中国组织工程研究 ›› 2024, Vol. 28 ›› Issue (1): 107-112.doi: 10.12307/2023.769
• 干细胞综述 stem cell review • 上一篇 下一篇
黄勇彬1,王 涛1,娄园一1,庞景群1,陈光华2
收稿日期:
2022-11-15
接受日期:
2023-01-04
出版日期:
2024-01-08
发布日期:
2023-06-28
通讯作者:
陈光华,博士,主任医师,副教授,博士生导师,广东医科大学附属医院骨科中心,广东省湛江市 524000
作者简介:
黄勇彬,男,1997年生,广东医科大学在读硕士,初级医师,主要从事创伤骨科、骨质疏松、肌肉萎缩等方面的研究。
基金资助:
Huang Yongbin1, Wang Tao1, Lou Yuanyi1, Pang Jingqun1, Chen Guanghua2
Received:
2022-11-15
Accepted:
2023-01-04
Online:
2024-01-08
Published:
2023-06-28
Contact:
Chen Guanghua, MD, Chief physician, Associate professor, Doctoral supervisor, Orthopedic Center of Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, Guangdong Province, China
About author:
Huang Yongbin, Master candidate, Junior physician, Guangdong Medical University, Zhanjiang 524000, Guangdong Province, China
Supported by:
摘要:
文题释义:
间充质干细胞:来源于胚胎发育的中胚层,具有多方向分化的潜能,在相关信号或外来因素的刺激下可分化为心肌、成骨、成脂、上皮等细胞。目前,已有大量研究证实间充质干细胞可用于治疗心血管疾病、肾病、糖尿病、肌腱损伤等。肌肉组织修复:肌肉组织结构破坏涉及肌膜的破坏、细胞骨架的损伤以及细胞内基质的异常,而肌肉组织修复包括坏死肌纤维的清除、肌纤维的再生、新生肌肉组织的重塑。
结果与结论:①间充质干细胞促进肌纤维增殖修复的相关机制复杂,多以抗炎、抑制间质纤维化、抑制脂肪形成等方式促进肌纤维增殖修复;②基于间充质干细胞的相关生物支架、细胞共培养等可明显弥补间充质干细胞定植后存活率低的缺点;③当前间充质干细胞疗法仍有明显的局限性,未来间充质干细胞联合其他治疗方式应当成为主要的发展趋势。
https://orcid.org/0000-0002-6860-0489(黄勇彬) ;https://orcid.org/0000-0002-8877-1322(陈光华)
中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
中图分类号:
黄勇彬, 王 涛, 娄园一, 庞景群, 陈光华. 间充质干细胞促进肌肉组织修复的应用前景[J]. 中国组织工程研究, 2024, 28(1): 107-112.
Huang Yongbin, Wang Tao, Lou Yuanyi, Pang Jingqun, Chen Guanghua. Application prospect of mesenchymal stem cells in promoting muscle tissue repair[J]. Chinese Journal of Tissue Engineering Research, 2024, 28(1): 107-112.
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1.1.6 检索策略 以PubMed数据库为例,检索策略见图1。
1.1.7 检索文献量 中文文献43篇,英文文献307篇。
1.3 质量评估和数据提取 通过上述数据库检索,并按入组标准进行人工筛选,纳入相关研究原著、综述、荟萃分析、基础研究、国内外权威学术会议报告共350篇(中国知网31篇、维普5篇、万方7篇、PubMed 297篇、Embase 3篇及Web of Science 7篇),最后筛选所得文献98篇,中文文献5篇(中国知网3篇、维普1篇、万方1篇),英文文献93篇(PubMed 93篇、Embase 0篇及Web of Science 0篇),见图2。筛选所得文献经过5人小组研究讨论提取数据,信息记录侧重于间充质干细胞促进肌纤维增殖修复方面的研究进展。
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文题释义:
间充质干细胞:来源于胚胎发育的中胚层,具有多方向分化的潜能,在相关信号或外来因素的刺激下可分化为心肌、成骨、成脂、上皮等细胞。目前,已有大量研究证实间充质干细胞可用于治疗心血管疾病、肾病、糖尿病、肌腱损伤等。肌肉组织修复:肌肉组织结构破坏涉及肌膜的破坏、细胞骨架的损伤以及细胞内基质的异常,而肌肉组织修复包括坏死肌纤维的清除、肌纤维的再生、新生肌肉组织的重塑。
中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
肌肉干细胞是存在于肌纤维的基底层下,即肌纤维和细胞外间质之间的卫星细胞,骨骼肌损伤后肌纤维再生的来源主要是卫星细胞的分化。根据肌肉干细胞的生理特性,学者们曾着力于肌肉干细胞的提取、纯化和迁移,用于治疗肌营养不良,但是成效较低。相较于间充质干细胞的多方向分化能力,肌肉干细胞的“单能”特性使其分化为肌纤维的效率相对较高,但是在提取及迁移治疗的过程中,其分化进程难以控制,增殖性相对较低,严重限制了肌肉干细胞移植治疗的应用。因此间充质干细胞以其独特的优势逐渐取代了肌肉干细胞的地位,成为干细胞治疗肌肉组织疾病的主要来源。
中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程
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