS D, NILSSON A, PONSOT E, et al. Short telomere length is related to limitations in physical function in elderly european adults. Front Physiol. 2018; 9:1110. [48] BOUNTZIOUKA V, NELSON CP, CODD V, et al. Association of shorter leucocyte telomere length with risk of frailty. J Cachexia Sarcopenia Muscle. 2022;13(3): 1741-1751. [49] 王光旭.弹力带抗阻训练对老年人肌力、行走能力和生活质量影响的实验研究[D].上海:上海体育学院,2018. [50] 首健,陈佩杰,肖卫华.运动对老年骨骼肌的改善效应及其机制[J].中国康复医学杂志,2020,35(9):1140-1145. [51] CARTEE GD, HEPPLE RT, BAMMAN MM, et al. Exercise promotes healthy aging of skeletal muscle. Cell Metab. 2016;23(6):1034-1047. [52] 陈昱圻,郭昌龙,袁国红,等.衰老个体骨骼肌卫星细胞的研究进展[J].中国老年学杂志,2022,42(17):4354-4360. [53] WANG H, HUANG W Y, ZHAO Y. Efficacy of exercise on muscle function and physical performance in older adults with sarcopenia: an updated systematic review and meta-analysis. Int J Environ Res Public Health. 2022;19(13):8212. [54] CHANG KV, CHEN YC, WU WT, et al. Expression of telomeric repeat-containing rna decreases in sarcopenia and increases after exercise and nutrition intervention. Nutrients. 2020;12(12):3766. [55] WANG L, LU Z, ZHAO J, et al. Selective oxidative stress induces dual damage to telomeres and mitochondria in human T cells. Aging Cell. 2021;20(12):e13513. [56] HEWITT G, JURK D, MARQUES FD, et al. Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence. Nat Commun. 2012;3:708. [57] DEMISSIE S, LEVY D, BENJAMIN EJ, et al. Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell. 2006;5(4):325-330. [58] 张丽欣,王琪,于爽,等.女性关键时期端粒-端粒酶系统的影响因素研究进展[J].中国临床药理学与治疗学,2021,26(11):1328-1334. [59] CHEN D, ZHAO G, FU J, et al. Effects of traditional chinese exercise on oxidative stress in middle-aged and older adults: a network meta-analysis. Int J Environ Res Public Health. 2022;19(14):8276. [60] 于政超.抗阻、有氧运动对衰老小鼠骨骼肌铁死亡及NRF2介导的抗氧化系统的影响[D].上海:华东师范大学,2022. [61] 张淑静,王玥,周雨玫,等.跑步运动对小鼠端粒长度和体内氧化抗氧化的影响[J].世界中医药,2019,14(2):330-335. [62] KHAN S, CHUTURGOON AA, NAIDOO DP. Telomeres and atherosclerosis. Cardiovasc J Afr. 2012;23(10):563-571. [63] SAVALE L, CHAOUAT A, BASTUJI-GARIN S, et al. Shortened telomeres in circulating leukocytes of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2009;179(7):566-571. [64] NIMMO MA, LEGGATE M, VIANA JL, et al. The effect of physical activity on mediators of inflammation. Diabetes Obes Metab. 2013; 15 Suppl 3:51-60. [65] CLUCKEY TG, NIETO NC, RODONI BM, et al. Preliminary evidence that age and sex affect exercise-induced hTERT expression. Exp Gerontol. 2017;96:7-11. [66] 张冬茹.有氧运动对MI后大鼠心肌细胞端粒酶活性及细胞增殖的影响研究[D].扬州:扬州大学,2017. [67] WERNER C, FüRSTER T, WIDMANN T, et al. Physical exercise prevents cellular senescence in circulating leukocytes and in the vessel wall. Circulation. 2009; 120(24):2438-2447. [68] LAYE MJ, SOLOMON TP, KARSTOFT K, et al. Increased shelterin mRNA expression in peripheral blood mononuclear cells and skeletal muscle following an ultra-long-distance running event. J Appl Physiol (1985). 2012;112(5):773-781. [69] INSEL KC, MERKLE CJ, HSIAO CP, et al. Biomarkers for cognitive aging part I: telomere length, blood pressure and cognition among individuals with hypertension. Biol Res Nurs. 2012;14(2):124-132. [70] 张舒媛.老年高血压患者血压控制影响因素探究及衰老相关生物标志物端粒损耗对降压疗效的影响[D].北京:北京协和医学院,2021. [71] 田然,张磊楠,张婷婷,等.外周血白细胞端粒长度与早发冠心病的相关性及其影响因素分析[J].中国循环杂志,2016,31(6):541-545. [72] CODD V, NELSON CP, ALBRECHT E, et al. Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet. 2013;45(4):422-427e4272. [73] RICHARDSON GD, BREAULT D, HORROCKS G, et al. Telomerase expression in the mammalian heart. FASEB J. 2012;26(12):4832-4840. [74] ZHANG Y, GUO Y, ZHOU G, et al. Regulation of telomere length and atherosclerosis by protection of telomeres 1 protein. J Nanosci Nanotechnol. 2019;19(12):7953-7959. [75] SAGRIS M, THEOFILIS P, ANTONOPOULOS AS, et al. Inflammatory Mechanisms in COVID-19 and Atherosclerosis: current pharmaceutical perspectives. Int J Mol Sci. 2021;22(12):6607. [76] 芦建东,苏浩,刘敬祺,等.有氧训练和联合训练对成年人心血管健康改善效果差异的比较:meta分析[J].中国康复医学杂志,2022,37(12):1659-1668. [77] 何荣,张丽,李鹏,等.有氧运动对不同血糖水平男性人群动脉僵硬度的即时影响研究[J]. 中国全科医学,2023,26(24):2997-3004. [78] ZHANG Y, WANG C, JIN Y, et al. Activating the PGC-1α/TERT pathway by catalpol ameliorates atherosclerosis via modulating ROS production, DNA damage, and telomere function: implications on mitochondria and telomere link. Oxid Med Cell Longev. 2018;2018:2876350. [79] POOLEY KA, SANDHU MS, TYRER J, et al. Telomere length in prospective and retrospective cancer case-control studies. Cancer Res. 2010;70(8):3170-3176. [80] 张毅,武雨思,宋睿睿,等.外周血白细胞端粒DNA长度与肺癌的关系[J].陕西师范大学学报(自然科学版),2018,46(4):78-82. [81] SHAY JW, WRIGHT WE. Telomeres and telomerase: three decades of progress. Nat Rev Genet. 2019;20(5):299-309. [82] LONGOBUCCO Y, MASINI A, MARINI S, et al. Exercise and oxidative stress biomarkers among adult with cancer: a systematic review. Oxid Med Cell Longev. 2022;2022:2097318. [83] GAMMON MD, NEUGUT AI, SANTELLA RM, et al. The Long Island Breast Cancer Study Project: description of a multi-institutional collaboration to identify environmental risk factors for breast cancer. Breast Cancer Res Treat. 2002; 74(3):235-254. [84] 以功能障碍为中心的中国癌症患者运动康复专家共识[J].中国康复医学杂志,2023,38(1):1-7. [85] BROWN JC, STURGEON K, SARWER DB, et al. The effects of exercise and diet on oxidative stress and telomere length in breast cancer survivors. Breast Cancer Res Treat. 2023;199(1):109-117. [86] TAMURA Y, TAKUBO K, AIDA J, et al. Telomere attrition and diabetes mellitus. Geriatr Gerontol Int. 2016;16 Suppl 1:66-74. [87] 杨雁,王玉萍,刘喆隆,等.胰岛素抵抗患者外周血白细胞端粒长度检测[J].中国医院药学杂志,2011,31(19):1609-1613. [88] 曹岚,李志强,师咏勇,等.端粒长度与2型糖尿病:孟德尔随机化研究与多基因风险评分分析[J].遗传,2020,42(9):882-888. [89] ADAIKALAKOTESWARI A, BALASUBRAMANYAM M, MOHAN V. Telomere shortening occurs in Asian Indian Type 2 diabetic patients. Diabet Med. 2005; 22(9):1151-1156. [90] ABBATECOLA AM, PAOLISSO G. Is there a relationship between insulin resistance and frailty syndrome? Curr Pharm Des. 2008;14(4):405-410. [91] BUCCI M, HUOVINEN V, GUZZARDI MA, et al. Resistance training improves skeletal muscle insulin sensitivity in elderly offspring of overweight and obese mothers. Diabetologia. 2016;59(1):77-86. [92] DIMAURO I, SGURA A, PITTALUGA M, et al. Regular exercise participation improves genomic stability in diabetic patients: an exploratory study to analyse telomere length and DNA damage. Sci Rep. 2017;7(1):4137. [93] TZANETAKOU IP, KATSILAMBROS NL, BENETOS A, et al. “Is obesity linked to aging?”: adipose tissue and the role of telomeres. Ageing Res Rev. 2012;11(2): 220-229. [94] BUXTON JL, WALTERS RG, VISVIKIS-SIEST S, et al. Childhood obesity is associated with shorter leukocyte telomere length. J Clin Endocrinol Metab. 2011;96(5): 1500-1505. [95] ZGHEIB NK, SLEIMAN F, NASREDDINE L, et al. Short telomere length is associated with aging, central obesity, poor sleep and hypertension in lebanese individuals. Aging Dis. 2018;9(1):77-89. [96] TOUPANCE S, KARAMPATSOU SI, LABAT C, et al. Longitudinal association of telomere dynamics with obesity and metabolic disorders in young children. Nutrients. 2022;14(23):5191. [97] 赵连泽,安友仲.端粒长度与冠心病危险因素的研究进展[J].中国循环杂志, 2018,33(5):507-509. [98] 郭怡洵,关晓印,王博,等.肌少性肥胖的发病机制及潜在治疗靶点研究进展[J].中国临床药理学与治疗学,2023,28(3):341-346. [99] BRANDAO CFC, NONINO CB, DE CARVALHO FG, et al. The effects of short-term combined exercise training on telomere length in obese women: a prospective, interventional study. Sports Med Open. 2020;6(1):5. [100] DANKEL SJ, LOENNEKE JP, LOPRINZI PD. The impact of overweight/obesity duration and physical activity on telomere length: an application of the WATCH paradigm. Obes Res Clin Pract. 2017;11(2):247-252. [101] SHIN YA. How does obesity and physical activity affect aging? Focused on telomere as a biomarker of aging. J Obes Metab Syndr. 2019;28(2):92-104. [102] BARBOSA RV, CHIELLI PDC, SATYKO KG, et al. Short-term aerobic exercise did not change telomere length while it reduced testosterone levels and obesity indexes in PCOS: a randomized controlled clinical trial study. Int J Environ Res Public Health. 2021;18(21):11274. [103] LI P, LIU T, LIU J, et al. Promoter polymorphism in the serotonin transporter (5-HTT) gene is significantly associated with leukocyte telomere length in Han Chinese. PLoS One. 2014;9(4):e94442. [104] HOEN PW, ROSMALEN JG, SCHOEVERS RA, et al. Association between anxiety but not depressive disorders and leukocyte telomere length after 2 years of follow-up in a population-based sample. Psychol Med. 2013;43(4):689-697. [105] RIDOUT KK, RIDOUT SJ, PRICE LH, et al. Depression and telomere length: A meta-analysis. J Affect Disord. 2016;191:237-247. [106] 赵源,马姗姗,束晨晔,等.从端粒和端粒酶探析冥想对压力的缓解作用[J].心理科学,2020,43(4):1010-1016. [107] 王庭慧.大鼠大强度游泳、运动自愿程度和端粒长度的关联性研究[D].北京:北京体育大学,2019. [108] CHEUNG DST, DENG W, TSAO SW, et al. Effect of a qigong intervention on telomerase activity and mental health in chinese women survivors of intimate partner violence: a randomized clinical trial. JAMA Netw Open. 2019; 2(1):e186967. |
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1.1.6 检索策略 PubMed与中国知网数据库检索策略见图1。
1.1.7 检索文献类型 研究原著、综述和荟萃分析。
1.3 文献质量评估和数据的提取 共检索文献413篇,根据纳入与排除标准筛选后,排除不符合要求的文献305篇,最终纳入文献108篇,文献检索筛选流程见图2。
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文题释义:
端粒:是位于真核生物染色体末端的DNA-蛋白质复合物,端粒长度和完整性的维持对于染色体结构和功能正常有着重要意义。文章通过分析端粒与身体素质、整理促进端粒长度缩短与慢性疾病发生的共同不利因素以及端粒长度对心血管疾病、癌症、糖尿病、肥胖及心理疾病等常见慢性病发生与发展的影响调控,梳理端粒在健康促进中的作用。总结运动调控端粒长度的可能调节机制,在此可能调节机制的基础上,以健康促进为目的,探讨端粒在运动调控上述相关慢性疾病中的作用。
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